PurposeAlthough there is a growing body of literature on the benefits of innovation ecosystem participation for keystone/focal firms, there are limited studies on what motivates or impedes other actors’ participation (i.e. suppliers and complementors) in collaborative innovation. Hence, this study aims to address the root causes of collaborative innovation failure and develop a better understanding of the hindering factors for the generation of collaborative innovation performance in ecosystem-based manufacturing.Design/methodology/approachThis study adopted a qualitative research study with 45 managers involving an online survey with open-ended questions followed by an expert focus group with seven managers from a UK-based high value manufacturing ecosystem. Data analysis and coding followed a highly iterative process using a thematic analysis approach.FindingsThis study identified six common barriers to collaborative innovation from the perspective of supplier firms. Particularly, this study found unique impeding factors in relation to revealed and deterring barriers in an ecosystem-based manufacturing context. This paper argues that suppliers and small- and medium-sized enterprises not only require financial support but also need to develop a strategic mindset, confidence, effective partnerships and knowledge about risks and returns to participate in collaborative innovation.Originality/valueThe extant literature identifies the motivations for joining innovation ecosystems and the prominence of value co-creation activity from the perspective of focal firms or orchestrators. However, this study offers insights into the need for an effective value co-appropriation setup amongst the ecosystem actors including suppliers. Importantly, this study proposes that effective value co-appropriation is essential for making collaborative innovation happen in manufacturing ecosystems.