Disturbed Gastrointestinal Contractility in a
Polycystic Ovary Syndrome Rat Model

Wang, Kai-Lee; Hsia, Shih Min; Wang, Paulus S.; Lin, Pyng-Jing

doi:10.1007/s10620-019-06001-x

Cited by 3 publications

(2 citation statements)

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“…However, previous studies have obtained contradictory findings regarding the effect of the various sex hormones on GI motility ( 25 – 27 ). A recent study based on female dihydrotestosterone (DHT)-treated PCOS rats found lower maximal colon muscle contractility in response to acetylcholine stimulation in DHT-treated rats than in untreated rats ( 28 ). This lower maximal muscle contractility was found to be associated with extracellular calcium levels.…”

Section: Discussionmentioning

confidence: 99%

“…This lower maximal muscle contractility was found to be associated with extracellular calcium levels. This effect occurs partly via a reduction of the responsiveness of acetylcholine and through phosphorylation of 20-kDa regulatory myosin light chain (MLC20) ( 28 ). These findings suggest that hyperandrogenism might be involved in bowel dysmotility, resulting in IBS in women with PCOS.…”

Section: Discussionmentioning

confidence: 99%

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Obesity Exacerbates Irritable Bowel Syndrome-Related Sleep and Psychiatric Disorders in Women With Polycystic Ovary Syndrome

Tseng

Chiu

et al. 2021

Front. Endocrinol.

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Background/ObjectivesPolycystic ovary syndrome (PCOS) and irritable bowel syndrome (IBS) share similar clinical and psychosocial features. We aimed to investigate the clinical characteristics of IBS in women with PCOS, and its relationship with obesity, metabolic and hormonal profiles, as well as sleep and psychiatric disorders.Subjects/MethodsThis is a cross-sectional case-control study of 431 untreated women with PCOS and 259 healthy volunteers. All participants were assessed with a comprehensive clinical evaluation and two questionnaires: the Athens Insomnia Scale (AIS) and the Brief Symptom Rating Scale (BSRS-5). IBS was diagnosed using the Rome III criteria. Obesity was defined as a BMI ≥30 kg/m2. Anthropometric measurements, metabolic, hormonal profiles, and psychosocial morbidities were compared.ResultsWomen with PCOS were more likely to have IBS (10.7% vs 5.8%, p=0.029) and obesity (29% vs 4%, p<0.001) than healthy volunteers. Mixed-type IBS (IBS-M) was the most common subtype (74%) among patients with PCOS and IBS. There was a higher prevalence of psychiatric morbidities (total BSRS-5 score ≥10) in women with PCOS than in healthy women (11.4% vs 3.5%, p<0.001). Women with PCOS and IBS were more likely to have sleep difficulties (67.4% vs 30.9%, p<0.001) and psychiatric morbidities (21.7% vs 10.1%, p=0.019) than those without IBS. Anthropometrics, metabolic and hormonal profiles were similar between PCOS women with and without IBS. Among women with PCOS, those with both IBS and obesity had the highest risk of developing sleep difficulties (odds ratio: 5.91; 95% confidence interval: 1.77–19.77) and psychiatric distress (odds ratio: 4.39; 95% confidence interval: 1.26–15.29) than those without.ConclusionWomen with PCOS have increased IBS, obesity, sleep and psychiatric disturbances. The presence of IBS in PCOS women is associated with sleep and psychiatric disorders. The coexistence of obesity and IBS exacerbates sleep difficulties and psychiatric distress. Screening and management of IBS and obesity might be warranted to improve sleep and psychiatric disturbances in women with PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%