Disturbed Hepatic Function during Isoniazid Chemoprophylaxis

Bailey, William C.; Taylor, Sally L.; Dascomb, Harry E.; Greenberg, Harry B.; Ziskind, Morton M.

doi:10.1164/arrd.1973.107.4.523

Cited by 60 publications

(14 citation statements)

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“…These data confirm earlier observations-made mainly in adults-that some patients receiving INH may develop high levels of serum transaminase without overt signs of liver disease (Scharer and Smith, 1969;Bailey et al, 1973;Mitchell et al, 1975). In most previous studies patients were monitored for liver injury by determination of one transaminase.…”

Section: Discussionsupporting

confidence: 88%

“…In most previous studies patients were monitored for liver injury by determination of one transaminase. The incidence of abnormal SGOT values in these studies ranged from 10 to 20% of the patients taking the drug (Byrd et al, 1972;Bailey et al, 1973;Mitchell et al, 1976).…”

Section: Discussionmentioning

confidence: 86%

“…Several studies have shown there is an asymptomatic rise in the level of SGOT in 10-20% of adults given INH (Scharer and Smith, 1969;Bailey et al, 1973;Mitchell et al, 1975), although clinically overt hepatitis appears to be rare in such patients (Martin and Arthaud, 1970;Garibaldi et al, 1972;Moss et al, 1972;Black et al, 1975;Mitchell et al, 1976).…”

mentioning

confidence: 99%

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Isoniazid liver injury during chemoprophylaxis in children.

Spyridis¹,

Sinaniotis²,

Papadea³

et al. 1979

Archives of Disease in Childhood

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SUMMARY The incidence of INH-associated liver injury was evaluated in 239 children aged between 9 and 14 years, who were receiving 300 mg INH/day for tuberculosis prophylaxis. Serum SGOT and SGPT levels were determined before INH administration and at 4-weekly intervals thereafter.Levels of both enzymes were raised during the first 3 months of treatment in 18 (7 5 %) children, while in 23 (9.6%) children either SGOT or SGPT exceeded normal levels (SGOT >40 units, SGPT >30 units). Only 2 (0 8 %) children showed SGOT and SGPT values above 100 units and in them treatment with INH had to be discontinued. In all other children transaminases returned to normal during uninterrupted INH administration. It was noted also that transaminase values in children who did not exhibit a rise above normal, still had significantly higher levels during treatment compared with before. The findings of this study suggest that liver injury in children receiving INH for prophylaxis occurs more often than it had hitherto been believed but that it is usually mild and transient.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 86%

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Isoniazid liver injury during chemoprophylaxis in children.

Spyridis¹,

Sinaniotis²,

Papadea³

et al. 1979

Archives of Disease in Childhood

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“…20 Although some experts in the mid-1970s recommended monitoring liver function tests only in patients who had prodromal symptoms (malaise, anorexia, nausea and vomiting), Byrd et al 21 found that 73% of their patients had marked elevations in liver function tests (AST Ͼ 5 times ULN) despite being asymptomatic. Other earlier reports 22,23 confirm that serious hepatic dysfunction can occur in asymptomatic patients. One report 13 further suggests that INH hepatotoxicity is rarely associated with symptoms.…”

Section: Discussionmentioning

confidence: 58%

Isoniazid Hepatotoxicity Associated With Treatment of Latent Tuberculosis Infection

Fountain

Tolley

Chrisman

et al. 2005

Chest

231

126

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“…Four stages of INH-related hepatic injury were described by Bailey et al [48], three of which represented varying degrees of elevated liver enzymes in asymptomatic persons. Only the fourth and most serious stage includes patients with symptoms of drug-induced he patic injury.…”

Section: Clinical Features Of Inh-induced Hepatic Injurymentioning

confidence: 99%

Isoniazid-Related Hepatitis

Vasudeva¹,

Woods²

1997

Dig Dis

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Conclusive evidence of isoniazid (INH)-related hepatotoxicity ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure resulting in liver transplantation and/or death has been firmly established. Anticipation of the widespread usage of INH in the prevention and treatment of tuberculosis is expected due to the recent increasing incidence of tuberculosis. The aim of this article is to review the current concepts of pathogenesis, histopathology, risk factors and clinical features of INH-related hepatitis, emphasizing the need for vigilance.

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Disturbed Hepatic Function during Isoniazid Chemoprophylaxis

Cited by 60 publications

References 0 publications

Isoniazid liver injury during chemoprophylaxis in children.

Isoniazid liver injury during chemoprophylaxis in children.

Isoniazid Hepatotoxicity Associated With Treatment of Latent Tuberculosis Infection

Isoniazid-Related Hepatitis

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