2011
DOI: 10.1128/cvi.05118-11
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Disturbed Homeostasis and Multiple Signaling Defects in the Peripheral Blood B-Cell Compartment of Patients with Severe Chronic Sarcoidosis

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Cited by 55 publications
(58 citation statements)
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References 65 publications
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“…In fact, some overlap with known loci for psoriasis and inflammatory bowel disease (7-9), findings consistent with the finding of multiple aberrations in adaptive immunity in patients with sarcoidosis (10)(11)(12). Others have previously demonstrated the significance of reduced levels of nuclear factor-kB (NF-kB)/P65 to sarcoidosis disease severity (12), as well as dysregulation within IL-12 and IL-23 pathways within cutaneous sarcoidosis specimens, using microarray analysis (13).…”
supporting
confidence: 60%
“…In fact, some overlap with known loci for psoriasis and inflammatory bowel disease (7-9), findings consistent with the finding of multiple aberrations in adaptive immunity in patients with sarcoidosis (10)(11)(12). Others have previously demonstrated the significance of reduced levels of nuclear factor-kB (NF-kB)/P65 to sarcoidosis disease severity (12), as well as dysregulation within IL-12 and IL-23 pathways within cutaneous sarcoidosis specimens, using microarray analysis (13).…”
supporting
confidence: 60%
“…It is also notable that these same patients showed increased levels of IL-10 producing systemic B cells, as well as regulatory B cells involved in downregulating inflammation. Additionally, high levels of B-cell activating factor (BAFF), a phenotype typically associated with auto-immune diseases, was found in the serum of patients with active chronic sarcoidosis [51,54,55]. Not only is BAFF important for providing survival and maturation signals for B cells, but it has recently been shown to also participate in T-cell costimulation [56].…”
Section: New Discoveries and Potential Treatmentsmentioning
confidence: 99%
“…Lee et al also found decreased expression of the costimulatory receptors CD19, CD20, CD21 and CD4, in addition to elevated expression of the coinhibitory receptors CD22, CD32, CD35, CD85J and CD152 by sarcoidosis systmic B cells compared with control cells. The sarcoidosis patients also exhibited a 65% reduction in the levels of NF-κB in peripheral systemic B cells [55]. …”
Section: New Discoveries and Potential Treatmentsmentioning
confidence: 99%
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“…Despite being a T-cell-mediated disease, some evidence suggests that B-cells may play a role in the pathogenesis of sarcoidosis [32]. Rituximab, a monoclonal antibody targeting B-cells, was recently tested in sarcoidosis [33].…”
Section: Biological Agentsmentioning
confidence: 99%