Disturbed laterality of non-rapid eye movement sleep oscillations in post-stroke human sleep: a pilot study

Simpson, Benjamin K.; Rangwani, Rohit; Abbasi, Aamir; Chung, Jeffrey M.; Reed, Chrystal M.; Gulati, Tanuj

doi:10.3389/fneur.2023.1243575

Cited by 2 publications

(1 citation statement)

References 78 publications

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“…The spindle detection applied here is an algorithm that has been used recently ( Sela et al, 2016 ; Kim et al, 2019 ; Silversmith et al, 2020 ; Simpson et al, 2023 ) and was applied separately to M1 and CB LFPs. Channels without obvious artifacts were first z -scored and averaged to form a virtual LFP channel.…”

Section: Methodsmentioning

confidence: 99%

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Fleischer,

Abbasi,

Gulati

2024

eNeuro

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Sleep spindles appear to play an important role in learning new motor skills. Motor skill learning engages several regions in the brain with two important areas being the motor cortex (M1) and the cerebellum. However, the neurophysiological processes in these areas during sleep, especially how spindle oscillations affect local and cross-region spiking, are not fully understood. We recorded activity from the M1 and cerebellar cortex in 8 rats during spontaneous activity to investigate how sleep spindles in these regions are related to local spiking as well as cross-region spiking. We found that M1 firing was significantly changed during both M1 and cerebellum spindles and this spiking occurred at a preferred phase of the spindle. On average, M1 and cerebellum neurons showed most spiking at the M1 or cerebellum spindle peaks. These neurons also developed a preferential phase-locking to local or cross-area spindles with the greatest phase-locking value at spindle peaks; however, this preferential phase-locking wasn't significant for cerebellar neurons when compared to cerebellum spindles. Additionally, we found the percentage of task-modulated cells in the M1 and cerebellum that fired with non-uniform spike-phase distribution during M1/ cerebellum spindle peaks were greater in the rats that learned a reach-to-grasp motor task robustly. Finally, we found that spindle-band LFP coherence (for M1 and cerebellum LFPs) showed a positive correlation with success rate in the motor task. These findings support the idea that sleep spindles in both the M1 and cerebellum recruit neurons that participate in the awake task to support motor memory consolidation.Significance StatementNeural processing during sleep spindles is linked to memory consolidation. However, little is known about sleep activity in the cerebellum and whether cerebellum spindles can affect spiking activity in local or distant areas. We report the effect of sleep spindles on neuron activity in the M1 and cerebellum—specifically their firing rate and phase-locking to spindle oscillations. Our results indicate that awake practice neuronal activity is tempered during local M1 and cerebellum spindles, and during cross-region spindles, which may support motor skill learning. We describe spiking dynamics in motor networks spindle oscillations that may aid in the learning of skills. Our results support the sleep reactivation hypothesis and suggest that awake M1 activity may be reactivated during cerebellum spindles.

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Section: Methodsmentioning

confidence: 99%

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Fleischer,

Abbasi,

Gulati

2024

eNeuro

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A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer Disease

Mattioni,

Carsetti,

Bruqi

et al. 2024

Preprint

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Selective elimination of early pathological TAU species may be a promising therapeutic strategy to reduce TAU accumulation that contributes to neurodegeneration and hallmarks Alzheimer disease (AD). By performing a genetic analysis of a cohort of 435 patients with AD, we defined the NDP52GEvariant (rs550510) of the autophagic receptor NDP52 (also known as CALCOCO2) as a protective factor for AD. We provide evidence that inin vitrosystems and in aDrosophila melanogastermodel of TAU-induced AD, NDP52 reduces the accumulation of pathological forms of TAU through the autophagic process and rescues typical neurodegenerative phenotypes induced by hTAU-toxicity. More importantly, we showed that the NDP52GEvariant is much more effective in this respect than NDP52WT. Mechanistically, we showed that NDP52 directly binds pathological phospho-TAU, and that NDP52WTand NDP52GEbind them with comparable efficiency. On the contrary, we showed that NDP52GEbinds the autophagic machinery (LC3C and LC3B) more efficiently than NDP52WT. We also showed for the first time that NDP52 is a direct target of protein phosphatase 2A (PP2A)in vitro, opening the way to the possibility that this phosphatase may fine-tune the autophagic function of NDP52 in AD. Finally, we found a positive correlation between the worldwide distribution of the allele encoding NDP52GEand the incidence or prevalence of AD. Overall, our work highlights the variant NDP52GEas a resilience factor in AD that shows a robust effectiveness to drive pathological TAU degradation.

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Disturbed laterality of non-rapid eye movement sleep oscillations in post-stroke human sleep: a pilot study

Cited by 2 publications

References 78 publications

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

Modulation of Neural Spiking in Motor Cortex–Cerebellar Networks during Sleep Spindles

A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer Disease

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