Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism

M, Ito; Takamatsu, Junta; Sasaki, Ichiro; Hiraiwa, Tomoko; Fukao, Akira; Murakami, Yasuhiro; Isotani, Haruhiko; Miyauchi, Akira; Kuma, Kanji; Hanafusa, Toshiaki

doi:10.1016/j.amjmed.2004.04.027

Cited by 32 publications

(17 citation statements)

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“…Our findings of a lower HL activity correspond to what had been previously described in overt hypothyroidism. The reduced enzyme activity, together with other factors, such as the previously reported disturbed metabolism of remnant lipoproteins in sH (25), could account for the triglyceride enrichment of LDL observed in the present study. These changes in LDL conformation may contribute to the atherogenic process.…”

Section: Discussionmentioning

confidence: 44%

“…With regard to sH, Duntas et al (23) also found more oxidized LDL in sH measured by means of monoclonal antibodies. Other qualitative lipid alterations, such as abnormal catabolism of remnant lipoproteins (24,25), have been described in both overt and sH patients, too. However, important aspects of lipoprotein metabolism, such as the degree of hepatic lipase (HL) activity in sH, and its relationship with qualitative lipid alterations have not been established.…”

Section: Introductionmentioning

confidence: 96%

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Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment

Brenta

Berg

Arias

et al. 2007

Thyroid

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Section: Discussionmentioning

confidence: 44%

Section: Introductionmentioning

confidence: 96%

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment

Brenta

Berg

Arias

et al. 2007

Thyroid

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“…The thyroid hormone effects on LDL-C receptor expression and cholesterol absorption outweigh the effects of decreased hepatic cholesterol synthesis by HMG CoA reductase, leading to a net accumulation of serum LDL-C in hypothyroidism. In addition to LDL-C, a disturbed metabolism of TG-rich lipoprotein or non-HDL-C (which includes both LDL-C and TG-rich lipoprotein) occurs in hypothyroidism, and these changes are also observed in mild hypothyroidism (15,16). Thyroid hormone increases lipoprotein lipase activity.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Markers Reflecting Thyroid Function in Athyreotic Patients on Levothyroxine Monotherapy

Miyauchi

Hisakado

et al. 2017

Thyroid

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Background: Some investigators reported that among athyreotic patients on levothyroxine (LT4) monotherapy following total thyroidectomy, the patients with normal serum thyrotropin (TSH) levels had mildly low serum free triiodothyronine (fT3) levels, whereas the patients with mildly suppressed serum TSH levels had normal serum fT3 levels, and the patients with strongly suppressed serum TSH had elevated serum fT3 levels. The objective of the present study was to clarify which of these three patient groups is closer to their preoperative euthyroid condition.Methods: A total of 133 consecutive euthyroid patients with papillary thyroid carcinoma who underwent a total thyroidectomy were prospectively studied. The patients' serum levels of lipoproteins, sex hormone-binding globulin, and bone metabolic markers measured preoperatively were compared with the levels measured at postoperative LT4 therapy 12 months after the thyroidectomy.Results: The postoperative serum sex hormone-binding globulin (p < 0.001) and bone alkaline phosphatase (p < 0.01) levels were significantly increased in the patients with strongly suppressed TSH levels (≤0.03 μIU/mL). The postoperative serum low-density lipoprotein cholesterol levels were significantly increased (p < 0.05), and the serum tartrate-resistant acid phosphatase-5b levels were significantly decreased (p < 0.05) in the patients with normal TSH (0.3 < TSH ≤5 μIU/mL). In the patients with mildly suppressed TSH (0.03 < TSH ≤0.3 μIU/mL) and fT3 levels equivalent to their preoperative levels, all metabolic markers remained equivalent to their preoperative levels.Conclusions: The serum biochemical markers of thyroid function in patients on LT4 following total thyroidectomy suggest that the patients with mildly suppressed TSH levels were closest to euthyroid, whereas those with normal TSH levels were mildly hypothyroid and those with strongly suppressed TSH levels were mildly hyperthyroid. These data may provide novel information on the management of patients following total thyroidectomy for thyroid cancer or benign thyroid disease.

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“…With regard to the TG-rich lipoprotein in hypothyroidism, we previously reported the disturbed metabolism of remnant lipoprotein in overt hypothyroidism (OH) [12] and subclinical hypothyroidism (SH) [13].…”

Section: Resultsmentioning

confidence: 99%

Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

Kitanaka

Arishima

et al. 2013

Endocr J

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Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism

Cited by 32 publications

References 22 publications

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment

Biochemical Markers Reflecting Thyroid Function in Athyreotic Patients on Levothyroxine Monotherapy

Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

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Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism

Cited by 32 publications

References 22 publications

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T4Treatment

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T4Treatment

Biochemical Markers Reflecting Thyroid Function in Athyreotic Patients on Levothyroxine Monotherapy

Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients

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Product

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Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment

Lipoprotein Alterations, Hepatic Lipase Activity, and Insulin Sensitivity in Subclinical Hypothyroidism: Response to L-T₄Treatment