Disturbed Urinary Excretion Pattern of Oestrogens in Newborns With Congenital Dislocation of the Hip

Andrén, Lars; Ne, Borglin

doi:10.1530/acta.0.0370427

Cited by 14 publications

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“…In the dog it has been possible to increase the occurrence of hip dysplasia by giving relaxin to newborn pups, and to produce hip dysplasia in the Greyhound [l 1,27,32,36]. 'It does not prove, however, that estrogens have anything to do with etiology and pathogenesis of spontaneously occurring hip dysplasia' [12].…”

Section: Chemical and Hormonal Influencesmentioning

confidence: 99%

Observations and Research on Hip Dysplasia

1975

Vet Pathol

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Hip dysplasia affects man and all other domestic mammals. In man, 1.3 children in 1000 are affected. In dogs the prevalence may run over 50% in large dogs if control measures have not been practiced. Few data are available on the prevalence of hip dysplasia in other mammals, but it is thought to be low. The disease is undoubtedly rare in undomesticated animals. No specific genetic pattern of inheritance has been demonstrated in this variable disease. It has been demonstrated that both genetic and environmental influences contribute to development, regardless of the species affected [5, 9, 20, 21, 26, 47, 50]. Consequently, the disease has been designated as polygenic or multigenic. There is no evidence that a primary defect of bone exists but rather the disease is a failure of the muscles and other soft tissues to hold the hip joint in full congruity [20, 21]. This is further supported by the fact that bony dysplasia can be increased, decreased, or prevented by controlling the degree of joint instability and incongruity [35]. No other malformations are associated with the disease [52], which signifies that hip dysplasia is ‘many diseases that end up with common degenerative lesions of the hip joint’ [51]. Inborn metabolic errors of chemical and hormonal origin are not evident [34, 58]. The quantity of hormones needed to produce hip dysplasia experimentally far exceeded those that could be produced by any biological system [34, 36, 57]. A causal relationship between muscles and soft tissue defects or pathological changes other than lack of muscle mass or strength has not been established [25, 26]. Experimentally, hip dysplasia may be produced in many ways [27, 36, 47, 50, 58, 59]. These include any circumstances that contribute to an unstable hip joint, that is, adductor forces, lack of muscle strength, chemical relaxation of the pelvic soft tissues, traumatic injury to the hip joint, and overloading of the joint by weight. Hip dysplasia is a concentration of factors from a pool of genetic weaknesses and environmental stresses that fall into a programmed pattern of progressive remodelling and degenerative joint disease.

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Section: Chemical and Hormonal Influencesmentioning

confidence: 99%

Observations and Research on Hip Dysplasia

1975

Vet Pathol

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“…The postulated delayed neurological maturation plus the delayed ossification of the cartilage above the acetabular rim revealed as a fact by an abnormal acetabular index, plus increased chondral viscoelasticity, could each arise as variations around the mean of a normal developmental pattern. That means an agent or agents in the maternal circulation might cross the placental barrier sometime during the last trimester of pregnancy to cause those changes, and not necessarily during its final week or two (2,6,14,25,27,30). If so biochemical studies of the infant's blood or serum after a CDH became apparent would not likely show evidence of them.…”

mentioning

confidence: 99%

Pathogenesis of Congenital Hip Dysplasia (CDH). A Proposal

Frost¹

1989

Vet Comp Orthop Traumatol

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“…Ο ακτινολογικός έλεγχος τής ομάδος αυτής έδειξεν τήν ϋπαρξιν του κοτυλιαίου έντυπώματος, εις εννέα δεξιά ισχία, τά 1, 2, 3, 4, 5, 8, 18, 19, 27 καί εις δέκα αριστερά τά 1, 2,3,4,5,8,11,19,22,27, ήτοι εις δέκα εννέα ισχία έκ τοϋ συνόλου των 76 τής ομάδος αυτής. Εις τά υπόλοιπα 57 δέν υφίσταται τό έντύπωμα εις ούδεμίαν θέσιν.…”

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Η Σημασια Του Κοτυλιαιου Εντυπωματος Εις Την Πρωιμον Διαγνωσιν Του Συγγενους Εξαρθρηματος Του Ισχιου

Κανακησ¹

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Μέση σ τ ι β ά ς: 'Αποτελείται από ένα μόνον μΟν, τόν μέσον γλουτιαΐον. Ή μεγίστη σημασία αύτοΟ έγκειται εις τό ότι συμβάλλει εις τήν συγκράτησιν της θέσεως καί τής ισορροπίας του σώματος, ιδίως, κατά τήν βάδισιν καί τόν δρόμον. Τό έργον του μέσου γλουτιαίου παύει νά έκπληροΟται έπϊ διαυχενικοϋ κατάγματος, ραιβοΟ ισχίου καί ΣΕΙ, ότε παράγεται τό χαρακτηριστικόν σημεΐον Trendelenburg.Έν τ ώ βάθει στιβάς: Αΰτη αποτελείται από τους έξης μΰας: 1) μικρού γλουτιαίου, 2) πυραμοειδοΟς ή άπιοειδοΟς, 3) έσω θυροειδοΟς, 4) των διδύμων, 5) τοΟ τετραγώνου μηριαίου, 6).τοϋ έξω θυροειδοΟς. "Απαντες πλην τοΰ μικρού γλουτιαίου αποτελούν τους έξω στροφείς τοΰ μηρού μϋας."Εσω Μύες τής Πυέλου: Ούτοι είναι δύο, ό λαγονοψοΤτης καί έλάσσων ψοίτης. 4) Μύες του μηρού:Οϊ μύες τοΰ μηροΰ αναλόγως τής θέσεως αυτών διαιρούνται εις: α) προσθίους, β) έσω, γ) οπίσθιους μηριαίους. Οϊ μύες ούτοι περιβάλλονται ύπό κοινής περιτονίας, τής μηριαίας, ήτις χωρίζει τούτους άπ' αλλήλων διά μεσομυίων διαφραγμάτων. Α) Πρόσθιοι μύες είναι τρεις: 1 ) ό τείνων τήν πλατεΐαν περιτονίαν, 2) ό ραπτικός, 3) ό τετρακέφαλος μηριαίος. Β) "Εσω μύες ή προσαγωγοί τοΰ μηροΰ: Ούτοι είναι πέντε, καταλαμβάνουν δέ τό έσω μέρος τοΰ μηρού, όπου παρεμ βάλλονται δίκην σφηνός μεταξύ των προσθίων καί οπισθίων μηριαίων. Διατάσσονται εις τρεις στιβάδας, τήν έπιπολής, τήν μέσην καί τήν έν τ<5 βάθει. Ή πρώτη περιλαμβάνει: 1) τόν κτενίτην, 2) τόν μακρόν προσαγωγόν καί 3) τόν ίσχνόν προσαγωγόν. Ή δευτέρα τόν βραχύ προσαγωγόν, ή δέ έν τώ βάθει τόν μέγα προσαγωγόν μΰν. Γ) "Οπίσθιοι μηριαίοι μΰες: (καμπτήρες). Ούτοι είναι τρείς: 1) ό δικέφαλος μηριαίος, 2) ό ήμιτενοντώδης, 3) ήμιυμενώδης.

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Disturbed Urinary Excretion Pattern of Oestrogens in Newborns With Congenital Dislocation of the Hip

Cited by 14 publications

References 0 publications

Observations and Research on Hip Dysplasia

Observations and Research on Hip Dysplasia

Pathogenesis of Congenital Hip Dysplasia (CDH). A Proposal

Η Σημασια Του Κοτυλιαιου Εντυπωματος Εις Την Πρωιμον Διαγνωσιν Του Συγγενους Εξαρθρηματος Του Ισχιου

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