Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics

Xu, Xueli; Xu, Shanbin; Wan, Jipeng; Wang, Diqing; Pang, Xinlong; Gao, Yuan; Ni, Nengyi; Chen, Fan; Sun, Xiao

doi:10.1016/j.bioactmat.2023.06.016

Cited by 12 publications

(6 citation statements)

References 165 publications

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“…Biomaterials for NP tissue regeneration have focused mainly on injectable synthetic or biologically based hydrogels, including non-degradable polyethylene glycol, polylactic acid-glycolic acid or poly(hydroxyethyl methacrylate), biodegradable hyaluronic acid, collagen, chitosan, gelatin, alginate, and so on [ 46 , 47 ]. Decellularized tissue-specific ECM (dECM) materials have received considerable attention in recent years due to their high biocompatibility, excellent tissue integration, and intrinsic bio-inductive factors that can induce tissue-specific cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration

Zhang,

Du,

et al. 2024

Biomater Res

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Intervertebral discs (IVDs) have a limited self-regenerative capacity and current strategies for IVD regeneration are unsatisfactory. Recent studies showed that small extracellular vesicles derived from M2 macrophage cells (M2-sEVs) inhibited inflammation by delivery of various bioactive molecules to recipient cells, which indicated that M2-sEVs may offer a therapeutic strategy for the repair of IVDs. Herein, we investigated the roles and mechanisms of M2-sEVs on IVD regeneration. The in vitro results demonstrated that M2-sEVs inhibited pyroptosis, preserved cellular viability, and promoted migration of nucleus pulposus cells (NPCs). Bioinformatics analysis and verification experiments of microRNA (miR) expression showed that miR-221-3p was highly expressed in M2-sEVs. The mechanism of action was explored and indicated that M2-sEVs inhibited pyroptosis of NPCs through transfer of miR-221-3p, which suppressed the expression levels of phosphatase and tensin homolog and NOD-, LRR-, and pyrin domain-containing protein 3. Moreover, we fabricated decellularized ECM-hydrogel (dECM) for sustained release of M2-sEVs, which exhibited biocompatibility and controlled release properties. The in vivo results revealed that dECM-hydrogel containing M2-sEVs (dECM/M2-sEVs) delayed the degeneration of intervertebral disc degeneration (IDD) models. In addition to demonstrating a promising therapeutic for IDD, this study provided valuable data for furthering the understanding of the roles and mechanisms of M2-sEVs in IVD regeneration.

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Section: Discussionmentioning

confidence: 99%

M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration

Zhang,

Du,

et al. 2024

Biomater Res

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“…The exact mode of QDs on actin depolymerization awaits further exploration. Lately, many nanomaterials have been reported to interact and alter the actin cytoskeleton [71][72][73][74]. In 2022, Park et al reported that graphene flakes, a type of carbon nanomaterial, led to a significant increase in actin filament elongation rates [75].…”

Section: Discussionmentioning

confidence: 99%

“…In the future, it would be interesting to further quantify our actin assembly and disassembly data by looking at the effects of the QDs on actin dynamics using TIRF microscopy and then analyzing the filament lengths to provide more evidence supporting the biphasic mode of the QDs' action on actin dynamics. In addition, Tian et al also reported that the GO nanosheets displayed a high binding affinity to G-actin, which leads to changes in Lately, many nanomaterials have been reported to interact and alter the actin cytoskeleton [71][72][73][74]. In 2022, Park et al reported that graphene flakes, a type of carbon nanomaterial, led to a significant increase in actin filament elongation rates [75].…”

Section: Discussionmentioning

confidence: 99%

CdSe/ZnS Quantum Dots’ Impact on In Vitro Actin Dynamics

Chand,

Le,

Kim

2024

IJMS

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Quantum dots (QDs) are a novel type of nanomaterial that has unique optical and physical characteristics. As such, QDs are highly desired because of their potential to be used in both biomedical and industrial applications. However, the mass adoption of QDs usage has raised concerns among the scientific community regarding QDs’ toxicity. Although many papers have reported the negative impact of QDs on a cellular level, the exact mechanism of the QDs’ toxicity is still unclear. In this investigation, we study the adverse effects of QDs by focusing on one of the most important cellular processes: actin polymerization and depolymerization. Our results showed that QDs act in a biphasic manner where lower concentrations of QDs stimulate the polymerization of actin, while high concentrations of QDs inhibit actin polymerization. Furthermore, we found that QDs can bind to filamentous actin (F-actin) and cause bundling of the filament while also promoting actin depolymerization. Through this study, we found a novel mechanism in which QDs negatively influence cellular processes and exert toxicity.

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“…Due to their own antigenicity and cytotoxicity, some nanomaterials can kill tumor cells with the help of the immune system or directly. 24,25 New therapies based on the special properties of nanomaterials have also emerged, such as photothermal and photodynamic therapies as well as magnetic nanoparticle hyperthermia. 26 Nanomaterials can also act as drug carriers or additives to enhance the effect of tumor treatment, such as liposomal drug delivery, radiotherapy sensitization, radiofrequency ablation (RFA), etc.…”

Section: The Application Of Nanomaterials In Tumor Therapymentioning

confidence: 99%

“…Nanomaterials have good biocompatibility and unique optical, thermodynamic, magnetic, and mechanical properties. , First of all, nanomaterials can be directly applied to tumor therapy as drugs. Due to their own antigenicity and cytotoxicity, some nanomaterials can kill tumor cells with the help of the immune system or directly. , New therapies based on the special properties of nanomaterials have also emerged, such as photothermal and photodynamic therapies as well as magnetic nanoparticle hyperthermia . Nanomaterials can also act as drug carriers or additives to enhance the effect of tumor treatment, such as liposomal drug delivery, radiotherapy sensitization, radiofrequency ablation (RFA), etc. − The role of some nonmetallic nanomaterials in tumor treatment has also been gradually discovered, such as C 60 , carbon nanotubes (CNTs), graphene, chitosan nanoparticles, etc., which shows great potential in the field of tumor therapy .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis

Wang,

Pang,

Dong

et al. 2023

Environ. Health

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Tumor metastasis is one of the most significant biological characteristics of malignant tumors. Advances in nanotechnology provide a new direction for tackling malignant tumors. Unlike previous studies that focused on the use of nanomaterials to eliminate tumors and avoid metastasis, this work focuses on summarizing the mechanisms by which some nanomaterials promote tumor metastasis in some cases. In this Review, we summarized recent research about various nanomaterials promoting tumor metastasis. The mechanisms of nanomaterials in this process have been highlighted, including the induction of epithelial–mesenchymal transition in tumor cells by nanomaterials, the interaction of nanomaterials with the vasculature, and the induction of inflammation by nanomaterials. Elucidating the mechanism of nanomaterials promoting tumor metastasis is beneficial to guide the development and application of safe and efficient nanomaterials, which can effectively reduce the incidence of tumor metastasis in the future.

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Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics

Cited by 12 publications

References 165 publications

M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration

M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration

CdSe/ZnS Quantum Dots’ Impact on In Vitro Actin Dynamics

Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis

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