Distúrbios da hemostasia em crianças portadoras de cardiopatias congênitas

Sena, Tais S.; Filho, Silvio R. Pinheiro; Lyra, Isa Menezes

doi:10.1590/s1516-84842010005000036

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The distortion of cardiac morphology in congenital heart diseases leads to variable hemodynamic consequences that promote myocardial adaptation and may eventually induce ventricular dysfunction. 20 In 1960, Somerville, et al 21 have observed hemostatic changes in 50 patients with congenital heart disease (40 cyanotic and 10 noncyanogenic), including TOF, tricuspid atresia, pulmonary stenosis, bypass atrial septum, and transposition of the great arteries. Disorders that they identified were hypofibrinogenemia, thrombocytopenia, and the reduction of thromboplastin synthesis.…”

Section: Discussionmentioning

confidence: 99%

Concordance of Congenital Heart Defect in Monozygotic Twins in Brazil

Neto¹,

Bereta²

2021

International Journal of Cardiovascular Sciences

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Tetralogy of Fallot (TOF) consists of four cardiac changes: interventricular communication, pulmonary stenosis, aortic dextroposition and right ventricular hypertrophy. The prevalence is 0.1 per 1,000 live births. A primiparous mother with gestational age of 38 weeks came to the emergency. At the time, it was verified in her twin pregnancy that one fetus had TOF, thus a pregnancy interruption was scheduled for the following day. In the neonatal physical examination of both, localized acrocyanosis, regular heart rhythm with the presence of a heart murmur, and good peripheral perfusion were found. The echocardiogram of twin 1 revealed: patent foramen ovale; a wide perimembranous interventricular communication of misalignment, with the aorta riding the septum by 50%; hypertrophied and long infundibulum with pulmonary infundibulo-valvular stenosis, with a maximum systolic gradient of 66 mm Hg; both pulmonary arteries presented dimensions of 0.35 mm; pulmonary valve annulus: 0.56 mm; and patent ductus arteriosus measuring 0.19 mm. The echocardiogram of twin 2 showed: patent foramen ovale; a wide perimembranous interventricular communication of misalignment, with the aorta riding the septum by 50%; hypertrophied infundibulum with stenosis pulmonary infundibulo-valve, with a maximum systolic gradient of 33 mm Hg; reduced confluent pulmonary arteries; right pulmonary artery measuring 0.40 mm and left pulmonary artery measuring 0.55 mm; pulmonary valve annulus measuring 0.72 mm; a closed arterial canal, and mild aortic regurgitation. Tetralogy of Fallot is a multifaceted syndrome with a high prevalence in pediatrics. This case is the first case of congenital heart defect concordance for TOF in monozygotic twins in Brazil.

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