2019
DOI: 10.1016/j.kint.2018.10.038
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Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy

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Cited by 65 publications
(70 citation statements)
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“…Urine N‐acetyl‐β‐ d glucosaminidase (NAG) was assessed using an automated colorimetric method (Pacific). Urinary creatinine and albumin were measured with a creatinine assay kit and an Albuwell M kit (Exocell) 24 …”
Section: Methodsmentioning
confidence: 99%
“…Urine N‐acetyl‐β‐ d glucosaminidase (NAG) was assessed using an automated colorimetric method (Pacific). Urinary creatinine and albumin were measured with a creatinine assay kit and an Albuwell M kit (Exocell) 24 …”
Section: Methodsmentioning
confidence: 99%
“…To our knowledge, we are the first to have found that tubular DsbA-L mediated UUO-induced TIF, renal cell apoptosis, and inflammation in mice. It is completely opposite to the role of DsbA-L in DN 17,18 ; the possible reason is that the difference between the role of system and tubular KO DsbA-L in DN and UUO model. In addition, we also found that DsbA-L mediated I/R, low-dose cisplatin, and aristolochic acid-induced TIF.…”
Section: Discussionmentioning
confidence: 85%
“…Previous studies have demonstrated that overexpression of DsbA-L has a renal-protective role against lipid-related kidney damage in DN 17 . In the current study, we initially induced DsbA-L in TGF-β1-treated BUMPT cells as well as in the kidneys of UUO mice and Ob patients, especially as the mitochondrion damage existed in the UUO model 27,28 ; we presumed that the expression of DsbA-L in kidney tubular injury was associated with the damage of mitochondrion damage (see Fig.…”
Section: Discussionmentioning
confidence: 97%
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“…Next, we sought to knockdown Smad4 in type 2 diabetes with established kidney disease. In this model, hypertensive eNOS À/À mice on the C57BL/ 6J background are placed on a high fat diet (HFD) for 30 weeks with a single STZ injection on week 8 to further increase blood glucose levels to diabetic state while remaining hyperinsulinaemia, a characteristic of type 2 diabetes [19][20][21][22][23][24][25][26][27][28][29][30][31]. This regimen results in hyperglycaemia, hyperinsulinaemia, albuminuria, glomerulosclerosis and reduced kidney function ( Fig EV1).…”
Section: Resultsmentioning
confidence: 99%