Disulfide interchange reactions: An enzymic case study

Abstract

This article concerns the reaction known as "disulfide interchange", in which a thiol reacts with a disulfide to give a different thiol and disulfide pair as the products. Such a reaction is a common occurrence in protein chemistry and enzymology; the specific case of the enzyme aldehyde dehydrogenase is chosen to illustrate various interesting manifestations of disulfide interchange.

Thione–thiol tautomerism and stability of 2- and 4-mercaptopyridines and 2-mercaptopyrimidines

“…Moreover, additional standing in indirect sunlight induces reversion to the initial disulfide as shown by eq. [2]: [2] Thione -disulfide dark This practical thiol-disulfide redox system could have some importance in biological systems and resembles the reaction known as "disulfide interchange" (23), in which a thiol reacts with a disulfide to give a different thiol and disulfide pair as products. Thus the disulfides 17 and 18 investigated have been extensively used for the modification and estimation of protein thiol groups (24).…”