Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

Wang, Tianbing; Guo, Kai; Zhang, Di; Wang, Haibo; Yin, Jiewei; Cui, Haodong; Wu, Wenyong

doi:10.1016/j.intimp.2023.110368

Cited by 68 publications

(37 citation statements)

References 59 publications

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“…This emerging form cell death may play a positive role in tumor growth and treatment resistance. Recent studies have reported the value of disul dptosis-associated genes in bladder cancer, breast cancer, and lung cancer, such as identifying tumor subtypes associated with disul dptosis, constructing relevant prognostic models, and screening potential therapeutic targets [14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

A disulfidptosis-related LncRNAs index predicting prognosis and tumor microenvironment in colorectal cancer

Xiao,

Yin,

Chen

et al. 2023

Preprint

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Colorectal cancer(CRC) is a common and deadly cancer in the world with a high lethality rate. Disulfidptosis has been found to be an emerging mode of death in cancer, and the purpose of this study to explore the relationship between disulfidptosis-related lncRNAs and CRC, developing a prognostic model for CRC. The gene expression data and clinicopathologic information of colorectal cancer patients was from The Cancer Genome Atlas(TCGA) and screened for disulfidptosis-related lncRNAs based on correlation analysis. Using the least absolute shrinkage and selection operator(LASSO) and Cox regression to construct the prognostic modeling, and its validation was carried out by PCA and receiver operating characteristic(ROC) curves. Also, we constructed the nomograms combining with the model. Finally, the possible mechanisms how to affect CRC by lncRNAs were explored by functional enrichment analysis, immune infiltration and immune escape analysis. In a word, we developed a prognostic marker consisting of lncRNAs associated with disulfidptosis to help clinicians predict the survival of different CRC patients and use different therapies depending on the conditions.

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Section: Discussionmentioning

confidence: 99%

A disulfidptosis-related LncRNAs index predicting prognosis and tumor microenvironment in colorectal cancer

Xiao,

Yin,

Chen

et al. 2023

Preprint

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“…In all, a total of 709 samples were ltered for the study. Fifteen disul dptosis-related genes (DRGs) were included based on a previous study: FLNA, FLNB, MYH9, TLN1, ACTB, MYL6, MYH10, CAPZB, DSTN, IQGAP1, ACTN4, PDLIM1, CD2AP, INF2, SLC7A11 (Wang T et al, 2023). Using these target genes, we screened 545 disul dptosisrelated lncRNAs (DRLs) by person correction analysis.…”

Section: Acquisition Of Datasets and Disul Dptosis-related Lncrnamentioning

confidence: 99%

Long noncoding RNA LINC01842 enhances disulfidptosis resistance and promotes glioma progression via IQGAP1

Zhang,

Wang,

Zheng

et al. 2024

Preprint

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Background: Long non-coding RNA (lncRNA) is widely present in cells and is demonstrated to play vital roles in the development and progression of glioma. However, the biological roles and function mechanisms of LINC01842 in glioma are not yet clear. This study aims to elucidate the potential role of LINC01842 in glioma, specifically its association with disulfidptosis. Methods: We obtained sequencing data from The Cancer Gene Atlas (TCGA). Correction analysis was applied to select disulfidptosis-related lncRNAs (DRLs). Prognosis-associated DRLs were identified by least absolute shrinkage and selection operator (LASSO) and support vector machine (SVM). Receiver operating characteristic (ROC) curve and multivariate Cox regression analyses were used to screen our target gene LINC01842. Subsequently, expression of LINC01842, IQGAP1and SLC7A11 in glioma cell lines was detected by real-time quantitative polymerase chain reaction (qPCR). Additionally, CCK8 experiments and wound healing assays were performed to assess cell viability, migration, and invasion. Finally, online database predictions were used to validate the drug sensitivity of glioma. Results: LINC01842 was more highly expressed in high-grade gliomas, and glioma patients with high expression level of LINC01842 had poorer survival. Additionally, tumor cells with high expression of LINC01842 exhibited stronger tumor characteristics, such as migratory and invasive abilities, as well as tolerance to disulfidptosis. Furthermore, strong binding between LINC01842 and the disulfidptosis-related gene IQGAP1 could be predicted, and their expression levels were positively correlated. Ultimately, drug sensitivity analysis suggested glioma patients with high expression level of LINC01842 were sensitive to eight drugs. Conclusion: High expression of LINC01842 is associated with poor prognosis in glioma patients. By interacting with IQGAP1, the resistance to disulfidptosis of LINC0182 was stronger in glioma, which promotes the progression of glioma. Eight discovered sensitive drugs provided important clues for personalized treatment of glioma.

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“…1.liver cancer: SPP1, MYBL2 [ 18 ]; SLC7A11 [ 19 , 20 ]; LRPPRC [ 20 ]; TNFRSF14, TNFRSF4, TNFSF4 [ 21 ], BTN2A1, BTN2A2 [ 21 ]; SLCO1B1 [ 22 ]…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

“…As research into the mechanisms of disulfidptosis continues, a growing body of evidence suggests a link to oncological conditions, neurological disorders, and bone metabolism abnormalities [ 18 – 46 ]. As a result, a thorough investigation of disulfidptosis mechanisms has significant clinical implications for the understanding and treatment of these conditions.…”

Section: Introductionmentioning

confidence: 99%

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Chen,

Ma,

Yang

et al. 2024

Biomark Res

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Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute carrier family 7 member 11 (SLC7A11) during glucose starvation. This accumulation causes extensive disulfide linkages between F-actins, resulting in their contraction and subsequent detachment from the cellular membrane, triggering cellular death. The RAC1-WRC axis is involved in this phenomenon. Disulfidptosis sparked growing interest due to its potential applications in a variety of pathologies, particularly oncology, neurodegenerative disorders, and metabolic anomalies. Nonetheless, the complexities of its regulatory pathways remain elusive, and its precise molecular targets have yet to be definitively identified. This manuscript aims to meticulously dissect the historical evolution, molecular underpinnings, regulatory frameworks, and potential implications of disulfidptosis in various disease contexts, illuminating its promise as a groundbreaking therapeutic pathway and target.

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Disulfidptosis classification of hepatocellular carcinoma reveals correlation with clinical prognosis and immune profile

Cited by 68 publications

References 59 publications

A disulfidptosis-related LncRNAs index predicting prognosis and tumor microenvironment in colorectal cancer

A disulfidptosis-related LncRNAs index predicting prognosis and tumor microenvironment in colorectal cancer

Long noncoding RNA LINC01842 enhances disulfidptosis resistance and promotes glioma progression via IQGAP1

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

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