2000
DOI: 10.1111/j.1530-0277.2000.tb04637.x
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Disulfiram Treatment Increases Plasma and Red Blood Cell Acetaldehyde in Abstinent Alcoholics

Abstract: In abstaining subjects given disulfiram, acetaldehyde concentrations increase, possibly due to diminished catabolism of endogenously generated acetaldehyde. Disulfiram should be given cautiously, especially in patients with cirrhosis.

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Cited by 10 publications
(4 citation statements)
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“…Its main function is to irreversibly block cytosolic and mitochondrial aldehyde dehydrogenases (Rossi et al, 2006), enzymes that are crucial for ACA catabolism. It is known that DSF induces accumulation of ACA in the human liver and blood (Rosman et al, 2000) as it does in a yeast cell. In this unicellular eukaryote model, we could show that this is lethal for WT cells and even more so for the pso2 mutant, which cannot complete the repair of ACA-induced DNA damage, most probably that of ICL ( Figure 2A and B).…”
Section: Discussionmentioning
confidence: 99%
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“…Its main function is to irreversibly block cytosolic and mitochondrial aldehyde dehydrogenases (Rossi et al, 2006), enzymes that are crucial for ACA catabolism. It is known that DSF induces accumulation of ACA in the human liver and blood (Rosman et al, 2000) as it does in a yeast cell. In this unicellular eukaryote model, we could show that this is lethal for WT cells and even more so for the pso2 mutant, which cannot complete the repair of ACA-induced DNA damage, most probably that of ICL ( Figure 2A and B).…”
Section: Discussionmentioning
confidence: 99%
“…Since it reacts with sulfhydryl groups, DSF has a broad spectrum of reactivity with blood components (Rossi et al, 2006). However, it is generally accepted that DSF blocks the catabolism of ethanol at the ACA oxidation step and thus leads to an increase in ACA in cells and in blood (Rosman et al, 2000).…”
Section: Discussionmentioning
confidence: 99%
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“…In individuals with aldehyde dehydrogenase (ALDH) 2 deficiencies, the buildup of acetaldehyde is thought to cause flushing, nausea, and headache [51][52][53][54]. Disulfiram, an ALDH inhibitor and alcohol use deterrent, also increases the buildup of acetaldehyde, which is thought to be the mechanism of action for reducing alcohol consumption [55][56][57].…”
Section: Acetaldehyde and Peracetic Acid: All Roads Lead To Acetic Ac...mentioning
confidence: 99%