Disuniting Uniformity: A Pied Cladistic Canvas of mtDNA Haplogroup H in Eurasia

Loogväli, Eva Liis; Roostalu, Urmas; Malyarchuk, B. A.; Derenko, Miroslava; Kivisild, Toomas; Metspalu, Ene; Tambets, Kristiina; Reidla, Maere; Tolk, Helle Viivi; Parik, Jüri; Pennarun, Erwan; Laos, S.; Lunkina, Arina; Golubenko, M. V.; Barać, Lovorka; Peričić, Marijana; Balanovsky, Oleg; Gusar, Vladislava; Хуснутдинова, Э. К.; Степанов, В. Г.; Puzyrev, V. P.; Rudan, Pavao; Balanovska, Elena; Grechanina, Elena; Richard, Christelle; Moisan, Jean-Claude; Chaventré, André; Anagnou, Nicholas P.; Pappa, Kalliopi I.; Michalodimitrakis, Emmanuel; Claustres, Mireille; Gölge, Mukaddes; Mikerezi, Ilia; Usanga, E.A.; Villems, Richard

doi:10.1093/molbev/msh209

Cited by 178 publications

(191 citation statements)

References 69 publications

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“…Although the highest frequency for the whole H1 was found in the Cantabrian Cornice as reported previously (Achilli et al, 2004;Loogvali et al, 2004;Pereira et al, 2005;Alvarez-Iglesias et al, 2009), diversity values were significantly higher in North-east Iberia in particular, and in the Mediterranean area in general. Furthermore, the allelic richness in the Cornice and in France is the lowest in all the studied range.…”

Section: Phylogeography Of H1 In the Cantabrian Cornice And Other Eursupporting

confidence: 83%

“…In this study, again, the high frequency of H4 and the absence of H3 resembles the haplogroup H profile found for Moroccan Berbers (Ennafaa et al, 2009). On the other hand, the high frequency of H1a may be better explained by northcentral European influence (Loogvali et al, 2004).…”

Section: Phylogeography Of H Subhaplogroups In the Cantabrian Cornicesupporting

confidence: 80%

“…Although a mtDNA analysis in ancient Basque populations questioned that interpretation (Izagirre and de la Rua, 1999), the posterior molecular dissection of mtDNA haplogroup H, the dominant lineage in Europe, identified two subhaplogroups (namely H1 and H3) that displayed frequency distributions and coalescence ages very similar to those previously reported for haplogroup V (Achilli et al, 2004). As these patterns were confirmed by several independent studies (Loogvali et al, 2004;Pereira et al, 2005;Alvarez-Iglesias et al, 2009), this human refuge theory to explain the post-glacial resettlement of Europe has gained almost unanimous support. However, in our opinion, the issue is not yet satisfactorily settled.…”

Section: Introductionsupporting

confidence: 57%

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Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge

Garcı́a¹,

Fregel

Larruga

et al. 2010

Heredity

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It has been proposed that the distribution patterns and coalescence ages found in Europeans for mitochondrial DNA (mtDNA) haplogroups V, H1 and H3 are the result of a post-glacial expansion from a Franco-Cantabrian refuge that recolonized central and northern areas. In contrast, in this refined mtDNA study of the Cantabrian Cornice that contributes 413 partial and 9 complete new mtDNA sequences, including a large Basque sample and a sample of Asturians, no experimental evidence was found to support the human refuge-expansion theory. In fact, all measures of gene diversity point to the Cantabrian Cornice in general and the Basques in particular, as less polymorphic for V, H1 and H3 than other southern regions in Iberia or in Central Europe. Genetic distances show the Cantabrian Cornice is a very heterogeneous region with significant local differences. The analysis of several minor subhaplogroups, based on complete sequences, also suggests different focal expansions over a local and peninsular range that did not affect continental Europe. Furthermore, all detected clinal trends show stronger longitudinal than latitudinal profiles. In Northern Iberia, it seems that the highest diversity values for some haplogroups with Mesolithic coalescence ages are centred on the Mediterranean side, including Catalonia and South-eastern France.

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Section: Phylogeography Of H1 In the Cantabrian Cornice And Other Eursupporting

confidence: 83%

Section: Phylogeography Of H Subhaplogroups In the Cantabrian Cornicesupporting

confidence: 80%

Section: Introductionsupporting

confidence: 57%

See 1 more Smart Citation

Using mitochondrial DNA to test the hypothesis of a European post-glacial human recolonization from the Franco-Cantabrian refuge

Garcı́a¹,

Fregel

Larruga

et al. 2010

Heredity

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“…A major proportion (94%) could be allocated to haplogroups H1, H3 and V, West Eurasian lineages of Iberian origin that spread to Europe 7,10,17,26,29,36 and most probably North Africa 30,31 with the improvement of the climatic conditions after the retreat of the ice sheets 15 000-13 000 years ago. Both H1 and H3 commonly display rather low diversity in the D-loop region, but the Tuareg haplotypes belonging to haplogroup V have a specific diagnostic mutation -the transition at position 16 234.…”

Section: Resultsmentioning

confidence: 99%

Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel

et al. 2010

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“…Nomenclature of African haplotypes follows Salas et al (2002Salas et al ( , 2004Salas et al ( ), with updates in Č erný et al (2007, Kivisild et al (2004), and Torroni et al (2006). For Native American haplogroups, we use the most updated nomenclature from Bandelt et al (2003) and Kong et al (2006), and for the European profiles, Achilli et al (2005Achilli et al ( , 2004, Loogväli et al (2004), and Sun et al (2006), among others. DnaSP 4.10.3 software (Rozas et al 2003) was used for computation of different diversity indices.…”

Section: Databases and Statistical Analysismentioning

confidence: 99%