Diterpene glycosides, acetophenone glycosides and tannins from polar extracts of the root of Euphorbia fischeriana with cytotoxicity and antibacterial activities

Natural-derived acetophenones: chemistry and pharmacological activities

“…The cytotoxicity activity of 180 and 181 were assessed against four lines of human cancer cells, namely Hela-60, MCF-7, A-549, and SMMC-7541, which elucidated the following results: 180 hindered the cell lines with the IC 50 values of 0.095, 6.85, 8.71, and 16.52 μg/mL in the same order, whereas 181 left its cytotoxic effects at the IC 50 values of 2.69, 0.346, 0.879, and 12.86 μg/mL, respectively [92]. Acetophenone glycosides: langduphenone A (182), langduphenone B (183), and langduphenone C (184) were extracted from E. fischeriana [93]. Compounds 182-184 were elucidated to possess inhibitory qualities against cancer cells and bacteria.…”

“…Compounds 182-184 were elucidated to possess inhibitory qualities against cancer cells and bacteria. Regarding the former, the isolated compounds were applied to five lines of cancer cells including Hep-G2, Hep-3B, A549, NCI-H460, and AGS; with the ternary MIC values listed as: (12.5, 6.25, 6.25), (6.25, 12.5, 3.12), (6.25, 3.12, 1.56), and (6.25, 3.12, 3.12) µg/mL, respectively [93]. Sun and Liu elucidated the structure of 2,4-dihydroxy-6-methoxy-1-acetophenone (185) and 2,4-Dihydroxy-6-methoxy-3-methylacetophenone (186) [94] which were originally isolated from E. fischeriana by che et al [95] and liu et al [96]…”

Insights into Euphorbia diversity: Probing the contrasts between Euphorbia fischeriana Steud and Euphorbia ebracteolata Hayata

“…In traditional Chinese medicine (TCM) , Euphorbia fischeriana Steud ( E. fischeriana ) and Euphorbia ebracteolata Hayata ( E. ebracteolata ), commonly referred to as “Langdu”, are widely extensively utilized for treating lymphatic tuberculosis and ringworm [ 1 ]. Both plant species are perennial herbaceous plants mainly distributed in northeastern China, Mongolia, Russia (Siberia), and Republic of Korea [ 2 ]. There have been many reports on the chemical constituents and pharmacological effects of the two plant species, which has made more and more researchers realize that there may be differences between E. fischeriana and E. ebracteolata .…”