Diterpenes and a flavone from Leucas neufliseana

Labdane diterpenoids from Marrubium vulgare

“…Known compounds were identified as marrubiin (Knöess and Zapp, 1998), peregrinin (Khalil et al, 1996;Piozzi et al, 2006), thessaline D (Argyropoulou et al, 2011;Hussein et al, 2003), marrubinone B (Iida et al, 1995), deacetylvitexilactone (Argyropoulou et al, 2011;Rigano et al, 2009), verbascoside (Delazar et al, 2011), leucosceptoside A (Delazar et al, 2011), martynoside ( Sahin et al, 2004), anisofolin A (Rao et al, 1982), terniflorin ( Nawwar et al, 1989), and apigenin (Chen et al, 2013;Sang et al, 1998) based on their NMR and mass spectrometry data, as well as in comparison with those reported in the literature. 12(S)-Hydroxymarrubiin, 3-deoxo-15(S)-methoxyvelutine C, marrubiin, peregrinin, and marrubinone B were evaluated for in vitro antimicrobial activity against a panel of bacterial (Staphylococcus aureus ATCC 29213, methicillin-resistant S. aureus (MRSA) ATCC 33591, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853 and Mycobacterium intracellulare ATCC 23068) and fungal (Candida albicans ATCC 90028, C. glabrata ATCC 90030, C. krusei ATCC 6258, Cryptococcus neoformans ATCC 90113, and Aspergillus fumigatus ATCC 204305) strains.…”

Essential oil composition of Leucas milanjiana Guerke

“…8 Labdane-type diterpenes, triterpenes and a flavone have been isolated and characterized from Leucas species of Indian origin. 9,10 From the roots of Leucas inflata has been isolated coumarleucasin and leucasone, while Leucas aspera has been shown to have prostaglandin inhibitory, antioxidant and analgesic activities. [11][12][13] Recently, the occurrence of monoterpenoid compounds using thin-layer chromatographic analysis of extracts from some Leucas RBr species growing in India (L. aspera Spreng, L, lavandulaefolia Rees, L. stricta Benth) was reported.…”

The Diterpenoids of the Genus Marrubium (Lamiaceae)

“…A novel furolabdane, anatolione (18), was isolated [55] (21). The last two products had been previously isolated from Leucas neufliseana [57], but not from a Marrubium species. Moreover, M. velutinum yielded five new diterpenoids: the inseparable epimeric mixtures of the hemiacetals velutine A ( 22 M. vulgare 1 , 3 [39], 4 [39], 5 [36], 7 [45,46], 8 [47], 27, 28 [36,39] a natural product, although it had been reported a long time ago [39] as a semisynthetic derivative prepared by chemical transformation of marrubiin.…”