Diterpenes from European Euphorbia Species Serving as Prototypes for Natural‐Product‐Based Drug Discovery

Abstract

A nanotemplate surface that functions as a regular array of traps for molecules such as naphthalocyanine (see picture) is provided by a nanomesh of hexagonal BN on Rh(111), which has now been identified as a single, complete monolayer. The 2‐nm‐sized pores form at regions where the layer binds strongly to the underlying metal, while the regular network of mesh wires corresponds to regions where the layer is not bonded to the substrate.

Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)

“…7 Besides this compound, other promising diterpenes (e.g. some phorbol and ingenol derivatives) are under clinical investigations.…”

Biologically active secondary metabolites from Asteraceae and Polygonaceae species

“…Much time has passed since a natural product without structural modification was introduced into clinical practice. 4 Several plant-derived agents are currently undergoing clinical development, among them flavopiridol, combretastatins and roscovitine.…”

LC-MS2-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

“…Diterpenoids isolated from Euphorbia species represent a unique group of structurally diverse compounds that possess remarkable biological activities [28][29][30][31][32], such as potent antiviral activity against human immunodeficiency virus (HIV) for tigliane- [33], ingenane- [29,34,35] and macrocyclic-type esters [36][37][38], or powerful P-glycoprotein modulation activity for macrocyclic diterpene esters [39,40].…”