Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Petiwala, Sakina M.; Johnson, Jeremy J.

doi:10.1016/j.canlet.2015.07.005

Cited by 113 publications

(69 citation statements)

References 71 publications

(82 reference statements)

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“…Carnosic acid, carnosol and rosmanol (Figure 8) may be the active components contained in rosemary responsible for its anti-cancer activity [217]. …”

Section: Rosemarymentioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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“…Carnosic acid, carnosol and rosmanol (Figure 8) may be the active components contained in rosemary responsible for its anti-cancer activity [217]. …”

Section: Rosemarymentioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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“…The main polyphenols found in rosemary extract (RE) include the diterpenes carnosic acid (CA) and rosmarinic acid (RA) [11]. Rosemary extract and its polyphenols CA and RA have recently been explored and found to exert potent anticancer effects (reviewed recently in [12,13,14]). To establish a systematic literature review we used the online search engine Pubmed.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols

2016

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Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. The exploration into natural products offers great opportunity to evaluate new anticancer agents as well as understand novel and potentially relevant mechanisms of action. Rosemary extract has been reported to have antioxidant, anti-inflammatory, antidiabetic and anticancer properties. Rosemary extract contains many polyphenols with carnosic acid and rosmarinic acid found in highest concentrations. The present review summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of rosemary extract and the rosemary extract polyphenols carnosic acid and rosmarinic acid, and their effects on key signaling molecules.

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“…For the first compound, MS/MS experiments gave rise to the product ion at m/z 299, which was previously suggested to derive from a neutral loss of CO 2 (Zhang et al, 2012). LC-MS/MS data for metabolite 15 suggested the likely presence of carnosol, a phenolic diterpene having a lactone ring, firstly characterized in 1964 and continuously investigated for its health promoting properties (Bauer et al, 2012;Chun, Kundu, Chae, & Kundu, 2014;Johnson, 2011;Petiwala & Johnson, 2015). In fact, the deprotonated pseudomolecular ion at m/z 329 fragmented to give product ions at m/z 285 (À44 Da), which in turn provided the ions at m/z 269 and 201 (Kontogianni et al, 2013).…”

Section: Phenolic Diterpenesmentioning

confidence: 96%