Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities

Yang, Li; Zhang, Yubo; Zhuang, Ling; Li, Tao; Chen, Neng‐Hua; Wu, Zhong‐Nan; Li, Pan; Wang, Guo‐Cai

doi:10.1055/s-0042-107252

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…Some lycoctonines, isolated from Aconitum , differentiate with diol at C7-C8 as compounds 63–73 in Figure 6 . Other lycoctonines characterise the presence of 7,8 methylenedioxy group ( 74–81 ), as shown in Figure 6 [ 22 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

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Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera. Corals, Xenia, Okinawan/Clavularia, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances. Compounds belonging to this unique and fascinating family of natural products exhibit a broad spectrum of biological activities. Some of these compounds are on the list of clinical drugs, while others act as incredibly potent neurotoxins. Despite numerous attempts to prepare synthetic products, this review only introduces the natural diterpenoid alkaloids, describing ‘compounds’ structures and classifications and their toxicity and bioactivity. The purpose of the review is to highlight some existing relationships between the presence of substituents in the structure of such molecules and their recognised bioactivity.

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Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

“…DAs 63–67 in Figure 6 show an O-acetamidobenzoate moiety [ 54 , 55 , 56 , 57 ]. DAs 65 and 66 exhibit hydroxyl substitution at C12 [ 54 ]. Tianshanitine B ( 68 ) has hydroxyl instead of methoxy in C16.…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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“…Four diterpenoid alkaloids, ajacisine C (49), ajacisine D (50), ajacisine E (51), and isodelectine (52), were isolated from Delphinium ajacis. Compounds 49-52 were evaluated for their in vitro antiviral activities against the respiratory syncytial virus, and compounds 49-52 exhibited moderate to weak effects with IC 50 values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 μM, respectively 59 (Figure 5).…”

Section: Extracts and Alkaloids From Plants With Anti-respiratory Synmentioning

confidence: 99%

Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation

Ti¹,

Zhuang²,

Yu³

et al. 2021

DDDT

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Viral infectious diseases are serious threats to human health in both developing and developed countries. Although there is the continued development of new drugs from synthetic sources as antiviral agents, medicinal plants continue to provide the basic raw materials for some of the most important antiviral drugs. Alkaloids are a class of pharmacologically active plant compounds that are usually alkaline in nature. In this review, we tried to summarize recent progress in herb-based antiviral research, the advantages of using active plant compounds as antiviral agents, and the inflammatory responses initiated by alkaloids, based on the literature from 2009 to 2019, for the treatment of conditions, including influenza, human immunodeficiency virus, herpes simplex virus, hepatitis, and coxsackievirus infections. Articles are retrieved from PubMed, Google Scholar, and Web of Science using relevant keywords. In particular, the alkaloids from medicinal plants responsible for the molecular mechanisms of anti-inflammatory actions are identified and discussed. This review can provide a theoretical basis and approaches for using various alkaloids as antiviral treatments. More research is needed to develop alkaloidal compounds as antiviral therapeutic agents and potential regulators of the anti-inflammatory response.

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“…According to our previous work, many alkaloids have been isolated from Delphinium grandiflorum [3,4]. The title compound, ajacisine D monohydrate, is one of the diterpenoid alkaloids which have been proved to be the main chemical components of genus Delphinium [5,6].…”

Section: Commentmentioning

confidence: 99%