Diterpenoid Alkaloids of Delphinium buschianumGrossh.

Abstract

From the aerial parts of Delphinium buschianum Grossh., collected in Turkey, a new diterpenoid alkaloid 1, named budelphine, was isolated along with the known diterpenoid alkaloids karakoline (2), 18‐hydroxy‐14‐O‐methylgadesine (3), delsoline (4), lapaconidine (5), columbianine (6), 14‐benzoylneoline (7), and hetisine (9). The structure of 1 was established on the basis of 1H‐, 13C‐, DEPT, 1H,1H‐COSY, NOESY, HSQC, and HMBC NMR studies.

C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

“…ex Poljakov in the family Compositae. 39 In addition, four lappaconitines were found in both Aconitum and Delphinium plants, namely, delphicrispuline (21), 40,41 lappaconidine (35), 26,42,43 puberanidine (41), [44][45][46] and sinomontanine A (50). 47,48 Most of the lappaconitine-type C 18 -DAs are scattered in certain Aconitum species with a narrow distribution, and only a few of them have a relatively wide distribution, such as aconosine (4), dolaconine (26), lappaconidine (35), and puberanidine (41).…”

An overview of the chemical constituents from the genus Delphinium reported in the last four decades

“…Alkaloids 31-38 contain an N-C (19) ]O lactam group, which might be formed by the carbonylation of 19-OH. [33][34][35][36][37] Budelphine (36) from D. buschianum possesses a rare 1,2-epoxy group. 36 There are 12 alkaloids (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) with an N-CHO formamide group formed from a C-21 aldehyde.…”

“…[33][34][35][36][37] Budelphine (36) from D. buschianum possesses a rare 1,2-epoxy group. 36 There are 12 alkaloids (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50) with an N-CHO formamide group formed from a C-21 aldehyde. 4,[38][39][40][41][42][43][44][45] Among these compounds, alkaloids 41-45 are DAs that have no oxygen-containing group at C-16.…”

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood

“…Delphinium anthriscifolium Hance is composed of alkaloids, fixed oils, lipoids, and glycosides. Delsoline and eldeline are the two main alkaloids of D. anthriscifolium Hance [ 3 – 5 ]. Delsoline has a curare-like effect and a ganglion-blocking effect and can be used to relieve muscle tension or hyperkinesia.…”