Diterpenoid Constituents of Teucrium scordium L. Subsp. scordioides (Shreb.) Maire Et Petitmengin

Abstract

A new scordidesin А (1) and 2 known furo-clerodane diterpenoids, teucrin A (2) and 6-ketoteuscordin (3), were isolated by the phytochemical investigation of the acetone extract from the aerial parts of Teucrium scordium L. subsp. scordioides (Lamiaceae). The structure and stereochemistry of the compounds were established by high-resolution electrospray ionization mass spectrometry, infrared spectroscopy, and various 1H nuclear magnetic resonance (NMR) and 2-dimensional-NMR techniques. Additionally, we report 13C NMR spectral data of 3 that were not published before. Antimicrobial activity of the compounds was tested against Gram-positive and Gram-negative bacteria belonging to 5 different species and against 2 strains of yeast belonging to 2 different species of the genus Candida.

Evaluación de la actividad antibacteriana in vitro y en invernadero de extractos de Salvia amarissima contra Clavibacter michiganensis subsp. michiganensis

“…A continuación, en efectividad siguieron los tratamientos T13-T15, que fueron estadísticamente iguales y mostraron diferencias respecto a los testigos, y fueron mejores que el control químico (T16= 233.4 x 10 7 CFU/mL), por lo que se recomienda el uso de las fracciones STJ-1 y 3 a 25 μg/mL para controlar el crecimiento de Cmm (Tabla 3). Estos resultados se relacionan con los trabajos de Bozov et al, (2020) que aislaron un nuevo diterpenoide neoclerodano y dos diterpenoides furo-clerodano de las partes aéreas de Camedrio acuático (Teucrium scordium, Lamiaceae) y probaron su actividad antibacteriana y antifúngica contra varios patógenos, encontrando actividades similares contra las especies bacterianas como S. aureus, S. pyogenes, L. monocytogenes, E. coli y S. abony con valores de concentración mínima inhibitoria (MIC) oscilando entre 250 y 500 μg /mL (Bozov et al, 2020). Por otro lado, Fozia et al (2021), aislaron dos nuevos diterpenos de marrubio (Ballota pseudodictamnus, Lamiaceae); los ácidos ballodiólicos A y B, y se probaron para determinar su actividad antibacteriana contra E. coli y S. typhi.…”

Antimicrobial Diterpenes: Recent Development From Natural Sources

“…The novel compound scordidesin ( 23 ) ( Figure 3 ) and previously identified compound teucrin A ( 24 ) were tested for both antibacterial and antifungal activities against several bacterial and fungal species. Both compounds showed similar activities against the bacterial species only, with MIC values ranging between 250 and 500 μg/ml ( Bozov et al, 2020 ).…”