Diterpenoids and Sesquiterpenoids from the Roots of <i>Illicium majus</i>

Wang, Ya-Dan; Zhang, Guijie; Qu, Jing; Li, Yuhuan; Jiang, Jian‐Dong; Liu, Yun‐Bao; Ma, Shuang‐Gang; Li, Yong; Lv, Haining; Yu, Shi‐Shan

doi:10.1021/np400638r

Cited by 32 publications

(16 citation statements)

References 32 publications

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“…Similarly, studies carried out with essential oils from SA also showed interesting results with respect to its antiviral effects. Studies Wang et al, 2013) carried out with the anise oil along with two other essential oils (dwarf-pine oil and chamomile oil) against different types of thymidine-kinase such as thymidine-kinase-positive (aciclovir-sensitive) and thymidine-kinasenegative (aciclovir-resistant) herpes simplex virus Type 1 (HSV-1) showed that all these essential oils have antiviral activity against the aciclovirsensitive HSV strain KOS and aciclovir-resistant clinical HSV isolates as well as aciclovir-resistant strain Angelotti, through interrupting the adsorption of herpes viruses. This is different from the mode of action of aciclovir, which is effective after attachment inside the infected cells.…”

Section: Antiviral Effects Of Active Constituents From Samentioning

confidence: 99%

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

Patra

Das

Bose³

et al. 2020

Phytotherapy Research

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Medicinal herbs are one of the imperative sources of drugs all over the world. Star anise (Illicium verum), an evergreen, medium-sized tree with star-shaped fruit, is an important herb with wide distribution throughout southwestern parts of the Asian continent. Besides its use as spice in culinary, star anise is one of the vital ingredients of the Chinese medicinal herbs and is widely known for its antiviral effects. It is also the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu ® ), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, antiinflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects. This review aimed to integrate the information on the customary attributes of the plant star anise with a specific prominence on its antiviral properties and the phytochemical constituents along with its clinical aptness. K E Y W O R D S antiviral, Illicium verum, oseltamivir, shikimic acid, star anise, Tamiflu

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Section: Antiviral Effects Of Active Constituents From Samentioning

confidence: 99%

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

Patra

Das

Bose³

et al. 2020

Phytotherapy Research

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“…angustanoic acid F) 21 and majusanic acids ( e.g. majusanic acids B, D, E and F) 22 have shown to possess antiviral activity against Coxsackie B viruses.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical study of Illicium angustisepalum and its biological activities

Szymulanska-Ramamurthy

Zhao

Tao

2017

Acta Pharmaceutica Sinica B

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Sixteen compounds, including two new natural products (1 and 2), were obtained from the twigs of Illicium angustisepalum. The structures were elucidated based on NMR, MS, IR data and optical rotation values. Compounds 4, 5, 6 and 8 displayed moderate antibacterial activities against clinical isolates; compounds 4, 5, 8, 9 and 15 protected neural cells against oxidative stress; and compounds 10 and 14 exhibited anti-acetylcholinesterase activity.

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“…Even though all parts of the tree have been classified as toxic by botanists, the roots, leaves and bark of I. majus are used in folk medicine to promote blood circulation, relive pain, dispel wind, and treat rheumatic arthritis [1,2] . To date, various seco‐prezizaane‐type sesquiterpenes, diterpenes, prenylated C 6 –C 3 compounds, and lignans have been isolated from the different parts of this plant, [3,4] and among them, only three glycosides have currently been reported from this plant [1–6] . In our continuing work to discover new bioactive constituents from the Illicium genus, we carefully investigated the high‐polarity components (BuOH fraction) of the ethanol extract of I. majus , expecting to separate more natural active products.…”

Section: Introductionmentioning

confidence: 99%

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

Yan

et al. 2021

Chemistry & Biodiversity

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Chemical investigation of the ethanol extract of the branch and leaves of Illicium majus resulted in the isolation of four new phenylpropanoid glycosides (1–4) and one new phenolic glycoside (9), along with 13 known ones. Spectroscopic techniques were used to elucidate the structures of the new isolates such as 3‐[(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐(hydroxymethyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl β‐D‐glucopyranoside (1), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐glucopyranoside (2), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐xylopyranoside (3), 3‐[(2R,3S)‐3‐({[2‐O‐(4‐O‐acetyl‐α‐L‐rhamnopyranosyl)‐β‐D‐xylopyranosyl]oxy}methyl)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl acetate (4), and 4‐(2‐hydroxyethyl)phenyl 3‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (9). Free radical scavenging activities of the isolates were elucidated through the DPPH assay method. The most active compounds, 1‐O‐caffeoyl‐β‐D‐glucopyranose (17) and soulieana acid 1 (18), exhibited moderate radical scavenging activities (IC50=37.7±4.4 μM and IC50=97.2±3.4 μM, respectively). The antibacterial activities of the isolates against Staphylococcus aureus and Escherichia coli were also assessed, and no activity was shown at the measured concentration (<32 μg/mL).

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Diterpenoids and Sesquiterpenoids from the Roots of Illicium majus

Cited by 32 publications

References 32 publications

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance

Phytochemical study of Illicium angustisepalum and its biological activities

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

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