Diterpenoids from Cephalotaxus fortunei var. alpina and their cytotoxic activity

Total Synthesis of (+)‐3‐Deoxyfortalpinoid F, (+)‐Fortalpinoid A, and (+)‐Cephinoid H

“…The structural diversity is primarily derived from differences in the A ring; notably, tropone is the fundamental structure of the A ring [1, 2] . Furthermore, this tropone moiety is essential for the cytotoxicity of multiple Cephalotaxus diterpenoids [2e,i,j,l] . In addition to the A ring, a tetrahydrofuran ring (F ring) is present in some Cephalotaxus diterpenoids.…”

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

“…To this day, many chemical constituents with novel structures and significant biological activities have been obtained from the genus. [2][3][4][5][6][7][8] Cephalotaxus genus plants possess various structural types mainly including alkaloids, flavonoids, terpenoids, lignans and phenylpropanoids, some of which showed antitumor, antiviral, antimicrobial, antimalarial, and antioxidant activities. Harringtonine (HT) and homoharringtonine (HHT) have been developed into anticancer drugs, which have remarkable therapeutic effects on acute nonlymphocytic leukemia and chronic myelogenous leukemia.…”

Semi-Synthesis of Harringtonolide Derivatives and Their Antiproliferative Activity

“…Cephalotane-type diterpenoids are widely distributed in the plant of the Cephalotaxus genus [ 1 , 2 , 3 , 4 , 5 ], which is the sole member of the Cephalotaxaceae family. Harringtonolide (also named as hainanolide, HO) is the first member of cephalotane-type diterpenoids that was isolated and structurally identified in 1978 from the seeds of Cephalotaxus harringtonia by Buta and coworkers.…”