Diterpenoids of Nepeta tuberosa subs. Reticulata

Argolic Acid A and Argolic Methyl Ester B, Two New Cyclopentano-monoterpenes Diol from Nepeta Argolica

“…This suggestion is supported by the presence of structurally related cyclopentano-monoterpene enol acetates in the aerial parts of Nepeta leucophylla [9]. Based upon spectroscopic studies, compounds 3 and 4 were identified as 1α,2β,5α-nepetonic acid [10] and 1,5,9-epideoxyloganic acid [12].…”

“…sibthorpii) is an aromatic plant, endemic of the South Balkan peninsula. Its essential oil composition was previously investigated by GC-MS and the methanolic extract was found to have anti-inflammatory activity [8][9][10]. In this paper we report the isolation and structural determination of two new compounds, argolic acid A (1) and argolic methyl ester B (2) and the known compounds, 1α-2β-5α−nepetonic acid (3) [10], 1,5,9-epideoxyloganic acid (4) [11], 4',5-dihydroxy-6,7-dimethoxy-flavone [12] and luteolin [13].…”

Constituents ofNepetacaesarea

“…Hydrolysis of 1 afforded 3R-hydroxy-4aR,7R,7aR-dihydronepetalactone (nepetalic acid) and β-sitosterol. A previous study, by Urones et al., 12 compound 1 was identified as 3′R-[β-sitosteryl-3β-oxy]dihydronepetalactone.…”

“…Hydrolysis of 1 afforded 3α-hydroxy-4aα,7α,7aα-dihydronepetalactone (nepetalic acid) and β-sitosterol. A previous study, by Urones et al., yielded isopimarol derivatives having nepetalactone moieties from Nepeta tuberosa subsp. reticulata.…”