2015
DOI: 10.1039/c4np00108g
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Diterpenoids of terrestrial origin

Abstract: This review covers the isolation and chemistry of diterpenoids from terrestrial as opposed to marine sources and includes labdanes, clerodanes, abietanes, pimaranes, kauranes, cembranes and their cyclization products. There are 214 references.

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Cited by 33 publications
(21 citation statements)
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“…However, we presume that this compound is also originated from the syn-copalyl carbocation and that a labdane related diterpene with high structural similarity to syn-labda-8(17),12E,14-triene was generated by the ACS mutants. The newly generated diterpenes are of great interest as copalol derivatives display various biological activities analogous to aphidicolin (Hanson, 2015 ).…”
Section: Resultsmentioning
confidence: 99%
“…However, we presume that this compound is also originated from the syn-copalyl carbocation and that a labdane related diterpene with high structural similarity to syn-labda-8(17),12E,14-triene was generated by the ACS mutants. The newly generated diterpenes are of great interest as copalol derivatives display various biological activities analogous to aphidicolin (Hanson, 2015 ).…”
Section: Resultsmentioning
confidence: 99%
“…Natural products have played a major role in new drug discovery for centuries, with over 47% of approved anticancer agents being of natural origin [6]. Due to the special structures and diverse biological properties, diterpenoids have attracted much attention of researchers [7]. Plants belonging to Euphorbiaceae families are widely applied in traditional Chinese medicine because these families have rich sources of diterpenoids [8].…”
Section: Introductionmentioning
confidence: 99%
“…Plants are normally an important source of new drugs [2]. In recent years, Isodon genus members have been promising leads due to their extensive pharmacological and physiological effects, such as inhibition of hepatitis viral replication [3] and bacterial infections of the lung or gut [4], as well as its antimalaria [5], antiinflammatory [6], and anti-tumor properties [7]. Hitherto, over 1200 ent -Kaurane-type diterpenoids with highly compact polycyclic ring systems have been isolated from Isodon genus, notably the compounds oridonin [8].…”
Section: Introductionmentioning
confidence: 99%