Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique

Nayak, Brusabhanu; Dogra, Prem Nath; Naswa, Niraj; Kumar, Rakesh

doi:10.1007/s00259-012-2294-6

Cited by 87 publications

(50 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies of PET/CT using this approach have shown that bladder tumors indeed are consistently FDG avid and can be well visualized by PET. 12,13 In addition, small metastatic pelvic lymph nodes have been reported to exhibit increased activity using 18 F-FDG PET/CT, further supporting the potential value of PET for bladder cancer assessment. 14,15 …”

mentioning

confidence: 85%

“…A number of investigations have explored a forced diuresis protocol entailing, most commonly, oral hydration, IV diuretic administration, and subsequent voiding, performed between radiotracer administration and PET imaging. 9,11,12 This approach is intended to achieve clearance of excreted FDG from the bladder lumen while allowing for persistent uptake within the bladder wall itself. Recent studies of PET/CT using this approach have shown that bladder tumors indeed are consistently FDG avid and can be well visualized by PET.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Coregistration Accuracy of Pelvic Structures Between Sequential and Simultaneous Imaging During Hybrid PET/MRI in Patients with Bladder Cancer

Rosenkrantz

Balar²,

Huang³

et al. 2015

Clinical Nuclear Medicine

View full text Add to dashboard Cite

Purpose The aim of this study was to compare coregistration of the bladder wall, bladder masses, and pelvic lymph nodes between sequential and simultaneous PET and MRI acquisitions obtained during hybrid 18F-FDG PET/MRI performed using a diuresis protocol in bladder cancer patients. Methods Six bladder cancer patients underwent 18F-FDG hybrid PET/MRI, including IV Lasix administration and oral hydration, before imaging to achieve bladder clearance. Axial T2-weighted imaging (T2WI) was obtained approximately 40 minutes before PET (“sequential”) and concurrently with PET (“simultaneous”). Three-dimensional spatial coordinates of the bladder wall, bladder masses, and pelvic lymph nodes were recorded for PET and T2WI. Distances between these locations on PET and T2WI sequences were computed and used to compare in-plane (x-y plane) and through-plane (z-axis) misregistration relative to PET between T2WI acquisitions. Results The bladder increased in volume between T2WI acquisitions (sequential, 176 [139]mL; simultaneous, 255 [146]mL). Four patients exhibited a bladder mass, all with increased activity (SUV, 9.5–38.4). Seven pelvic lymph nodes in 4 patients showed increased activity (SUV, 2.2–9.9). The bladder wall exhibited substantially less misregistration relative to PET for simultaneous, compared with sequential, acquisitions in in-plane (2.8 [3.1]mm vs 7.4 [9.1]mm) and through-plane (1.7 [2.2]mm vs 5.7 [9.6]mm) dimensions. Bladder masses exhibited slightly decreased misregistration for simultaneous, compared with sequential, acquisitions in in-plane (2.2 [1.4]mm vs 2.6 [1.9]mm) and through-plane (0.0 [0.0]mm vs 0.3 [0.8]mm) dimensions. FDG-avid lymph nodes exhibited slightly decreased in-plane misregistration (1.1 [0.8]mm vs 2.5 [0.6]mm), although identical through-plane misregistration (4.0 [1.9]mm vs 4.0 [2.8]mm). Conclusions Using hybrid PET/MRI, simultaneous imaging substantially improved bladder wall coregistration and slightly improved coregistration of bladder masses and pelvic lymph nodes.

show abstract

mentioning

confidence: 85%

mentioning

confidence: 99%

Comparison of Coregistration Accuracy of Pelvic Structures Between Sequential and Simultaneous Imaging During Hybrid PET/MRI in Patients with Bladder Cancer

Rosenkrantz

Balar²,

Huang³

et al. 2015

Clinical Nuclear Medicine

View full text Add to dashboard Cite

show abstract

“…The optimum or specific isotope for studying bladder cancer has not yet been determined (34 (15,(35)(36)(37)(38). FDG is still the most widely used isotope to investigate bladder cancer (34).…”

Section: Transurethral Resectionmentioning

confidence: 99%

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Aljabery¹

2017

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Aim: To study the possibility of detecting lymph node metastasis in locally advanced urinary bladder cancer (UBC) treated with radical cystectomy (RC) by using preoperative positron emission tomography/computed tomography (PET/CT) and peroperative sentinel node biopsy (SNB) technique. We also investigate the clinical significance of macrophage traits expression by cancer cells, M2-macrophage infiltration (MI) in tumor stroma and the immunohistochemical expression of biomarkers in cancer cells in relation to clinico-pathologic data. Patients and Methods:We studied prospectively 122 patients with UBC, pathological stage pT1-pT4 treated with RC and pelvic lymph node dissection (PLND) during [2005][2006][2007][2008][2009][2010][2011] at the Department of Urology, Linköping University Hospital. In the first study, we compared the results of preoperative PET/CT and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes (LNs). In the second study we investigated the value of SNB technique for detecting pathological LNs during RC in patients with UBC. We also examined the significance of the primary tumor location in the bladder in predicting the site of LN metastases, and the prognostic significance of lympho-vascular invasion (LVI) and lymph node metastasis density (LNMD) on survival. In the third study, we investigate the clinical significance of macrophage infiltration (MI) in tumor stroma and macrophage-traits expression by tumor cells. In the fourth study, we investigate the cell cycle suppression pro-

show abstract

“…Ancak, oral hidrasyon, intravenöz diüretik kullanımı ve miksiyon sonrasında mesane lümenine uzanan mural lezyonlarda fokal FDG tutulumu izlenebilmekte, mesane kanserlerinin bölgesel değerlendirmesi kısmen yapılabilmektedir (123). Yine de FDG PET görüntülemenin mesane kanserlerinde esas rolü, uzak metastaz varlığının araştırılması, cerrahi sonrası rekürren hastalık varlığının belirlenmesi ve neoadjuvan kemoterapi yanıtının değerlendirilmesidir (14).…”

Section: Mesanekanserindepet/mrunclassified

Positron Emission Tomography/Magnetic Resonance Imaging Practices in Oncological Imaging

Aydos¹,

Akdemir²,

Atay³

2017

Nts

View full text Add to dashboard Cite

Tıbbi onkolojide tanı, evreleme, biyopsi yerinin saptanması, prognostik değerlendirme, tedavi planı seçimi, tedaviye yanıtın değerlendirilmesi, rekürren hastalık saptanması gibi durumlarda görüntüleme yöntemleri gittikçe artan bir yere sahiptir. Moleküler görüntüleme verileri ile anatomik görüntüleme verilerini bir araya getiren hibrit görüntüleme tekniklerinin üçüncü aşaması olan pozitron emisyon tomografisi/ manyetik rezonans (PET/MR) görüntüleme yöntemi, MR görüntülemenin yüksek rezolüsyonlu anatomik görüntülerini, fonksiyonel görüntüleme verilerini, florodeoksiglukoz (FDG) ve FDG dışı ajanlarla yapılan PET görüntülemenin sağladığı moleküler bilgileri birleştirerek primer tümör evrelemesi, tedavi yanıtının değerlendirilmesi, hastalık rekürrensinin saptanmasında yüksek tanısal doğruluk potansiyeline sahiptir. Bunlara ek olarak, PET ve MR görüntülemenin eş zamanlı olarak yapılabilmesi görüntüleme sürelerinin kısaltılmasında, hareket artefaktlarının düzeltilmesinde yararlı olabileceği gibi, tekrarlayan görüntüleme gerektiren hastalarda PET/ MR görüntüleme PET/BT'ye göre iyonize radyasyon dozunun azaltılmasında da etkilidir. MR görüntülemenin yüksek yumuşak doku kontrastı nedeniyle beyin tümörlerinde, baş-boyun tümörlerinde, yeni tanı meme kanserlerinde, yeni tanı akciğer kanserlerinde beyin metastazı varlığının araştırılmasında, abdominopelvik tümörlerde, hematolojik malignitelerde intramedüller alanın değerlendirilmesinde PET/MR görüntüleme PET/BT'ye tercih edilebilir ya da bölgesel görüntüleme şeklinde tamamlayıcı nitelikte kullanılabilir. PET/ BT ise MR görüntülemenin kontrendike olduğu durumlarda primer tümör evrelemesinde ve özellikle nodüler akciğer

show abstract

Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique

Cited by 87 publications

References 16 publications

Comparison of Coregistration Accuracy of Pelvic Structures Between Sequential and Simultaneous Imaging During Hybrid PET/MRI in Patients with Bladder Cancer

Comparison of Coregistration Accuracy of Pelvic Structures Between Sequential and Simultaneous Imaging During Hybrid PET/MRI in Patients with Bladder Cancer

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Positron Emission Tomography/Magnetic Resonance Imaging Practices in Oncological Imaging

Contact Info

Product

Resources

About