Diuretic Activities of Root Bark Aqueous and Ethanolic Extracts of Parquetina nigrescens: I-Effects on Urinary Excretion in Wistar Rat

Konan, Brou André; Kpahé, Ziéhi Fidèle; Koko, Koffi Bruno; Adepo, Yapo Prosper

doi:10.22270/jddt.v12i3.5318

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The increase in the urine volume excreted could ascetically justify the use of the plant in the treatment of hypertension and edema. Further studies are needed to clarify the mechanism of the diuretic activity of the plant [ 84 ].…”

Section: Resultsmentioning

confidence: 99%

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Adase

Ankutse²,

Kumadoh

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The development of herbal medicines as a remedy for several illnesses has been recognized and accepted worldwide by health experts. Parquetina nigrescens is a perennial evergreen woody climber from the Apocynaceae family, widely used in Africa for the treatment of many diseases. The current study is intended to review and put together information available on this ethno-medicinal plant, which will improve scientific knowledge about the plant and also identify research areas that need to be investigated further. The information related to the plant was obtained using scientific databases such as Google scholar, WebMD, Wiley, Science direct, Cochrane database, student thesis, PubMed, and Scopus to obtain relevant literature regarding the botanical descriptions and distribution of the plant, traditional uses, phytochemicals, active compounds isolated from the plant, and pharmacological properties of P. nigrescens. Several traditional uses for different parts of the plant (leaves, stem bark, roots, leaf sap, flowers, and latex) have been presented. A review of the phytochemical composition of different plant parts revealed the presence of reducing sugars, flavonoids, tannins, alkaloids, cardiac glycosides, steroids, coumarin, anthraquinones, terpenoids, and saponins. Many studies also highlighted pharmacological activities related to P. nigrescens, including antianemic and haematological activity, antidiabetic, anti-inflammatory, antipyretic, analgesic, antiasthmatic, antimicrobial, insecticidal, neurotoxic, cytotoxic, antityphoid, antipolycystic ovarian syndrome activity, antilipidemic, and memory-enhancing activity. It is recommended that further in-vivo and clinical studies be conducted on the plant for the development of novel drugs.

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Section: Resultsmentioning

confidence: 99%

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Adase

Ankutse²,

Kumadoh

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…In case of uncomplicated high blood pressure, the combination of thiazide and a potassium sparer at a low-dose is required [2]. The hypotensive and antihypertensive effects of diuretics are based on their actions, combined or not, on the cardiovascular system and on blood volume [3]. Diuretics are pharmacological substances that increase natriuresis and lead to an increase in isoosmotic sodium urinary excretion.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Diuretic Activity of Petroselinum Crispum Aqueous Leaves Extract in Wistar Rats

Atto,

Koko,

Kamo

et al. 2024

Azb Pharm Pharmaco J

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Objective: This research work aims to contribute to the valorization of plants used in traditional medicine to improve populations health. It was particularly a question of evaluating the therapeutic effectiveness of the aqueous extract of leaves of Petroselinum crispum (Apiaceae), a plant traditionally used for its diuretic effect. Methods: Five groups of four 18h-fasted rats and under water overload using a 0.9% NaCl saline solution were treated separately with the saline solution, Furosemide (Furo 40 mg/kg) and 3 increasing doses of Petroselinum crispum aqueous leaves extract (PcAE 500, 100 and 1500 mg/kg). The quantities of urine collected at 2 h intervals for 24 h determined, electolytes and biochemical markers of the kidney were measured. Results: PcAE led to a dose-dependent increase in urinary excretion. At a dose of 1500 mg/kg, it induced, 24 hours after administration, a statistically significant increase in urinary excretion compared to control rats having received only the saline solution (34.99 ± 8.46 ml/kg). The urinary excretion produced was statistically similar to that of Furo 40 mg/kg. This excretion was gone with an elimination of Na+ and K+. Also the determination concentration of creatinine and urea in the urine revealed that the plant extract did not disrupt the renal function during treatment. Conclusion: Petroselinum crispum aqueous leaves extract has an diuretic and natriuretic activity similar to that of the furosemide. This activity would be conferred by the presence of alkaloids and flavonoids.

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“…It is in this context that the present work has been carried out in order to study the acute toxicity of the aqueous extract of the leaves of this medicinal plant in the female Wistar rat. The extraction process was implemented according to the method described by some authors [25][26][27][28] . The fresh leaves were washed and dried at room temperature (28 ± 2 °C).…”

Section: Introductionmentioning

confidence: 99%

Oral and Intraperitoneal Acute Toxicity Studies of Sesamum radiatum Aqueous Leaf Extract in Female Wistar Rats

Kouacou

Konan

Koko

2022

J. Drug Delivery Ther.

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Background and aims: Sesamum radiatum leaves are commonly used by African and Ivorian people in particular to treat various diseases. However, few studies have been done on the pharmacological properties and even less on the acute toxicity of this medicinal plant in Côte d'Ivoire. Also, the present work was carried out in order to contribute to correcting this through a comparative study of the acute oral and intraperitoneal toxicity of the aqueous extract of the leaves (ESera) in the female Wistar rat. Méthodes: According to the modified OECD 423 method, 2 groups of 6 rats were treated with ESera at 50 mg/kg and 2000 mg/kg in a single dose respectively by intraperitoneal and oral administration in comparison with the control group (NaCl 0.9 %). Dice weighing at regular intervals of 2 days of body weight and the removal of some organs and blood samples at the end of the 14-day observation period allowed the measurement of biological parameters. Results: Irrespective of the administration route, ESera did not cause clinical signs of suffering, behavior change and death in rats. The morphology and the relative weight of the organs (heart, kidneys, liver and lungs) were not modified. Treated animals exhibited weight growth kinetics similar to those of the controls. Greater weight gains (p < 0.05) were obtained with ESera. The study carried out on the blood samples showed statistically significant changes (p < 0.05) in certain hematological and serum biochemical parameters. The changes observed were greater with ESera 50 mg/kg intraperitoneal administration. Conclusion: Sesamum radiatum aqueous extract did not cause death or organ changes in rats during the 14 days of observation.However, in order to better determine its toxicity, other studies must be carried out due to the disturbances observed in hematological parameters, transaminases and electrolytes. Keywords: Acute toxicity, Hematological parameters, Biochemical parameters, Organ biometry

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Diuretic Activities of Root Bark Aqueous and Ethanolic Extracts of Parquetina nigrescens: I-Effects on Urinary Excretion in Wistar Rat

Cited by 4 publications

References 15 publications

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

“A Review of Parquetina nigrescens (Afzel.) Bullock, A Plant for Traditional Medicine: Phytochemical and Pharmacological Properties”

Assessment of the Diuretic Activity of Petroselinum Crispum Aqueous Leaves Extract in Wistar Rats

Oral and Intraperitoneal Acute Toxicity Studies of Sesamum radiatum Aqueous Leaf Extract in Female Wistar Rats

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