Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme: An in vivo and in silico Investigation

IL-6 Inhibitory Compounds from the Aerial Parts of Piper attenuatum and Their Anticancer Activities on Ovarian Cancer Cell Lines

“…The known compounds were determined to be (-)-dimethylmatairesinol (4) [21], (-)-kusunokinin (5) [22], (-)-haplomyrfolin (6) [23], piperdardine (7) [24], piperine (8) [25], piperanine (9) [25], guineensine (10) [25], (6S)-dehydrovomifoliol (11) [26], (-)-loliolide (12) [27], piperolactam A (13) [28], aristolactam BII (14) [29], p-hydroxybenzoic acid (15) [30], vitexin ( 16) [31], ficuflavoside (17) [32], and vitexin 2 ′′ -O-β-D-glucopyranoside (18) [33] by comparing their spectral data with that reported in the literature.…”

“…Renowned for its distinctive taste and scent, the Piper species holds widespread acclaim as a popular spice with considerable economic significance [3], and P. attenuatum is a plant called oval-leaved pepper, which can be used as an alternative to black pepper (P. nigrum) [4,5]. The leaves and roots of P. attenuatum are traditionally used to treat malaria, headache, hepatitis, mechanical injury, muscular pain, and pulmonary and urinary disorders [6][7][8].…”

“…The studies of the chemical composition of P. attenuatum have identified alkaloids, amides lignans, neolignans, and terpenes [7,9]. A few research groups have investigated the biological activities of P. attenuatum extracts, but there have been no systematic studies on the chemical identification of its biological activities.…”

“…A few research groups have investigated the biological activities of P. attenuatum extracts, but there have been no systematic studies on the chemical identification of its biological activities. However, several studies have shown that P. attenuatum exhibits antibacterial, anticancer, antidiabetic, anti-inflammatory, antipyretic, diuretic, hepatoprotective, and hyperlipidemic activities [7].…”