Diuretic activity of Fabiana patagonica in rats

Abstract

A pharmacological evaluation of the diuretic activity of Fabiana patagonica Speg. (Solanaceae) was carried out in isotonic saline loaded rats. The data reported in the present work indicate that the acetone extract and infusion of the aerial part of Fabiana patagonica showed a moderate diuretic activity. This activity could be due, in part, to the presence of oleanolic acid isolated as the major metabolite of F. patagonica.

Herbal medicines as diuretics: A review of the scientific evidence

“…Leaf extracts evoked no changes in diuresis or natriuresis. Whether their actives have diuretic effects need further attention (i.e., oleanolic acid, Alvarez et al, 2002Alvarez et al, , 2003Somova et al, 2003 andpolyphenols, Singh et al, 2007). Studies should also address the effect of differing doses.…”

Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways

“…OA is prevalent in Oleaceae family, especially in olive (O. europaea), the plant species after which the compound was named and that still serves as the main source of commercial OA (Pollier & Goossens, 2012;Sporn et al, 2011). Many pharmacological activities of OA have been reported such as antifungal (Tang et al, 2000), insecticidal (Marquina et al, 2001), anti-HIV (Ma et al, 2000), diuretic (Alvarez et al, 2002), complement inhibitory (Assefa et al, 2001), liver-protection (Yim et al, 2001), anti-inflammatory (Ismaili et al, 2001) and gastrointestinal transit modulating activities (Li et al, 1999). In recent years, it was found that OA exhibited the significant antitumor effect and cytotoxic activity toward many cancer cell lines such as liver cancer cells, colon carcinoma cells and fibrosarcoma cells (Li et al, 2002;Yan et al, 2010).…”

<i>In Vitro</i> Propagation and Conservation of <i>Zeyheriamontana</i> Mart: An Endangered Medicinal Plant

“…(bolsa de pastor) a plant native to Brazilian Cerrado, extends beyond the phytotherapeutic use. Its leaves produce ursolic, oleanolic and betulic acids, pentacyclictriterpenoids, with validated biological properties, such as anticancer activity [1], inhibitory effects on NO production and iNOS induction [2], anti-inflammatory [3], antifungal [4], diuretic [5]. Ethanol extract from Z. montana leaf possesses anti-nociceptive [6] and anti-inflammatory [7] activities and flavanones showed cytotoxicity against human NCI-ADR/RES and K562 cell lines [8].…”