Diuretic activity of leaves of<i>Plectranthus amboinicus</i>(Lour) Spreng in male albino rats

Patel, Rohit B.; Mahobia, Naveen K.; Gendle, Ravindra; Kaushik, Basant; Singh, Sudarshan

doi:10.4103/0974-8490.62956

Cited by 31 publications

(17 citation statements)

References 8 publications

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“…2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.…”

Section: Introductionmentioning

confidence: 77%

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Ávila¹,

Pinto²,

Sousa³

et al. 2016

J. Braz. Chem. Soc.

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Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains. Keywords: Plectranthus ornatus, diterpenes, ent-clerodanes, bacteriostatic IntroductionThe genus Plectranthus L'Her (Lamiaceae, subfamily Nepetoideae, tribe Ocimeae, subtribe Plectranthinae) comprises approximately 300 species largely distributed over the African, Asian and Australian continents. 1 Plectranthus is a large genus well known by its diversity of ethnobotanical uses, being especially indicated to treat digestive disorders, skin diseases, infections and respiratory problems. 2 In general, are rich source of essential oils, terpenoids and phenol compounds. 3 Pharmacological properties such as anti-inflammatory, 4 antioxidant, 5 antimicrobial, 6 anti-tumoral 7 and diuretic 8 have been demonstrated for several isolated compounds from Plectranthus, corroborating with its larger medicinal uses.Plectranthus ornatus Codd (syn. Coleus comosus Hochst. ex Gurke) is a perennial and aromatic herb, widespread around the new world. 9 In the northeast of Brazil, P. ornatus, popularly known as "malva santa" or "boldo miúdo", is cultivated as a very important medicinal plant, indicated as analgesic and particularly to treat gastric disorders. 10 Several antimicrobial labdanes, ent-clerodanes, and halimane-type diterpenoids have been previously isolated from P. ornatus. 11 As part of a multidisciplinary program, where the efforts are devoted to study medicinal plants or congeners, in order to unveil their pharmacological or biological properties, herein we describe the isolation and characterization of five new diterpenes derivatives together with six known compounds from the aerial parts of cultivated specimens of P. ornatus, as well as the results of pharmacological and biological assays with the isolated secondary metabolites (Figure 1). Ávila et al. 1015 Vol. 28, No. 6, 2017 Experimental General experimental proceduresOptical rotations were measured on a PerkinElmer 341 digital polarimeter. Infrared (IR) spectra were obtained on a PerkinElmer FT-IR spectrum 1000 spectrometer. Accurate mass spectra were acquired on a liquid chromatography-mass spectrometry ion-trap and time-of-flight (LCMS-IT-TOF, Shimadzu) spectrometer. Nuclear magnetic resonance (NMR) spectra were performed either on Bruker DPX-300 or DRX-500 spectrometers. Open column chromatography (CC) were carried out wit...

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Section: Introductionmentioning

confidence: 77%

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Ávila¹,

Pinto²,

Sousa³

et al. 2016

J. Braz. Chem. Soc.

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“…This initiative could encourage the improvement of adherence to pharmacological treatment, offering a product with great popular appeal and pharmacological effects complementary to conventional therapies. [25][26][27][28][29][30][31] In this study, it was shown for the first time that prolonged treatment with an ethanol extract obtained from T. majus is able to prevent the evolution of renovascular hypertension in 2K1C rats, showing a significant reno-and cardioprotective effect. According to previous data, the renin-angiotensin system (RAS) played a prominent role in the oxidative stress and renovascular hypertension.…”

Section: Discussionmentioning

confidence: 96%

Protective Cardiorenal Effects Of Tropaeolum majus L. In Rats With Renovascular Hypertension

Gasparotto¹,

Prando²,

Gebara³

et al. 2017

JYP

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Background: Tropaeolum majus L. (Tropaeolaceae) is an important medicinal plant belonging to the Tropaeolaceae family, which has 80 species distributed in South and Central America. In Brazil, it is distributed practically throughout the entire territory and it is popularly known as "capuchinha" . In folk medicine its leaves are widely used for treatment of cardiovascular disorders. Despite consistent data showing some acute effects on renal and cardiovascular system, no study has investigated whether Tropaeolum majus extracts is able to exert cardiorenal protective effects after 30 days of treatment, i.e. in a sustained manner. Objective: Investigate the prolonged cardiorenal protective effects of ethanolic extract obtained from Tropaeolum majus (EETM) in rats with renovascular hypertension. Material and Methods: First, EETM was obtained and chemically characterized. Then, we investigated the possible antihypertensive and diuretics effects, including effects on renal haemodynamics, after prolonged treatment (30 days) with EETM (3, 30 and 300 mg/kg). Finally, we examined whether treatment with EETM may affect the angiotensin-converting enzyme (ACE) and oxidative stress, preventing heart and kidney damage in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats. Results: Prolonged treatment with EETM was able to prevent the evolution of renovascular hypertension in 2K1C rats, inducing important renoprotective effects and reducing systemic blood pressure and cardiac hypertrophy. Moreover, it was also identified that these effects may be directly related to significant ACE inhibitory activity and reduction of oxidative stress. Conclusion: This study has brought new scientific evidence of preclinical efficacy of EETM as a cardiorenal protective agent in rats with renovascular hypertension.

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“…12 All the rats were kept in good experimental condition and deprived of food for 18 hours before the experiments. 5ml/kg of Normal saline (0.9%) was given orally to the rats before administration of drug or extracts.…”

Section: Evaluation Of Diuretic Activitymentioning

confidence: 99%

Study of diuretic activity of aqueous extract of amaranthus spinosus linn on rats

Potllapalli

Jagannath

Pavani

et al. 2016

Int J Basic Clin Pharmacol

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Background: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. Whole plant possesses diuretic property. The aim of the present study is to investigate the diuretic activity of aqueous extract of amaranthus spinosus linn on rats.Methods: The rats were randomly divided into four groups of six animals each and deprived of food for 18 hours before the experiments. Control (Group I) rats were treated with Normal saline (5ml/Kg,) and Standard (Group II) rats were administered furosemide 15mg/Kg, I.P. Group III and IV were treated with Aqueous extract of Amaranthus spinosus Linn (AEAS) 250 and 500 mg/kg in normal saline respectively, The urine was collected after 5 and 24 hours. The urine volume and the total concentration of Na+, K+, and Cl- in the urine were estimated. The data were presented as mean ± standard deviation and analyzed using one-way analysis of variance and Student's "t"-test. P <0.05 was considered statistically significant. Conventional windows software was used for statistical analysis.Results: Urine analysis showed that Na+, K+, and Cl- levels were significantly (p<0.05) increased with AEAS 250 and 500 mg/kg as rats treated with furosemide 15mg/kg. Urine volume is significantly (p<0.05) increased in rats treated with drugs (AEAS 500 mg/kg and furosemide 15mg/kg) compared to normal saline 25ml/Kg, treated rats at 5 and 24 hours.Conclusions: These data suggest that AEAS has produced notable diuretic effect which appeared to be comparable to that produced by the standard diuretic furosemide.

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Diuretic activity of leaves ofPlectranthus amboinicus(Lour) Spreng in male albino rats

Cited by 31 publications

References 8 publications

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd

Protective Cardiorenal Effects Of Tropaeolum majus L. In Rats With Renovascular Hypertension

Study of diuretic activity of aqueous extract of amaranthus spinosus linn on rats

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