Diuretic and natriuretic effects of chromatographically purified fraction of garlic (Allium sativum)

Pantoja, C.; Norris, Beryl; Contreras, Cecilia

doi:10.1016/0378-8741(96)01396-7

Cited by 20 publications

(13 citation statements)

References 11 publications

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“…Its main active is allicin, which is responsible for its characteristic smell and has been used for its anti-bacterial properties (Wright et al, 2005). Allium sativum is reputed to offer protection against strokes, coronary thrombosis, atherosclerosis and platelet aggregation, and work as an anti-hypertensive, anti-hyperglycaemic and anti-hyperlipidemic agent (Sharafatullah et al, 1986;Ribeiro et al, 1988;Pantoja et al, 1991Pantoja et al, , 1996Pantoja et al, , 2000Grover et al, 2002). In traditional medicine, it is administered as a diuretic Ribeiro et al (1988) Alliaceae Allium sativum L. Garlic N (anti-hypertensive) Bulb Pantoja et al (1991Pantoja et al ( , 1996Pantoja et al ( , 2000, Ribeiro et al (1988), Sharafatullah et al (1986) Amaranthaceae…”

Section: Alliaceaementioning

confidence: 98%

Herbal medicines as diuretics: A review of the scientific evidence

Wright

Van-Buren

Kroner

et al. 2007

Journal of Ethnopharmacology

240

122

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Section: Alliaceaementioning

confidence: 98%

Herbal medicines as diuretics: A review of the scientific evidence

Wright

Van-Buren

Kroner

et al. 2007

Journal of Ethnopharmacology

240

122

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“…17 The hypotensive effects of garlic constituents may also be explained in part by a significant biphasic diuretic and natriuretic response and by an inhibitory dose-dependent effect on the kidney Na, K-ATPase. [29][30][31] Finally, aqueous garlic extract, as well as allicin and ajoene, can open potassium ion channels, causing membrane hyperpolarization that closes about 20% of the L-type Ca 2+ channels, the consequence of which is vasodilatation. 32,33 It is necessary to note that in our study, Allicor, but not Kwai, induced a statistically significant decrease in DBP.…”

Section: Discussionmentioning

confidence: 99%

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

et al. 2009

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Numerous clinical investigations that have focused on the hypotensive effects of garlic-based preparations have led to controversial results that may be partially because of differences in the composition of the preparations and in the biological responses they induce. It is possible that garlic powder tablets with a prolonged mode of action could induce more potent biological effects. In this double-blind, placebo-controlled trial with an active control arm, the hypotensive action of time-released garlic powder tablets (Allicor) was compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension. After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n¼30) or to placebo (n¼20) daily for 8 weeks. In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n¼18) or 900 mg Kwai daily (n¼16). Allicor treatment (600 mg daily) resulted in a reduction of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively. Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit. Treatment with Kwai resulted in the same decrease in systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as that seen with Allicor, but no decrease in diastolic blood pressure was observed with Kwai. Different effects of Allicor and Kwai on diastolic blood pressure may be because of the prolonged action of Allicor, which allows better bioavailability of the vasoactive constituents of garlic powder. The results of this study show that time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements.

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“…L'activité antihypertensive de quelques plantes a également été prouvée expérimentalement. C'est le cas de l'ail (Allium sativum) (Malik et Siddiqui, 1981;Pantoja et al, , 1996Andrianova et al, 2002), de l'arbousier (Arbutus unedo) (Fitzpatrick et al, 1993;Abdalla et al, 1994), du Romarin (Rosmarinus officinalis) (Aqel, 1991), de la nigelle cultivée (Nigella sativa) (Labhal et al, 1994) …”

Section: Introductionunclassified

Étude ethnobotanique des plantes médicinales utilisées dans le traitement du diabète, et des maladies cardiaques dans la région d’Izarène (Nord du Maroc)

Orch¹,

Douira²,

Zidane³

2015

J. App. Bioscience.

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RÉSUMÉObjectif : Dans le but de contribuer à une meilleure connaissance des plantes médicinales utilisées dans le traitement du diabète et de l'hypertension artérielle, auprès de la population riveraine de la forêt d'Izarène. Méthodologie et résultats : Des enquêtes ethnobotaniques ont été réalisées à l'aide de 264 fiches questionnaires dans la région étudiée. Les résultats obtenus ont permis d'inventorier 57 espèces de plantes médicinales appartenant à 30 familles et réparties en 52 genres. Parmi ces espèces, 40 sont traditionnellement utilisées contre le diabète et 30 contre l'hypertension artérielle. Parmi les 40 espèces utilisées dans le traitement du diabète, 13 sont également employées pour traiter l'hypertension artérielle. Il s'agit de : Ajuga iva (Ivette musquée), Centaurium Erythraea (Petite centaurée), Origanum compactum (Origan), Rosmarinus officinalis (Romarin), Nigella sativa (Nigelle cultivée), Pistacia lentiscus (Lentisque), Tetraclinis articulata (Thuya), Arbutus unedo (Arbousier), Trigonella foenum-graecum (Fenugrec), Lavandula dentata (Lavande dentée), Salvia officinalis (Calamenthe vulgare), Eugenia caryophyllata (Giroflier), et Olea europaea (Olivier). Les feuilles sont les organes les plus utilisés. La décoction est le mode de préparation dominant et l'administration se fait majoritairement par voie orale. Parmi les 57 espèces médicinales utilisées par la population riveraine, 18 espèces (soit 31.57%) spontanées sont collectées de la forêt d'Izarène. La surexploitation menace certaines espèces peu abondantes, comme Origanum compactum, Centaurium Erythraea et Salvia verbenaca (Sauge à feuilles de verveine) de disparition de la forêt d'Izarène. D'où l'intérêt d'adopter une approche de gestion durable pour assurer la conservation et la préservation de ces espèces. and 30 families. Of these, 40 are traditionally used against diabetes and 30 against hypertension. Of the 40 species used in the treatment of diabetes, 13 are also used to treat high blood pressure. These are: Ajuga iva (Ivette musky), Centaurium erythraea (Centaury), Origanum compactum (Oregano), Rosmarinus officinalis (Rosemary), Nigella sativa (Fennel Flower), Pistacia lentiscus (Mastic), Tetraclinis articulata (Thuja), Arbutus unedo (Arbutus), Trigonella foenum-graecum (Fenugreek), Lavandula dentata (Toothed Lavender), Salvia officinalis (Calamenthe vulgare), Eugenia caryophyllata (Clove) and Olea europaea (The Olive Tree). The leaves are the most used organs. The decoction is the dominant mode of preparation and administration is done mostly orally. Of the 57 medicinal species used by the local population, 18 species (31.57%) spontaneous is collected from the forest of Izarène. Overexploitation threatens some scarce species such as, Origanum compactum, Centaurium Erythraea, and Salvia verbenaca (sage verbena leaves) disappearance of the Izarène forest. Hence the need to adopt a sustainable management approach for the conservation and preservation of these species. L'hypertension artérielle (HTA) est l'un des principaux détermina...

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Diuretic and natriuretic effects of chromatographically purified fraction of garlic (Allium sativum)

Cited by 20 publications

References 11 publications

Herbal medicines as diuretics: A review of the scientific evidence

Herbal medicines as diuretics: A review of the scientific evidence

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension

Étude ethnobotanique des plantes médicinales utilisées dans le traitement du diabète, et des maladies cardiaques dans la région d’Izarène (Nord du Maroc)

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