Diuretic effect of chloroform seed extract of Moringa oleifera (Linn.) in Wistar rats

Kumar, H.S.Anil; Jafrin, A Lourdu

doi:10.18203/2319-2003.ijbcp20164124

Cited by 2 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation, in conjunction with the earlier discussed effect of 1000 mg kgG 1 MOLP on the animals' feed intake, body weight changes and ALT activity, further suggest a potential negative effect of intake of high doses of the plant's leaves. However, the observed general positive effect of the plant leaves on kidney function substantiates the reported diuretic potential of the plant in ethnomedical practice 15,22 . Table 2 also showed that there were non-significant (p>0.05) changes in plasma chloride, sodium and potassium concentrations of the MOLP fed animal groups in comparison with the control group.…”

Section: Resultssupporting

confidence: 73%

“…Platelets, also called thrombocytes are the components of blood involved in blood clot formation with the clotting factors. Excessive elevation in blood platelet count could be detrimental to the normal liquidity and flow of blood 22 . The later comment further buttresses the need for caution in the intake of high doses of M. oleifera based diets.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Igwe¹,

Ezerioha²,

Iheme³

et al. 2022

J. of Applied Sciences

View full text Add to dashboard Cite

Background and Objective: Moringa oleifera is a widely acclaimed ʻmiracle plantʼ whose medicinal and nutritional importance require documentation. The effect of Moringa oleifera leaf powder (MOLP) intake on haematologic, hepatic and renal function indices was studied using standard methods. Materials and Methods: Twenty-four Albino rabbits, weighing 0.9-1.8 kg, were distributed into group I animals fed the control diet and groups II-IV fed 500, 750 and 1000 mg kgG 1 b.wt., of MOLP, respectively for 28 days. Feed intake and body weights of the animals were measured daily. Results: Groups fed 500 and 750 mg kgG 1 of MOLP consumed more of the feed and showed a non-significant (p>0.05) but a more progressive increase in mean body weights. Intake of MOLP did not significantly (p>0.05) alter most of the biochemical and hematologic indices studied but serum total protein, albumin and haemoglobin concentrations increased significantly (p<0.05), while red blood cell indices increased non-significantly (p>0.05) with the increase in MOLP dosage. Generally, 500 and 750 mg kgG 1 MOLP diets gave better positive indices than 1000 mg kgG 1 MOLP. Conclusion: Apparently, MOLP intake has no harmful effects on the liver, kidney and blood parameters of animals but may enhance the building capacity, repair and maintenance of body tissues. However, the study calls for caution in the use of very high doses.

show abstract

Section: Resultssupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Igwe¹,

Ezerioha²,

Iheme³

et al. 2022

J. of Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Previously, the Moringa oleifera plant's roots, leaves, flowers and seeds have been reported in literature as diuretic and antihypertensive by some scientists (Gadge 2006;Fernandes et al 2016;Kumar et al 2016). But no report could be retrieved about the causative constituents responsible for such activities.…”

Section: Discussionmentioning

confidence: 99%

“…In cultivation, it is often cut back annually to 1-2 m (3-6 feet) and allowed to re-grow so the pods and leaves remain within arm's reach (Zhigila 2014). Moringa roots, leaves, flowers, gum and seeds have been found to possess diuretic activity and such diuretic components are likely to play a complementary role in the overall blood pressure lowering effect of this plant (Morton 1991;Caceres et al 1992;Kumar et al 2016). From literature review it has been found that different parts of this plant have many medicinal importance and some parts such as seeds and leaves or barks have already been investigated by some earlier researchers except pods (the most edible part of its fruit).…”

mentioning

confidence: 99%

Diuretic and Laxative Activities of Moringa Oleifera Seeds and Pods in Mice

et al. 2022

View full text Add to dashboard Cite

Moringa oleifera (Family- Moringaceae) is a well-known vegetable for its health benefits for thousands of years having diverse nutritional bioactive constituents. Phytochemical analysis of ethanolic extract of this plant indicated the presence of carbohydrate, reducing sugar, combined reducing sugar, glycosides, tannins (absent in seeds), alkaloids, flavonoids, saponins and steroids. In diuretic activity test, the extract showed a significant (p<0.001) effect at the dose of 200 & 400 mg/kg body weight in production of total urine volume in comparison with standard drug furosemide (5 mg/kg). Upon electrolyte analysis of excreted urine, the extract was found to increase Na+, K+, Clexcretion and may act as loop diuretics. The pods and seeds extract showed significant (p<0.01) laxative effects in mice in terms of stool production with soft consistency at the dose of 200 & 400 mg/kg in comparison with standard drug bisacodyl (10 mg/kg). The most edible part of this plant is pods which showed better diuretic and laxative effects than seeds. So, the pods may be a good source of bioactive constituents which may be used as parent compound(s) for discovering better diuretic or laxative drugs.

show abstract

Diuretic effect of chloroform seed extract of Moringa oleifera (Linn.) in Wistar rats

Cited by 2 publications

References 1 publication

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Intake of Moringa oleifera Leaf Powder Positive Biochemical and Haematologic Effects in Albino Rabbits

Diuretic and Laxative Activities of Moringa Oleifera Seeds and Pods in Mice

Contact Info

Product

Resources

About