Diuretic-induced dyselectrolytemia and its clinical implications

Jha, Vijoy Kumar; Padmaprakash, K V; Pandey, R.P.

doi:10.4103/cmi.cmi_22_18

Cited by 1 publication

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypokalemia occurs when serum potassium levels under 3.6 mmol/l-weakness, fatigue, and muscle twitching present in hypokalemia. 6 In our study hypokalemia was significantly higher in diuretic group than non-diuretic group. Weakness was complained by 10 out of 14 patients with hypokalemia.…”

Section: Discussionsupporting

confidence: 48%

“…Similar observation has been made in previous studies. 6 Previous studies have reported hyponatremia between 13 and 22%. 6,10 However these studies were related to thiazide related electrolyte disorders.…”

Section: Discussionmentioning

confidence: 98%

“…6 Previous studies have reported hyponatremia between 13 and 22%. 6,10 However these studies were related to thiazide related electrolyte disorders. Indian study from North India reported 27%.…”

Section: Discussionmentioning

confidence: 98%

“…Hyperkalemia is an important complication of the potassium-sparing agents, especially in patients with an underlying tendency for hyperkalemia. [4][5][6] Thiazide-induced hypokalemia is associated with increased blood glucose, and treatment of thiazide-induced hypokalemia may reverse glucose intolerance and possibly prevent diabetes. 4 Thiazide use has been shown to be a clear risk factor for hyponatremia and hypokalemia.…”

mentioning

confidence: 99%

“…The increase in calcium delivery to the lumen of the distal nephron inhibits Na reabsorption and diminishes K secretion. 6 Potassium-sparing diuretics such as spironolactone, amiloride, and triamterene have the potential to cause hyperkalemia. Hyperkalemia is associated with an increased risk of death, and this is partly explicable by hyperkalemia-induced cardiac arrhythmia.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Effect of diuretics on sodium, potassium and chloride levels- a cross sectional study

Patel

Parikh²,

Vaghela³

2022

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Diuretics are one of the widely used class of drugs used in various cardiovascular and other disorders. However, they can cause various metabolic adverse effects, electrolyte imbalance being among important changes.Methods: A cross sectional study was conducted in which patients diagnosed with hypertension for at least one month were included. Over a period of 6 months patients were enrolled irrespective of whether they were taking diuretics or not. Demographic details, drug therapy and electrolyte levels were recorded in a proforma. Data was analyzed for difference in serum electrolyte levels between diuretic and nondiuretic groups as well as between different diuretic groups.Results: Out of total 177 participants, 71 were on diuretic therapy. There was significant difference in mean serum sodium (S. Na), potassium (S. K) and chlorine (S. Cl) levels between diuretic and nondiuretic groups (P<0.05). Hyponatremia, hypokalemia and hyperkalemia were observed. Thiazide diuretic group showed significantly greater hyponatremia compared to other diuretics (P=0.028). Hyperkalemia was observed in participants receiving K sparing diuretic or combination of loop and K sparing diuretics. Old age and number of comorbidities showed negative association with S. Na. Females had significantly more hyponatremia than male participants.Conclusions: The study confirms that diuretics cause various abnormalities in electrolytes namely Na and K levels. Old age, comorbidities and female sex are risk factors for hyponatremia.

show abstract

Section: Discussionsupporting

confidence: 48%