Diuretic Renal Scintigraphy in Normal Dogs

Hecht, Silke; Daniel, Gregory B.; Mitchell, Sally K.

doi:10.1111/j.1740-8261.2006.00194.x

Cited by 15 publications

(17 citation statements)

References 45 publications

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“…Diuretic sonography can also help in confirming outflow obstruction in humans 27 . While the use of diuretics has been described with scintigraphy, 28 it has not been described with ultrasonography in small animals.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Renal Pelvic Dilatation on Ultrasound in Dogs and Cats

d’Anjou

Bédard

Dunn

2010

Vet Radiology Ultrasound

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Renal pelvic dilatation is often recognized sonographically in dogs and cats, but ranges of measurements expected with different urologic conditions remain unknown. Ultrasound images of 81 dogs and 66 cats with renal pelvic dilatation were reviewed, and six groups were formed based on medical records: (I) clinically normal renal function, and (II) clinically normal renal function with diuresis; (III) pyelonephritis; (IV) noninfectious renal insufficiency; (V) outflow obstruction; (VI) miscellaneous nonobstructive anomalies. Medians for maximal pelvic width (range) for group I was 2.0 mm (1.0-3.8) in 11 dogs, and 1.6 mm (0.8-3.2) in 10 cats; for group II, 2.5 mm (1.3-3.6) in 15 dogs, and 2.3 mm (1.1-3.4) in 16 cats; for group III, 3.6 mm (1.9-12.0) in nine dogs, and 4.0 mm (1.7-12.4) in seven cats; for group IV, 3.1 mm (0.5-10.8) in 33 dogs, and 2.8 mm (1.2-7.3) in 13 cats; for group V, 15.1 mm (5.1-76.2) in six dogs, and 6.8 mm (1.2-39.1) in 17 cats; and for group VI, 3.8 mm (1.2-7.6) in seven dogs, and 3.0 mm (1.3-7.5) in three cats. Pelvic width in group I was lower than in groups III-V (P ¼ 0.0001), but did not significantly differ from group II. Pelvic width !13 mm always indicated obstruction. While the proportion of bilateral pelvic dilatation was not different among groups, the difference in pelvic width (maximal-minimal) was greater in group V vs. groups I, II, and IV (P ¼ 0.0009). These results confirm that renal pelvic dilatation can be detected sonographically in dogs and cats with clinically normal renal function, and that it increases with renal insufficiency, pyelonephritis, or outflow obstruction. Nevertheless, renal pelvic width varies substantially within groups and should be interpreted with caution. r

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Renal Pelvic Dilatation on Ultrasound in Dogs and Cats

d’Anjou

Bédard

Dunn

2010

Vet Radiology Ultrasound

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“…Renal excretion was measured from the down slope of the renogram curves, when egress from the kidney visibly exceeds continuing accumulation of radiopharmaceutical in the renal parenchyma. To standardize the slope of the excretion phase, all renogram curves were normalized to a peak value of 10,000 as previously described 24 …”

Section: Methodsmentioning

confidence: 99%

“…Diuretic renal scintigraphy has been assessed in normal dogs and there was a significant difference in excretion half‐life ( T 1/2 ) of radiopharmaceutical between dogs given a diuretic (median T 1/2 : 4.16 min) and control dogs (median T 1/2 : 10.25 min) 24 . The time–activity curve (TAC) in the diuretic group was characterized by a steep drop after administration of furosemide indicative of rapid excretion of the radiopharmaceutical; this has been termed the classic nonobstructive pattern in human medicine 25 .…”

Section: Introductionmentioning

confidence: 99%

Diuretic Renal Scintigraphy in Normal Cats

Hecht

Lane

Daniel

et al. 2008

Vet Radiology Ultrasound

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The purpose of this study was to develop a protocol for diuretic renal scintigraphy (renography) in cats and describe normal findings. 99mTc-DTPA renal scintigraphy was performed twice in 10 healthy cats. Furosemide or saline were injected 4.5 min after radiopharmaceutical administration for the diuretic or control scan, respectively. A dynamic acquisition was performed for 8 min. The following parameters were evaluated: (1) global and individual glomerular filtration rate (GFR); (2) shape of the time-activity curve (TAC); (3) time of peak (TOP); (4) individual kidney excretion half-time (T1/2) of the radiopharmaceutical; (5) percentage of maximum activity measured at the end of the study. Global GFR in the control studies (2.79 +/- 0.83 ml/min/kg, mean +/- SD) did not differ significantly from the diuretic scans (2.34 +/- 0.51 ml/min/kg). The shape of most (16/ 20) TAC of diuretic renograms was similar to those of control renograms. The TOP of the diuretic renogram curves was 3.06 +/- 0.58 min, and did not differ from that of the control scans (3.01 +/- 0.61 min). T1/2 of the diuretic renograms was significantly shorter (5.15 +/- 0.83 min) than that of the control renograms (6.31 +/- 1.50 min). A significantly lower percentage of maximum activity was present at the end of the study in diuretic renograms (median: 47.25%; range: 33.60-59.60%) compared with control renograms (63.40%; 30.00-69.40%). Diuretic renal scintigraphy is a noninvasive and fast procedure to perform in cats. The applicability of this technique needs to be investigated in patients with significantly impaired renal function and obstructive uropathies.

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“…It is also used in animal studies. For instance, this technique has been exploited for studying the kidneys and its diseases in dogs [11] and in cats [12].…”

Section: Discussionmentioning

confidence: 99%

“…This is in agreement with the results for cat in the present study. The present study revealed that 99m Tc pharmaceutical can be used in cats as well as humans [3] and the other animals [11,12]. In addition, renal scintigraphy of cats can be performed easily and their GFR can be measured [10,16].…”

Section: Discussionmentioning

confidence: 99%