Diuretic Therapy in Heart Failure – Current Approaches

Casu, Gavino; Merella, Pierluigi

doi:10.15420/ecr.2015.10.01.42

Cited by 72 publications

(53 citation statements)

References 49 publications

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“…However, concerning mechanism and indication, loop diuretics function by enhancing salt and water excretion and are clinically used to maintain euvolaemia or prevent volume expansion. 26 In other words, it makes no significant contribution to alteration of dry body weight, which is used for BMI determination and obesity evaluation. Therefore, despite the above findings, loop diuretics were excluded from our further analysis.…”

Section: Body Mass Index and Beta-blocker Usementioning

confidence: 99%

Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis

et al. 2020

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Studies of Caucasian populations have shown that beta-blockers may exacerbate weight gain, a risk factor for many chronic diseases. Still, beta-blockers are the most prescribed antihypertensives in the Chinese population in Hong Kong. We aimed to explore the association between beta-blocker use, hypertension, and weight status of this population. Methods: A post-hoc analysis regarding body mass index (BMI) and the use of beta-blockers was performed based on the medication profile of community-dwelling older adults. Participants' BMI, hypertension diagnosis, name, dose, frequency, route of administration of beta-blockers, and other drugs that may alter body weight were recorded. Results: Of 1053 Chinese individuals aged ≥65 years (mean age 76.9±7.2 years, 80% female) from 32 elderly centres in Hong Kong, 18% (185/1053) of them consumed beta-blockers. That group also had a significantly larger proportion of obese individuals (45.9% vs 32.1%, P=0.002). After adjusting for other weight-altering drugs, beta-blockers remained a significant predictor of overweight and obesity (P=0.001). As the hypertensive population had significantly higher BMI than the normotensive population (24.3±3.6 vs 22.9±3.5, P<0.001), a subanalysis on those with hypertension diagnosis

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Section: Body Mass Index and Beta-blocker Usementioning

confidence: 99%

Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis

et al. 2020

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“…Clinical data regarding the diuretic effect is controversial because the plasma volume contraction has been shown to level off at~12 weeks of treatment (26). In addition, diuretics have not demonstrated morbidity and mortality benefit in patients with HF, leading researchers to believe the benefit extends beyond natriuresis (27).…”

Section: Sglt2 Inhibitorsmentioning

confidence: 99%

Optimizing Management of Type 2 Diabetes and Its Complications in Patients With Heart Failure

et al. 2021

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“…There is also evidence that epigenetic regulations of NKCC1 may play a role in its effects on the vascular tone [ 97 ]. A study by Lee et al found that the expression of NKCC1 mRNA and protein levels in the aorta and heart tissues are higher in spontaneous hypertensive rats (SHR) than in normotensive rats [ 51 ].…”

Section: Role Of Nkcc In Cardiovascular Diseasementioning

confidence: 99%

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

Azlan

Zhang

2020

Cells

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The SLC12 family of cation-chloride-cotransporters (CCCs) is comprised of potassium chloride cotransporters (KCCs), which mediate Cl− extrusion and sodium-potassium chloride cotransporters (N[K]CCs), which mediate Cl− loading. The CCCs play vital roles in cell volume regulation and ion homeostasis. The functions of CCCs influence a variety of physiological processes, many of which overlap with the pathophysiology of cardiovascular disease. Although not all of the cotransporters have been linked to Mendelian genetic disorders, recent studies have provided new insights into their functional role in vascular and renal cells in addition to their contribution to cardiovascular diseases. Particularly, an imbalance in potassium levels promotes the pathogenesis of atherosclerosis and disturbances in sodium homeostasis are one of the causes of hypertension. Recent findings suggest hypothalamic signaling as a key signaling pathway in the pathophysiology of hypertension. In this review, we summarize and discuss the role of CCCs in cardiovascular disease with particular emphasis on knowledge gained in recent years on NKCCs and KCCs.

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Diuretic Therapy in Heart Failure – Current Approaches

Cited by 72 publications

References 49 publications

Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis

Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis

Optimizing Management of Type 2 Diabetes and Its Complications in Patients With Heart Failure

Role of the Cation-Chloride-Cotransporters in Cardiovascular Disease

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