Diurnal and seasonal variation in psoriasis symptoms

Ferguson, Felicity J.; Lada, Georgia; Hunter, Hamish J.A.; Bundy, Christine; Henry, Alasdair L.; Griffiths, C.E.M.; Kleyn, C. Elise

doi:10.1111/jdv.16791

Cited by 27 publications

(21 citation statements)

References 10 publications

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“…A seasonal pattern has been proposed in a variety of skin disorders, including alopecia areata, psoriasis, acne, and atopic dermatitis. [5][6][7][8][9][10][11][12] Our findings revealed the lowest prevalence of SD during the summer in all age groups and for both sexes. This seasonal pattern may be related to increased ultraviolet radiation (UVR) exposure, higher levels of air humidity, and changes to the skin microbiome during warmer months.…”

Section: Discussionsupporting

confidence: 43%

The differences of demographic features and seasonal variation in Seborrheic Dermatitis Between Adults And Children: A Cross-Sectional, Single-Center, Hospital-Based Study

Uzunçakmak¹

2021

South Clin Ist Euras

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Objective: Seborrheic dermatitis (SD) is a common chronic inflammatory skin disorder characterized by erythematous papulosquamous lesions in body regions that are rich in sebaceous glands, particularly the scalp, face, and intertriginous areas. Seasonal variation has been reported in different skin diseases; however, the results have been contradictory. The aim of this research was to analyze the demographic characteristics of patients with SD and to examine the impact of seasonality.Methods: Patients who were diagnosed with SD at an outpatient dermatology clinic between June 1, 2015 and June 1, 2020 were included in this retrospective, cross-sectional, single-center, hospital-based study. Both pediatric and adult dermatology outpatient cases were evaluated.Results: A total of 2656 patients with SD presented at the outpatient clinic during the study period. The mean age was 31.99±15.88 years (range: 0-87 years). Among these patients, 1540 (58%) were males and 1116 (42%) were females. SD was most common among those aged 20-30 years (29.9%). The mean age was 29.51±15.43 years in the female patients and 33.80±15.96 in males. Evaluation according to season revealed that 817 (31%) patients presented during the winter months, 615 patients in spring (23%), 452 in summer (17%), and 772 (29%) in the autumn. Conclusion:SD is a common, multifactorial skin disease. This study evaluated a wide patient profile and it was observed that middle-aged adults and men were the most affected. Patients presented most frequently during the cold weather season. Although the data obtained from this study are similar to others in the existing literature, these findings provide a new contribution to the epidemiological data of Turkey. Prospectively designed, population-based studies that evaluate potential triggering factors will help to explain the full etiology and seasonal incidence more clearly.

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Section: Discussionsupporting

confidence: 43%

The differences of demographic features and seasonal variation in Seborrheic Dermatitis Between Adults And Children: A Cross-Sectional, Single-Center, Hospital-Based Study

Uzunçakmak¹

2021

South Clin Ist Euras

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“…In humans, disruption of the circadian clock through night shift work is associated with psoriasis [116,117]. The symptoms of psoriasis also show a diurnal pattern, with more than 70% of patients reporting more severe itch in the evening or at night [118]. With most of the itch occurring at night, AD and psoriasis symptoms compromise sleep quality [119], which in turn disrupts circadian rhythms and increases severity of the disease.…”

Section: Inflammatory Skin Diseasesmentioning

confidence: 99%

The circadian clock and diseases of the skin

et al. 2021

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Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light-dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the core clock network and fundamental physiological processes in skin such as homeostasis, regeneration, and immune-and stress responses. We illustrate the effect of feeding time on the skin circadian clock and skin functions, a previously overlooked area of research. We then discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing. Finally, we highlight the promise of circadian medicine for skin disease prevention and management.

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“…In psoriasis, daily as well as seasonal variations in its symptoms has reported. In this cross-sectional online survey study, the authors showed that pruritus and flare-ups in psoriasis fluctuate daily, the worst in the evening followed by nighttime [46]. Recently, increasing numbers of studies in mouse models have been conducted to investigate the mechanisms underlying circadian regulation of the skin homeostasis.…”

Section: Circadian Regulation In Psoriasismentioning

confidence: 99%

Skin and immune cells crosstalk via circadian regulations

Orihara

2021

Explor Immunol

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Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over recent years, we have gained a better understanding of the molecular mechanisms that control biological clocks and circadian rhythms. Circadian rhythms maintain homeostasis by providing day and night information to various physiological functions of our body. However, excessively high immune system activity can lead to a risk of developing autoimmune or allergic diseases. Recently, increasing numbers of studies with human and mouse models have been conducted to investigate the mechanisms underlying circadian regulation of the skin homeostasis. In this review, circadian regulation in the skin will be discussed from different points of view. Skin is referred as the largest organ of the body and is directly exposed to the external environment, including large changes in diurnal temperature, light, and pathogens. Immune cells as well as skin cells are the ones protecting us from these stimulants. Associations of the circadian system and these cells have been revealed in many ways, however, the specific roles of the peripheral clocks in these cells remain unknown. Circadian regulation in the skin diseases is discussed specifically in atopic dermatitis and other skin allergic symptoms as well as psoriasis.

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Diurnal and seasonal variation in psoriasis symptoms

Cited by 27 publications

References 10 publications

The differences of demographic features and seasonal variation in Seborrheic Dermatitis Between Adults And Children: A Cross-Sectional, Single-Center, Hospital-Based Study

The differences of demographic features and seasonal variation in Seborrheic Dermatitis Between Adults And Children: A Cross-Sectional, Single-Center, Hospital-Based Study

The circadian clock and diseases of the skin

Skin and immune cells crosstalk via circadian regulations

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