Diurnal blood and urine glucose and acetone bodies in labile juvenile diabetics on one ? and two-injection insulin therapy

Åkerblom, Hans K.; Hiekkala, H

doi:10.1007/bf00421440

Cited by 21 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46], In spite of the fact that the turnover of these plasma constituents is a matter of minutes rather than hours and their concentrations are profoundly and rapidly influenced by dietary manipulation, most studies on these interrelations have dealt only with fasting lipid values. Diurnal changes have attracted major attention only in diabetics where patterns of blood sugar, insulin and occasionally FFA and triglyceride levels have been reported by a number of authors [1,7,22,35,37,41,52]. Experiments in normal subjects were few [4, 18.…”

mentioning

confidence: 99%

Diurnal Patterns of Blood Sugar, Plasma Insulin, Free Fatty Acid and Triglyceride Levels in Normal Subjects and in Patients with Type IV Hyperlipoproteinemia and the Effect of Meal Frequency

Schlierf

Raetzer

1972

Ann Nutr Metab

View full text Add to dashboard Cite

Diurnal patterns of plasma triglycerides, free fatty acids, blood sugar and insulin were studied in 6 normal subjects and in 6 patients with the type IV hyperlipoproteinemia in order to assess the effect of a formula diet of balanced composition(19% protein, 37% fat, 44% carbohydrate) and of frequency of meal intake (3 versus 6 meals). In addition, the endogenous component of alimentary lipemia was estimated for the 24-hour period. The results demonstrate, that all-day levels of nutrients and insulin are similar with both meal patterns and that, regardless of feeding frequency, a considerable portion of ‘alimentary lipemia’ is contributed by pre-beta lipoprotein triglycerides.

show abstract

mentioning

confidence: 99%

Diurnal Patterns of Blood Sugar, Plasma Insulin, Free Fatty Acid and Triglyceride Levels in Normal Subjects and in Patients with Type IV Hyperlipoproteinemia and the Effect of Meal Frequency

Schlierf

Raetzer

1972

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…As a guide to optimal control of the diabetic patient the integrated analysis of blood glucose and blood 3-HB and/or AcAc is preferable to that of blood glucose alone (7,22,26,27). The ketosis may be monitored in several ways, as the present study has shown.…”

Section: Discussionmentioning

confidence: 82%

Clinical Value of Ketone Body Determinations in Brittle Diabetes

Rooth

1972

Journal of Internal Medicine

View full text Add to dashboard Cite

The first part of this study is a clinical investigation on the value of concomitant measurements of blood glucose and the ketone bodies for the improvement of control in 35 patients with brittle diabetes. Three groups are identified: 1) The keto resistant patient in whom only the blood glucose measurements are of value. 2) A group in whom about equally valuable information is obtained from blood glucose and the ketosis. 3) The Poulsen‐Somogyi reactors in whom both blood glucose and ketonaemia should be analysed. The level of ketosis may be judged from blood 3‐hydroxybutyrate (3‐HB) and acetoacetate (AcAc) or from breath acetone, although the latter does not change as fast as the metabolized 3‐HB and AcAc. The changes in the urinary concentrations of 3‐HB and AcAc are almost as rapid as those in the blood, and after insulin a decrease in these urinary concentrations is often seen before the blood glucose begins to decrease. The second part of the study shows the positive correlations between the increase in blood glucose above 200 mg/100 ml of blood and blood 3‐HB and AcAc and the decrease in the ratio blood 3‐HB/AcAc with decreasing blood glucose. Preliminary data are also given on the decrement of blood 3‐HB and AcAc with time, indicating an initial slower phase and a second faster one. The daily blood lactate changes were greater than expected. Initially they were parallel to the blood 3‐HB and AcAc variations. Once blood glucose concentration also fell the lactate increased a mean of 1.9 mEq/1.

show abstract

“…Ketogenesis is intensified under conditions characterised by the insufficient or inaccessible availability of glucose, and higher acetone levels have also been reported in individuals with diabetes [ 31 ]. In fact, diurnal fluctuations in acetone were initially investigated in connection with the establishment of insulin therapy [ 32 ]. In the present study, the effect on acetone could indicate an effect of vitamin D on the beta-oxidation of fatty acids and thereby the formation and accumulation of ketone bodies.…”

Section: Discussionmentioning

confidence: 99%

The Diurnal Blood Metabolome and Effects of Vitamin D Supplementation: A Randomised Crossover Trial in Postmenopausal Women

Espersen

Correia²,

Rejnmark³

et al. 2022

IJMS

View full text Add to dashboard Cite

A way to maintain an adequate vitamin D status is through supplementation. Demonstration of blood-metabolome rhythmicity of vitamin D3 post-dosing effects is lacking in the pharmaco-metabonomics area. Thus, the overall aim of this study was to investigate the diurnal changes in the blood metabolome and how these are affected by vitamin D3 supplementation. The study was conducted as a crossover study, and the treatment included 200 µg (8000 IU) of vitamin D3 as compared with placebo with a washout period of at least 10 days. The participants were postmenopausal women aged 60–80 years (N = 29) with vitamin D insufficiency (serum 25-hydroxyvitamin D < 50 nmol/L) but otherwise healthy. During the intervention day, blood samples were taken at 0 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, and 24 h, and plasma was analysed by proton nuclear magnetic resonance (NMR) spectroscopy as a metabolomics approach. In general, diurnal effects were identified for the majority of the 20 quantified metabolites, and hierarchical cluster analysis revealed a change in the overall plasma metabolome around 12 AM (6 h after intervention), suggesting that the diurnal rhythm is reflected in two diurnal plasma metabolomes; a morning metabolome (8–12 AM) and an afternoon/evening metabolome (2–8 PM). Overall, the effect of vitamin D supplementation on the blood metabolome was minor, with no effect on the diurnal rhythm. However, a significant effect of the vitamin D supplementation on plasma acetone levels was identified. Collectively, our findings reveal an influence of diurnal rhythm on the plasma metabolome, while vitamin D supplementation appears to have minor influence on fluctuations in the plasma metabolome.

show abstract

Diurnal blood and urine glucose and acetone bodies in labile juvenile diabetics on one ? and two-injection insulin therapy

Cited by 21 publications

References 9 publications

Diurnal Patterns of Blood Sugar, Plasma Insulin, Free Fatty Acid and Triglyceride Levels in Normal Subjects and in Patients with Type IV Hyperlipoproteinemia and the Effect of Meal Frequency

Diurnal Patterns of Blood Sugar, Plasma Insulin, Free Fatty Acid and Triglyceride Levels in Normal Subjects and in Patients with Type IV Hyperlipoproteinemia and the Effect of Meal Frequency

Clinical Value of Ketone Body Determinations in Brittle Diabetes

The Diurnal Blood Metabolome and Effects of Vitamin D Supplementation: A Randomised Crossover Trial in Postmenopausal Women

Contact Info

Product

Resources

About