Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study

Broms, Ulla; Pennanen, Marjaana; Patja, Kristiina; Ollila, Hanna; Korhonen, Tellervo; Kankaanpää, Aino; Haukkala, Ari; Tuulio‐Henriksson, Annamari; Koskenvuo, Markku; Kronholm, Erkki; Laatikainen, Tiina; Peltonen, Markku; Partonen, Timo; Kaprio, Jaakko

doi:10.4172/2155-6105.s2-002

Cited by 24 publications

(25 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cotinine and 3-hydroxycotinine phenotypes were measured from frozen serum samples using liquid chromatography/tandem mass spectrometry (University of Toronto, prof. Rachel Tyndale’s laboratory) for the FinnTwin12, FinnTwin16, and YFS samples, as previously described [ 33 ], and using gas chromatograph-mass spectrometer (at the National Institute for Health and Welfare, Helsinki, Finland) for the FINRISK2007 sample, as previously described [ 34 ]; these assays for NMR were demonstrated to be fully concordant (R 2 = 0.93, P<0.0001) [ 35 ]. Cotinine threshold of ≥10ng/ml was applied to restrict the analyses to regular smokers.…”

Section: Methodsmentioning

confidence: 99%

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

et al. 2015

View full text Add to dashboard Cite

Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy is dependent on the rate of nicotine metabolism. Our objective was to use nicotine metabolite ratio (NMR), an established biomarker of nicotine metabolism rate, in a genome-wide association study (GWAS) to identify novel genetic variants influencing nicotine metabolism. A heritability estimate of 0.81 (95% CI 0.70–0.88) was obtained for NMR using monozygotic and dizygotic twins of the FinnTwin cohort. We performed a GWAS in cotinine-verified current smokers of three Finnish cohorts (FinnTwin, Young Finns Study, FINRISK2007), followed by a meta-analysis of 1518 subjects, and annotated the genome-wide significant SNPs with methylation quantitative loci (meQTL) analyses. We detected association on 19q13 with 719 SNPs exceeding genome-wide significance within a 4.2 Mb region. The strongest evidence for association emerged for CYP2A6 (min p = 5.77E-86, in intron 4), the main metabolic enzyme for nicotine. Other interesting genes with genome-wide significant signals included CYP2B6, CYP2A7, EGLN2, and NUMBL. Conditional analyses revealed three independent signals on 19q13, all located within or in the immediate vicinity of CYP2A6. A genetic risk score constructed using the independent signals showed association with smoking quantity (p = 0.0019) in two independent Finnish samples. Our meQTL results showed that methylation values of 16 CpG sites within the region are affected by genotypes of the genome-wide significant SNPs, and according to causal inference test, for some of the SNPs the effect on NMR is mediated through methylation. To our knowledge, this is the first GWAS on NMR. Our results enclose three independent novel signals on 19q13.2. The detected CYP2A6 variants explain a strikingly large fraction of variance (up to 31%) in NMR in these study samples. Further, we provide evidence for plausible epigenetic mechanisms influencing NMR.

show abstract

Section: Methodsmentioning

confidence: 99%

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Previous studies have revealed that E-types have higher risks for a range of health problems [5] – [10] , they are more prone to worse health habits such as smoking [11] – [14] , greater alcohol use [11] and binge drinking [15] , and dietary intakes that are not only unhealthy [16] but also emotionally-driven [17] . Further, E-types also tend to die younger [18] , but concerning this issue, however, there are currently only limited data (i.e.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Trait of Morningness-Eveningness in Association with Articular and Spinal Diseases in a Population

et al. 2014

View full text Add to dashboard Cite

Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089), as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Finland. Chronotype was assessed based on six items from the original Horne-Östberg Morningness-Eveningness Questionnaire. Information about risk factors and the diagnoses of articular and spinal diseases were based on the self-reported information. Our results suggest that Evening-types have higher odds for articular and spinal diseases as compared with Morning-types, and this risk is heightened especially regarding spinal disease and backache (odds ratios of 1.8 to 2.1, and 1.6 to 1.8, respectively) and remains significant after controlling for the sex, age, education, civil status, physical activity, alcohol use, and smoking, and additionally for the body-mass index, insufficient sleep, or depressive symptoms.

show abstract

“…First, the crude (univariate) association with chronotype was analyzed; second, the model was controlled for gender and age; and finally, the model was for gender, age, education level, and current smoking. Current smoking status was considered because previous studies have pointed out an association of smoking with eveningness and with depression (Broms et al, 2011(Broms et al, , 2012Wittmann et al, 2010). These models are presented in Table 3.…”

Section: Statisticsmentioning

confidence: 99%

Evening types are prone to depression

Merikanto

Lahti

Kronholm

et al. 2013

Chronobiology International

210

114

View full text Add to dashboard Cite

Certain preferences for the timing of daily activities (chronotype) may predispose an individual to sleep problems and mood disorders. In this study, we have examined the link between chronotypes and depression. Participants (N ¼ 6071) were recruited from a random sample of the general population aged 25 to 74 yrs living in defined geographical areas, as part of the National FINRISK Study in 2007 in Finland. Chronotype assessment was based on six items from the original Horne-Ö stberg Morningness-Eveningness Questionnaire. Depression was assessed with four self-reported items, including two probes for a diagnosis of a major depressive episode, diagnosed or treated depression, and use of antidepressants. We also analyzed correlations between chronotype and several health indicators, such as systolic and diastolic blood pressures, resting heart rate, weight, and waist circumference. The odds ratios for a range of indicators of depression were higher for evening types (2.7-to 4.1-fold) and intermediate types (1.5-to 1.9-fold) than for morning types. Our results suggest that individuals having a preference for evening hours to carry out their daily activities are prone to depression. (Author correspondence: ilona.merikanto@helsinki.fi)

show abstract

Diurnal Evening Type is Associated with Current Smoking, Nicotine Dependence and Nicotine Intake in the Population Based National FINRISK 2007 Study

Cited by 24 publications

References 54 publications

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism

Behavioral Trait of Morningness-Eveningness in Association with Articular and Spinal Diseases in a Population

Evening types are prone to depression

Contact Info

Product

Resources

About