Diurnal Levels of Immunoreactive Erythropoietin in Normal Subjects and Subjects with Chronic Lung Disease

Abstract

Serum levels of immunoreactive erythropoietin (Ep) were measured in 48 normal male and female volunteers, ages 20-60 years, to establish a control value for Ep of 18.5 +/- 5.0 (mean +/- SD) mU/ml. Levels of the hormone were also measured sequentially over a 24 h period of time in an additional 17 'normal' volunteers with no diurnal variation. Diurnal levels of immunoreactive Ep were also measured in 30 subjects, with chronic lung disease. These patients, in contrast to normal subjects exhibited a diurnal variation in the level of immunoreactive Ep with peak levels occurring at midnight. The only variable measured which correlated with the serum immunoreactive Ep level in subjects with chronic lung disease was the level of carboxyhaemoglobin (P less than 0.02).

Perturbação respiratória durante o sono em doença pulmonar obstrutiva crônica

“…Cardiovascular issues should be addressed, as there is increased number of ectopic beats during sleep in these patients despite no current evidence of clinical relevance (92) . We have for instance shown in a very limited subset of patients that REMrelated desaturations have an impact on left ventricular ejection fraction that is comparable to maximal exercise (93) . Actually, very little tissular impacts of nocturnal hypoxemia have been established in patients with COPD.…”

Erythropoïétines et dopage : utilisations actuelles, nouvelles perspectives et méthodes de détection

“…Le taux basai d'éry-thropoïétine dans le sérum chez l'homme sain est de 13 à 28 mUI/ml. Certains auteurs ont observé des variations diurnes des concentrations en érythropoïétine endogène (9,10,11) tandis que d'autres n'ont pas trouvé de variations (12,13,14).…”

Erythropoietin in health and disease

“…Assuming a specific activity of the hormone of about 100 000 iu mg-I, this corresponds to about 100-250 pg ml-' or 3-8 pM. Diurnal variations in the EPO levels are not a consistent finding [67], though they have once been reported [68]. The median apparent volume of distribution of recombinant EPO was determined to be 0-073 1 kg-' corresponding to 1-5 to two-fold the plasma volume [60].…”