Diurnal pH changes in duodenum of conscious dogs

R, Honda; Aizawa, I

doi:10.1152/ajpgi.1980.238.2.g91

Cited by 11 publications

(8 citation statements)

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“…At the time duodenal pH fluctuates considerably although there is a gradual overall acidification of the duodenum as the hunger contractions continue. This differs slightly from results recently reported (Itoh, Honda & Aizawa, 1980). These suggested that the duodenal pH remains alkaline throughout the motility cycle in the interdigestive state in the dog; the fluctuations were small and transient.…”

Section: Discussioncontrasting

confidence: 97%

Gastric pH changes associated with duodenal motility in fasted dogs.

Buéno¹,

Fioramonti²,

Ruckebusch³

1981

The Journal of Physiology

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SUMMARY1. The electrical activity of the antrum and duodenum was recorded from chronically implanted electrodes in six conscious dogs fitted with gastric and/or duodenal cannulae. Antral and duodenal pH were concomitantly registered using glass electrodes inserted through the respective cannula.2. In dogs fasted for 18-24 h an alkalinization of the antrum of about 5 pH units lasting 15-30 min occurred regularly at 90-120 min intervals at the cessation of a period of antral spiking activity. This antral alkaline period was accompanied by the reflux of intestinal juice into the stomach, as determined by the presence of bile salts in gastric samples.3. The antral pH rise was related to the development of a phase of regular spiking activity (RSA), or activity front, on the proximal duodenum concomitant with the motor quiescence of the antrum. The rise in pH disappeared after occlusion of the pylorus, which prevented the passage of duodenal contents into the antrum.4. It is concluded that the mean antral pH value is 5-8 for half the recording time in fasted dogs, the causative factor of this alkalinization being the regurgitation of duodenal contents into the antrum while quiescent. Accordingly, more alkaline duodenal contents were observed during the occurrence of the RSA phase and the following gastro-duodenal quiescence; then the progressive acidification of the gastric and duodenal contents when the motility reappeared may be an inducing factor of a new RSA phase.

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Section: Discussioncontrasting

confidence: 97%

Gastric pH changes associated with duodenal motility in fasted dogs.

Buéno¹,

Fioramonti²,

Ruckebusch³

1981

The Journal of Physiology

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“…The cyclic difference in phase III between the stomach and the duodenum has been demonstrated sufficiently in studies released so far. [12][13][14][15][16][17][18][19][20] The pH and lateral-axis movement were measured simultaneously to locate the position of the test catheters. The distal pH sensor escaped into the duodenum during the GI-IMC in all of the subjects in whom a conventional pH measurement assembly was used.…”

Section: Discussionmentioning

confidence: 99%

“…and 11-12 c.p.m., respectively. [12][13][14][15][16][17][18][19][20] IMC originating in the stomach were designated as gastrointestinal IMC (GI-IMC), and IMC originating in the duodenum without involving the stomach were designated as intestinal IMC (I-IMC).…”

Section: Classification Of Interdigestive Motilitymentioning

confidence: 99%

Gastric longitudinal shortening may occur during gastric phase III activities in man

Ino

Kusano

Ohwada

et al. 2006

J of Gastro and Hepatol

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“…5-HT 3 antagonists, which inhibit gastric phase III, have no effects on intestinal phase III (30, 31). When we carefully check MMC recordings in dogs, it is obvious that duodenal phase II/ III is frequently antecedent to gastric phase II/ III (1, 36,37,38,39). However, no reasonable explanation has been shown.…”

Section: Gastric MMC and Intestinal Mmcmentioning

confidence: 99%

Interdigestive migrating motor complex -its mechanism and clinical importance

Takahashi

2013

J Smooth Muscle Res

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Migrating motor complex (MMC) is well characterized by the appearance of gastrointestinal (GI) contractions in the interdigestive state. The physiological importance of gastric MMC is a mechanical and chemical cleansing of the empty stomach in preparation for the next meal. MMC cycle is mediated via the interaction between motilin and 5-hydroxytryptamine (5-HT) by the positive feedback mechanism in conscious dogs. Luminal administration of 5-HT initiates duodenal phase II and phase III with a concomitant increase of plasma motilin release. Duodenal 5-HT concentration is increased during gastric phase II and phase III. Intravenous infusion of motilin increases luminal 5-HT content and induces phase III. 5-HT4 antagonists significantly inhibit both of gastric and intestinal phase III, while 5-HT3 antagonists inhibit only gastric phase III. These suggest that gastric MMC is regulated via vagus, 5-HT3/4 receptors and motilin, while intestinal MMC is regulated via intrinsic primary afferent neurons (IPAN) and 5-HT4 receptors. We propose the possibility that maximally released motilin by a positive feedback depletes 5-HT granules in the duodenal EC cells, resulting in no more contractions. Stress is highly associated with the pathogenesis of functional dyspepsia (FD). Acoustic stress attenuates gastric phase III without affecting intestinal phase III in conscious dogs, via reduced vagal activity. Subset of FD patients shows reduced vagal activity and impaired gastric phase III. The impaired gastric MMC may aggravate dyspeptic symptoms following a food ingestion. Maintaining MMC cycle in the interdigestive state is an important factor to prevent the postprandial dyspeptic symptoms.

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Diurnal pH changes in duodenum of conscious dogs

Cited by 11 publications

References 0 publications

Gastric pH changes associated with duodenal motility in fasted dogs.

Gastric pH changes associated with duodenal motility in fasted dogs.

Gastric longitudinal shortening may occur during gastric phase III activities in man

Interdigestive migrating motor complex -its mechanism and clinical importance

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