Diurnal rhythm in the plasma concentration of cortisol in paediatric patients with orthostatic dysregulation

Shibasaki, Hiromi; Furuta, Takahisa; Kasuya, Yasuji; Okabe, Toshinari; Katoh, Takashi; Kogo, Toshiaki; Hirayama, Tsunenori

doi:10.1002/bms.1200190404

Cited by 17 publications

(1 citation statement)

References 14 publications

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“…In the case of the measurement of cortisol in plasma by GC-MS, cortisol is not interfered with the MO-TMS derivative of 6β-OHF, because the concentrations of 6β-OHF in plasma are negligibly low (< 1 ng/ml) [55,56], compared to those of cortisol (20-160 ng/ml plasma) [57].…”

Section: Extraction and Derivatiztion For The Gc-ms Analysismentioning

confidence: 99%

Stable Isotope Dilution Mass Spectrometry Analysis of Endogenous and Synthetic Corticosteroids for the Pharmacokinetic and in vivo Metabolic Investigations in Humans

Furuta¹,

Shibasaki

2006

CPA

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This review article underlines the importance of stable isotope dilution mass spectrometry analysis of endogenous and synthetic corticosteroids for the pharmacokinetic and in vivo metabolic investigations in humans. The multi-labeled corticosteroids with stable isotopes such as H 4 ]cortisol, etc. have been used not only as analytical internal standard for the mass spectrometry but as tracer in the pharmacokinetic and metabolic studies in human in vivo. Stable isotope dilution analysis of cortisol metabolites (tetrahydrocortisol (THF), allo-tetrahydrocortisol (allo-THF), tetrahydrocortisone (THE), and 6β-hydroxycortisol (6β-OHF)) and synthetic corticosteroids (prednisolone, prednisone, budesonide, fluticasone, etc.) is also the subject of this review. In the gas chromatographic mass spectrometric (GC-MS) analysis of corticosteroids, it is usual to employ derivatives in which some or all of the original functional groups are protected. Thermal stabilization of corticosteroids in the analysis has been achieved most successfully by formation of methoxime-trimethylsilyl (MO-TMS) derivatives. Bismethylenedioxy-pentafluoropropionyl (BMD-PFP) derivatives have been developed to simultaneously measure cortisol, cortisone, and their tetrahydrocorticoid metabolites (THF, allo-THF, and THE) and/or prednisolone and prednisone in plasma and urine. Stable isotope tracer methodology has been applied to the measurements of cortisol production rate, determination of human urinary cortisol metabolites, and assessment of in vivo activities of 11β-hydroxysteroid dehydrogenase (11β-HSD) in humans. This methodology also has been used for the validity of endogenous cortisol 6β-hydroxylation clearance as a new index for phenotyping the in vivo cytochrome P450 3A (CYP3A) in humans.

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Section: Extraction and Derivatiztion For The Gc-ms Analysismentioning

confidence: 99%

Stable Isotope Dilution Mass Spectrometry Analysis of Endogenous and Synthetic Corticosteroids for the Pharmacokinetic and in vivo Metabolic Investigations in Humans

Furuta¹,

Shibasaki

2006

CPA

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Syntheses and Uses of Isotopically Labelled Dienes and Polyenes

Zieliński¹,

Kańska²

2009

Patai's Chemistry of Functional Groups

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Introduction Synthesis of Dienes and Polyenes Labelled with Stable Isotopes Synthesis and Uses of Dienes and Polyenes Labelled with Tritium Synthesis and Uses of Dienes and Polyenes Labelled with Radioisotopes of Carbon Synthesis and Uses of Dienes and Polyenes Labelled with Heavy Radioisotopes Isotope Effect Studies with Dienes and Polyenes Acknowledgements

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Syntheses and Uses of Isotopically Labelled Compounds ContainingCC,COorCNGroups

Zieliński

Kańska

2009

Patai's Chemistry of Functional Groups

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Introduction Syntheses and Uses of Compounds Containing C  C , C  O or C  N Groups Labelled with Stable Isotopes Synthesis and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Tritium Syntheses and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Radioactive Carbon Syntheses and Uses of Compounds Containing C  C , C  O or CN Groups Labelled with Radioactive Halogen Synthesis and Uses of Compounds Containing C  C , C  O , or CN Groups Labelled with Radioactive Sulphur Isotope Effect Studies Acknowledgements

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Diurnal rhythm in the plasma concentration of cortisol in paediatric patients with orthostatic dysregulation

Cited by 17 publications

References 14 publications

Stable Isotope Dilution Mass Spectrometry Analysis of Endogenous and Synthetic Corticosteroids for the Pharmacokinetic and in vivo Metabolic Investigations in Humans

Stable Isotope Dilution Mass Spectrometry Analysis of Endogenous and Synthetic Corticosteroids for the Pharmacokinetic and in vivo Metabolic Investigations in Humans

Syntheses and Uses of Isotopically Labelled Dienes and Polyenes

Syntheses and Uses of Isotopically Labelled Compounds ContainingCC,COorCNGroups

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