Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism

Rejnmark, Lars; Lauridsen, Anna Lis; Vestergaard, Peter; Heickendorff, Lene; Andreasen, F.; Mosekilde, Leif

doi:10.1530/eje.0.1460635

Cited by 76 publications

(55 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, this is the first observation of diurnal variation in serum 25-OHD. Diurnal rhythm of 1,25-dihydroxyvitamin D and other markers of bone mineral metabolism was shown previously (Greenspan et al, 1997;Rejnmark et al, 2002). Multiple regression models explained only a small fraction of the variance in vitamin D status.…”

Section: Discussionmentioning

confidence: 51%

Vitamin D status and health correlates among German adults

et al. 2007

View full text Add to dashboard Cite

Objective: To analyze vitamin D status based on serum 25-hydroxyvitamin D (25OHD) measurements, its determinants and health correlates in a representative sample of German adults. Subjects: A total of 1763 men and 2267 women, 18-to 79-year old, who participated in the representative German National Health Interview and Examination Survey 1998 and the integrated German Nutrition Survey. Results: The median vitamin D intake from both diet and supplements did not meet the recommended level of 5 mg/day, in either men (2.8 mg/day) or women (2.3 mg/day). Altogether 80.9% of men and 88.5% of women had vitamin D intakes below this level. Moderate (12.5-25 nmol/l serum 25OHD levels) and mild (25-50 nmol/l) vitamin D deficiency was prevalent in the adult population in Germany, even in younger age groups. Overall, 57% of men and 58% of women had vitamin D levels below 50 nmol/l. Among 65-to 79-year-old women, the proportion amounted to 75%, even during the sunnier half of the year. In sexspecific multiple linear regression models, independent determinants of serum 25OHD levels consistently included season, vitamin D intake from both diet and supplements, physical activity and living in a partnership. In addition, age and current menopausal hormone use contributed to the model among women, as opposed to time of day of blood sampling and body mass index (marginally) among men. Significantly lower serum 25OHD levels were observed in women with hypertension, cardiovascular diseases and noninsulin-treated diabetes mellitus as well as in men with insulin-treated diabetes mellitus compared with nonaffected participants. Conclusions: Vitamin D deficiency is a public health issue in Germany. We identified a number of determinants with potential for primary prevention of vitamin D deficiency. Risk and benefits of preventive actions need to be examined in further studies.

show abstract

Section: Discussionmentioning

confidence: 51%

Vitamin D status and health correlates among German adults

et al. 2007

View full text Add to dashboard Cite

show abstract

“…A significant body of literature examining serum protein biomarkers supports a role for circadian mechanisms in bone metabolism in both experimental models and clinical investigations in humans [120,[126][127][128][129][130][131][132][133][134][135][136]. These findings all have potential clinical implications relating to bone metabolism and patient care.…”

Section: The Circadian Clock and Clinical Treatmentsmentioning

confidence: 95%

A fluorescence spotlight on the clockwork development and metabolism of bone

et al. 2011

View full text Add to dashboard Cite

Biological phenomena that exhibit periodic activity are often referred as biorhythms or biological clocks. Among these, circadian rhythms, cyclic patterns reflecting a 24-h cycle, are the most obvious in many physiological activities including bone growth and metabolism. In the late 1990s, several clock genes were isolated and their primary structures and functions were identified. The feedback loop model of transcriptional factors was proposed to work as a circadian core oscillator not only in the suprachiasmatic nuclei of the anterior hypothalamus, which is recognized as the mammalian central clock, but also in various peripheral tissues including cartilage and bone. Looking back to embryonic development, the fundamental architecture of skeletal patterning is regulated by ultradian clocks that are defined as biorhythms that cycle more than once every 24 h. As post-genomic approaches, transcriptome analysis by micro-array and bioimaging assays to detect luminescent and fluorescent signals have been exploited to uncover a more comprehensive set of genes and spatio-temporal regulation of the clockwork machinery in animal models. In this review paper, we provide an overview of topics related to these molecular clocks in skeletal biology and medicine, and discuss how fluorescence imaging approaches can contribute to widening our views of this realm of biomedical science.

show abstract

“…Chronic values higher than 200 pmol/l might be toxic and values under 25 pmol/ l might cause rickets. Values in different publications rank between 65-165 pmol/l, 29-168 pmol/l and 75-200 pmol/ l (e.g., Gibbs and Peacock 1986;Rejnmark et al 2002;Guder and Nolte 2009). …”

Section: Measurement Of 125 (Oh) 2 Dmentioning

confidence: 99%