Diurnal variation in SARS-CoV-2 PCR test results: Test accuracy may vary by time of day

McNaughton, Candace D.; Adams, Nicholas M.; Johnson, Carl Hirschie; Ward, Michael J.; Lasko, Thomas A.

doi:10.1101/2021.03.12.21253015

Cited by 10 publications

(11 citation statements)

References 9 publications

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“…This may reflect differences between the cohorts studied, particularly with regard to immune status; we studied seronegative participants whereas responses to influenza vaccination will involve the stimulation of memory responses. Sample collection time in this study showed no significant association with anti-Spike levels, in contrast to previous reports (Kurupati et al, 2017;McNaughton et al, 2021). These data highlight the importance of It is worth noting that, despite the significant differences in anti-Spike levels detected in participants receiving Pfizer mRNA or AstraZeneca Adenoviral vaccines, both show comparable efficacies highlighting the robust nature of the host antibody response.…”

contrasting

confidence: 92%

Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of healthcare workers

Wang

Balfe

Eyre

et al. 2021

Preprint

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The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time-of-day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, age, sex, and days post-vaccination on anti-Spike antibody responses in healthcare workers. The magnitude of the anti-Spike antibody response associated with the time-of-day of vaccination, vaccine type, participant age, sex, and days post vaccination. These results may be relevant for optimizing SARS-CoV-2 vaccine efficacy.

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contrasting

confidence: 92%

Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of healthcare workers

Wang

Balfe

Eyre

et al. 2021

Preprint

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“…A study conducted in the United States in 2020 reported that positive tests showed a sinusoidal pattern with a peak point of 1:49 PM, 24 hours a day. 18 They also reported that the rate of positive tests at the peak point was 2.2 times higher than that at the lowest point of the curve. Therefore, the sinusoidal pattern in this study shows that the amount of virus in the mucosa varies with the cyclic pattern and the maximum amount at the beginning of each day.…”

Section: Discussionmentioning

confidence: 96%

Viral contamination of acrylic resin removable denture bases in patients with COVID-19: A cross-sectional study

Gorji¹,

Salehabadi²,

Zakariaei³

et al. 2023

The Journal of Prosthetic Dentistry

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Statement of problem Salivary gland ducts are one of the primary targets of severe acute respiratory syndrome coronavirus 2. Moreover, saliva contains minor and major salivary gland secretions and a combination of nasopharyngeal and lung secretions. The acrylic resin bases of complete or partial removable dentures have pores and provide a favorable environment for the growth of microorganisms. Purpose The purpose of this cross-sectional study was to investigate the presence of viral contamination of acrylic resin removable denture bases in patients with coronavirus disease 2019 (COVID-19). Material and methods The acrylic resin denture bases (partial and complete) of 29 patients with COVID-19 who underwent treatment in the Infectious Diseases Department of Razi Hospital in Ghaemshahr, Mazandaran, Iran were evaluated. Samples were collected from the intaglio surface of the prostheses by direct swabbing and coding and were evaluated in a laboratory for the presence or absence of coronavirus. The relationship between hospital polymerase chain reaction (PCR) and denture PCR and the relationship between denture type and denture PCR was evaluated with the Fisher exact test (α=.05). Results Twenty-nine patients, age range 55 to 85 years, 18 women, 3 with partial dentures and 26 with complete dentures, were evaluated. The hospital PCR test was positive in 28 patients, while the denture PCR test was positive in 4 patients. No significant relationship was observed between the results of hospital PCR and denture PCR in patients with COVID-19 ( P =.138). All 4 patients who tested positive for denture PCR had complete dentures. No significant relationship was found between denture type and denture PCR test results in patients with COVID-19 ( P =1.000). Conclusions Despite the microporous structure of the acrylic resin base, no statistically significant viral contamination was observed.

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“…A twofold variation was observed in the proportion of positive results across a 24 h period with a peak of positivity in the early afternoon (around 14.00). This suggests that the test results were most likely to be positive (less likely to be false negative) in the early afternoon compared with other times of day [ 12 ]. This observation is likely to be attributed to a combination of the circadian-regulated immune system and host pathways essential for SARS-CoV-2 replication, resulting in a fluctuation of viral shedding throughout the day.…”

Section: Viral Shedding May Be Dependent On the Time Of Daymentioning

confidence: 99%

COVID-19, circadian rhythms and sleep: from virology to chronobiology

2021

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Various aspects of our physiology and immune response to pathogens are under 24 h circadian control and its role in clinical and research practice is becoming increasingly recognized. Severe acute respiratory syndrome coronavirus-2, the causative agent of Coronavirus disease 2019 (COVID-19) has affected millions of people to date. Cross-disciplinary approaches and collaborative efforts have led to an unprecedented speed in developing novel therapies and vaccines to tackle the COVID-19 pandemic. Circadian misalignment and sleep disruption have a profound impact on immune function and subsequently on the ability of individuals to combat infections. This review summarizes the evidence on the interplay between circadian biology, sleep and COVID-19 with the aim to identify areas of translational potentials that may inform diagnostic and therapeutic strategies in this pandemic.

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Diurnal variation in SARS-CoV-2 PCR test results: Test accuracy may vary by time of day

Cited by 10 publications

References 9 publications

Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of healthcare workers

Time of day of vaccination affects SARS-CoV-2 antibody responses in an observational study of healthcare workers

Viral contamination of acrylic resin removable denture bases in patients with COVID-19: A cross-sectional study

COVID-19, circadian rhythms and sleep: from virology to chronobiology

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