Diurnal Variation of Plasma Vasopressin in Man*

George, Claude P. L.; Messerli, Franz H.; Genest, Jacques; Nowaczynski, W.; Boucher, R.; Küchel, Otto; Rojo-Ortega, Manuel

doi:10.1210/jcem-41-2-332

Cited by 184 publications

(77 citation statements)

References 17 publications

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“…It seems to be a multifactorial entity and several factors have been implicated. Genetic (5), neurological (6,7) and hormonal factors (8) can in¯uence the balance between bladder capacity and nocturnal urinary production, which ultimately appears to be the determinant in inducing enuresis. In the past few years the discovery of an absent circadian rhythm of production of antidiuretic hormone (arginine vasopressin, AVP) in monosymptomatic patients with enuresis (9,10) led to treatment with 1-desamino-8-d-arginine vasopressin (DDAVP), an antidiuretic hormone analogue; about one-third of the patients, however, do not respond to this kind of therapy (11).…”

Section: Introductionmentioning

confidence: 99%

Urinary aquaporin-2 excretion in nocturnal enuresis

Radetti

Paganini

Rigon

et al. 2001

European Journal of Endocrinology

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Objective: To evaluate the role of the arginine vasopressin (AVP)±aquaporin-2 (AQP-2) axis in the pathogenesis of nocturnal enuresis. Study participants: Twelve children (seven male and ®ve female), aged 11X6^4X3 (6.7±15.6) years, suffering from primary monosymptomatic nocturnal enuresis and 12 healthy children, matched for sex and age. Enuretic children were further subdivided into responders and non-responders to treatment with 1-desamino-8-d-AVP (DDAVP). Methods: Serum concentrations of AVP, and plasma and urine osmolality were measured at night (0100, 0400 and 0700 h), together with nocturnal urinary excretion of AQP-2 (2000±0800 h). Magnetic resonance imaging (MRI) of the pituitary gland was carried out to evaluate the amount of AVP stored in the posthypophysis. Results: Mean AVP serum concentrations were similar in patients and controls. Urinary AQP-2 was also similar in patients and controls, but responders had a signi®cantly lower level of AQP-2 than non-responders P , 0X005X Plasma osmolality was greater in patients than in controls P , 0X001Y whereas urinary osmolality was similar in both groups. No difference in the ratio of the signal intensity of the posterior lobe of the hypophysis to that of the pons (AVP content) was found between patients and controls or between responders and non-responders. Conclusion: A decreased urinary excretion of AQP-2 is associated with, and seems to have a role in, nocturnal enuresis, at least in some children, and this could also explain why only some of them respond to DDAVP treatment.

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Section: Introductionmentioning

confidence: 99%

Urinary aquaporin-2 excretion in nocturnal enuresis

Radetti

Paganini

Rigon

et al. 2001

European Journal of Endocrinology

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“…This elevation is not the result of a known endogenous rhythm, because AVP does not exhibit circadian variation during light hours in mammalian species, including man [27], although small, random nocturnal fluctuations of AVP averaging 0.6/~U/ml have been reported [13,15,29].…”

Section: Discussionmentioning

confidence: 99%

Hormonal control in a state of decreased activation: Potentiation of arginine vasopressin secretion

O’Halloran

Jevning

Wilson

et al. 1985

Physiology & Behavior

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PHYSIOL BEHAV 35(4) 591-595, 1985 --Behaviorally induced stress is associated with increased arginme vasopressln (AVP) secretion. In this report we describe a phasic conditioned response of AVP secretion yielding 2.6--7.1 times normal plasma concentration of this hormone m assocmtlon w~th a physmlog~cal state of decreased activation, that associated with the mental technique of "transcendental meditation" (TM) in long-term practltmners (6-8 years of regular elicitation) Such a very large phastc response of AVP was previously unknown m the normal physmlogy of AVP. This elevation was not accompanied by elevatmn of plasma osmolality. Unstyllzed ordinary eyes closed rest in a separate group of subjects studied in the same manner was associated with normal plasma AVP concentration. Galvanic skin resistance (GSR) increased dunng both TM and rest with significantly larger increase assocmted with TM. Other measures of activation, including muscle metabolism, and the Spielberger Anxiety Inventory indicated marked relaxatmn in associatmn with TM. In previous research it has been shown that blood pressure does not change acutely dunng th~s behavmr. These observations in&cate that neither stress nor operatmn of other usual homeostatic control mechamsms are responsible for elevated for AVP in the meditators. It is speculated that the apparently unique mechanism of TM-mduced AVP secretion may be more specifically related to the behavmral effects of meditatmn. [5,7,8] and, more specifially, the acquisition and retention of adaptive behavior patterns [4,8]. Additional reported effects of AVP in humans suggest psychotherapeutic and behavior-modifying properties [9,34] as well as improvement of attentional processes [ 1]. Implicit in many of these reports is the notion that naturally occurring modification of existing, or acquisition of new behavior patterns may be facilitated by an increase of endogenous AVP activity centrally and/or peripherally. However, except for states of stress, potentiation of AVP secretion associated with behavior modification or adaptation has not been demonstrated. The purpose of the present study was to determine if long-term, regular practice of the technique of "transcendental meditation" (TM), reported to induce numerous behavioral changes [10,12,16,22,28], may be associated with altered secretion of AVP. This behavior, elicited twice daily in the morning and evening for 20--40 minute periods by the regular practitioner, is associated with major physiologic changes in long-term subjects [17][18][19]. Hormones METHODTwelve subjects, six long-term meditation practitioners (5-10 year instructors of TM) and six non-meditating individuals ("ordinary rest" group), were studied. All subjects were normal, university educated individuals and did not use tobacco, alcohol or regular medication. Their ages ranged 1Requests for reprints should be addressed to R. Jevning, Departments of Medicine and Physiology, University of Califorma, Irvine, Irvme, CA 92717. The additional point for the TM group represent...

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“…Serum osmolality was measured by the freezing point depression method. 7 Statistical analysis was performed with the computer software program SPSS for Windows, utilizing the Wilcoxon matched-pairs signed-ranks test for paired samples, and the oneway ANOVA test.…”

Section: Methodsmentioning

confidence: 99%

Diurnal variation of antidiuretic hormone and urinary output in spinal cord injury

et al. 1999

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Introduction: Healthy individuals have a nocturnal decrease in urine output due to increased plasma antidiuretic hormone levels at night. This does not occur in spinal cord injury and most patients experience nocturnal polyuria, which triggers dysre¯exic crises secondary to urinary bladder overdistension, and interferes with patients' sleep due to the need for extra catheterization. Objective: To evaluate the diurnal variation in ADH level, urinary output, and plasma and urine osmolality in SCI patients with regard to their level of injury and in comparison with age-and sex-matched healthy individuals. Materials and methods: Sixteen ASIA-A spinal cord-injured patients, eight with paraplegia, eight with tetraplegia, and eight healthy individuals, were evaluated for urinary output, urine and serum osmolality, and antidiuretic hormone levels during day and night hours. Results: Absence of diurnal variation in urinary output and antidiuretic hormone secretion was detected in both paraplegic and tetraplegic patients, while antidiuretic hormone levels rose signi®cantly at night in the control group. Conclusion: Antidiuretic hormone levels should be monitored both day and night in spinal cord injury patients with severe nocturnal polyuria. Treatment with desaminocystein-Darginine vasopressin can be attempted when conservative measures fail to control nocturnal polyuria, especially in patients who are on an intermittent catheterization program.

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Diurnal Variation of Plasma Vasopressin in Man*

Cited by 184 publications

References 17 publications

Urinary aquaporin-2 excretion in nocturnal enuresis

Urinary aquaporin-2 excretion in nocturnal enuresis

Hormonal control in a state of decreased activation: Potentiation of arginine vasopressin secretion

Diurnal variation of antidiuretic hormone and urinary output in spinal cord injury

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