Diurnal Variation of the Serum Cortisol Level of Geriatric Subjects

Grad, B; Rosenberg, Gilbert; Liberman, H; Trachtenberg, John; Kral, V. A.

doi:10.1093/geronj/26.3.351

Cited by 18 publications

(6 citation statements)

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“…Overall, the balance of the data appears to indicate that basal, nonstimulated HPA activity remains essentially unchanged at older ages as seen in both patient (111,115,117,123) and healthy samples (108,113,122,125,128,129,131,132). In addition, there does not appear to be evidence for any gender difference as both men and women show similar conservation of circadian rhythmicity with age (108,113,117,124,129).…”

Section: B Nonstimulated Hpa Functionmentioning

confidence: 88%

“…Although the study does not include its own comparison group of healthy older men, similar 2200 h plasma cortisol levels from samples of healthy older men (aged 65-87, mean age 75.3) generally show mean cortisol levels of <5 MgM (113,166,168), suggesting that patients with chronic diseases had elevated evening cortisol levels. Grad et al (124) also found that older subjects with heart disease and diabetes had significantly higher morning and evening cortisol levels compared with healthy controls of similar age (67+). As indicated earlier, Greenspan et al (163) also found that individuals suffering from diabetes or high blood pressure had higher peak cortisol response to oCRF challenge as well as more prolonged response when compared to "healthy" subjects.…”

Section: Health Consequences Of Elevated Gcs In Humansmentioning

confidence: 91%

“…Circadian rhythms also appear to remain generally unchanged with age for ACTH (113,123) and cortisol (113,115,117,(123)(124)(125)(126)(127)(128)(129). Trends have been reported, however, showing higher evening (111,130) or morning (128) cortisol levels at older ages; higher 24-h mean cortisol concentrations at older ages have also been reported (122,129) although others have not found such differences by age (123,131).…”

Section: B Nonstimulated Hpa Functionmentioning

confidence: 96%

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Aging and Hypothalamic-Pituitary-Adrenal Response to Challenge in Humans*

1994

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Section: B Nonstimulated Hpa Functionmentioning

confidence: 88%

Section: Health Consequences Of Elevated Gcs In Humansmentioning

confidence: 91%

Section: B Nonstimulated Hpa Functionmentioning

confidence: 96%

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Aging and Hypothalamic-Pituitary-Adrenal Response to Challenge in Humans*

1994

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“…45,47,48 There is limited additional evidence from studies comparing poorly characterized groups of patients with various diseases (including cardiovascular disease) with subjects without these diseases, which suggests that blood cortisol levels may be related to cardiovascular disease. 49,50 Endogenous corticosteroid treatment has also been associated with elevated cardiovascular disease risk, 51,52 and evidence from animal studies suggests detrimental effects on cardiovascular health of elevated cortisol. 53 In the only prospective study to date, elevated urinary cortisol level was combined with other physiological indicators (blood pressure, waist-hip ratio, total cholesterol/HDL cholesterol ratio, glycosylated hemoglobin, urinary norepinephrine, and urinary epinephrine levels) to produce an index of "allostatic load."…”

Section: Discussionmentioning

confidence: 99%

Cortisol, Testosterone, and Coronary Heart Disease

et al. 2005

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Background-There is a popular belief that chronic stress causes heart disease through psychoneuroendocrine mechanisms. We have examined whether an elevated circulating cortisol-to-testosterone ratio increases the risk of ischemic heart disease. Methods and Results-We undertook a prospective cohort study of 2512 men aged 45 to 59 years between 1979 and 1983 from Caerphilly, South Wales, with a mean follow-up of 16.5 years. Subjects underwent a clinical examination, and morning fasting blood samples were taken for analysis of cortisol levels, testosterone levels, and other cardiovascular risk factors. The ratio of cortisol to testosterone showed weak associations with potential confounding factors but strong positive associations with components of the insulin resistance syndrome (PϽ0.001). A positive linear trend was seen across quintiles of cortisol:testosterone ratio for incident ischemic heart disease (age-adjusted OR per z score change in ratio 1.22, 95% CI 1.07 to 1.38, Pϭ0.003). This was markedly attenuated after adjustment for components of the insulin resistance syndrome (age-adjusted OR per z score change in ratio 1.10, 95% CI 0.96 to 1.25, Pϭ0.18). There was no association between the cortisol:testosterone ratio and other causes of death (age-adjusted hazard ratio 0.99, 95% CI 0.88 to 1.11, Pϭ0.81). Conclusions-This is the first population-based prospective study that has found a specific association between cortisol:testosterone ratio and incident ischemic heart disease, apparently mediated through the insulin resistance syndrome. Whether this reflects the effects of chronic stress, behavioral factors, or genetic influences remains to be determined. (Circulation. 2005;112:332-340.)

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“…Numerous studies have reported that diurnal rhythmicity of cortisol [254,257,[269][270][271][272][273][274][275][276][277][278][279][280] and ACTH [238,263] is also unaffected by aging in both sexes, but there are some exceptions. For example, some studies reported higher evening [251,281] and morning [278] cortisol levels at older ages; higher 24h mean cortisol concentrations at older ages have also been reported in both men and women [269,270,272,281,282].…”

Section: Humansmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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Diurnal Variation of the Serum Cortisol Level of Geriatric Subjects

Cited by 18 publications

References 0 publications

Aging and Hypothalamic-Pituitary-Adrenal Response to Challenge in Humans*

Aging and Hypothalamic-Pituitary-Adrenal Response to Challenge in Humans*

Cortisol, Testosterone, and Coronary Heart Disease

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

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