Diurnal variations of serum leptin in dogs: effects of fasting and re-feeding

Ishioka, Katsumi; Hatai, Hitoshi; Komabayashi, K.; Soliman, Mohamed Mohamed; Shibata, Haruki; Honjoh, Tsutomu; Kimura, Kazuhiro; Saito, Masayuki

doi:10.1016/j.tvjl.2004.01.003

Cited by 35 publications

(34 citation statements)

References 22 publications

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“…The assessment of the nutritional condition was based on a five-scale BCS. Since we have previously found that plasma leptin concentration is increased 2 -10 hours (hr) after food intake (Ishioka et al, 2005), administration of insulin (Ishioka et al, 2005) and glucocorticoids (Ishioka et al, 2002a), in the present study, we carefully assessed the individual records, and only used blood samples collected from 166 dogs that had been fasted for at least 10 hr and not treated with insulin and/or glucocorticoids.…”

Section: Subjects and Sample Collectionmentioning

confidence: 99%

Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds

Ishioka

Hosoya

Kitagawa

et al. 2007

Research in Veterinary Science

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Leptin is a cytokine produced by adipocytes, and plays a key role in the regulation of energy balance. In the present study, we measured plasma leptin concentrations of 166 normal and obese dogs visiting veterinary practices, and clarified the influence of age, gender and breed on plasma leptin levels in dogs. Leptin levels were higher in the dogs with higher body condition scores. There was no noticeable influence of age, gender and breed, but those in optimal puppies and obese Miniature Dachshund tended to be lower than those in corresponding groups. We conclude that plasma leptin is a reliable marker of adiposity in dogs regardless of age, gender and breed variations, and thereby useful as a blood biochemistry test for health examinations and treatment of obesity.2

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Section: Subjects and Sample Collectionmentioning

confidence: 99%

Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds

Ishioka

Hosoya

Kitagawa

et al. 2007

Research in Veterinary Science

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“…However, the patients included in some of these studies had received treatments such as insulin administration. Since insulin administration positively affects the blood leptin concentration [6,8], the discrepancy in the leptin concentration among the previous studies might be due to the difference in experience of the treatments. Indeed, insulin treatment significantly increases the leptin concentration in patients with type 1 diabetes [5].…”

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confidence: 96%

“…Other than adiposity, insulin is one of factors that regulate the plasma leptin concentration, and it has been shown that an insulin administration increases the plasma leptin concentration [8]. Insulin administration has also been shown to increase the plasma leptin concentration in dogs [6]. Since leptin has an intimate involvement in insulin secretion or insulin resistance [16], it can contribute to the pathophysiology of diabetes mellitus.…”

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confidence: 99%

“…One of possible causes for the disturbance of leptin concentration in diabetic dogs is insulin deficiency. Because insulin administration increases the blood leptin concentration [6,8], deficiency of insulin effect can result in a low blood leptin concentration. However, the plasma insulin concentration in the diabetic dogs showed no correlation with the plasma leptin concentration, was not significantly different from that in the normal dogs.…”

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Plasma Leptin Concentration in Dogs with Diabetes Mellitus

Nishii

Yamasaki

Takasu

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. The plasma leptin concentration was evaluated in dogs with diabetes mellitus. Twenty normal and sixteen diabetic dogs were divided into nonobese and obese groups based on body condition score, respectively. The obese normal dogs had significantly higher plasma leptin concentrations than the nonobese normal dogs, whereas there was no significant difference between the nonobese and obese diabetic dogs. In addition, the plasma leptin concentration in the obese diabetic dogs was significantly lower than that in the obese normal dogs. In conclusion, the plasma leptin concentrations in the diabetic dogs were affected by factors other than adiposity.

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“…Being aware of the effects of diurnal variations, food intake and certain medications on serum leptin concentration (Ishioka et al, 2002b;Ishioka et al, 2005b), we used only blood samples collected from dogs that had been fasted for at least 10 h and not treated with insulin or glucocorticoids. Blood glucose was measured using an automatic analyzer (Dcont Personal) with a commercial kit, immediately after blood collection.…”

Section: Sample Collection and Hormone Assaymentioning

confidence: 99%

Body fat distribution and metabolic consequences — Examination opportunities in dogs

Müller

Kollár

Pöstényi

et al. 2014

Acta Veterinaria Hungarica

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The relationship between metabolic disorders and the distribution of fat in different body regions is not clearly understood in humans. The aim of this study was to develop a suitable method for assessing the regional distribution of fat deposits and their metabolic effects in dogs. Twenty-five dogs were subjected to computed tomographic (CT) imaging and blood sampling in order to characterise their metabolic status. The different fat areas were measured on a cross-sectional scan, and the animals' metabolic status was evaluated by measuring fasting glucose, insulin and leptin levels. The volume of visceral adipose tissue is the main determinant of leptin levels. The correlation of visceral fat volume and leptin concentration was found to be independent of insulin levels or the degree of insulin resistance. There was a positive correlation between the visceral to subcutaneous fat volume ratio and serum insulin concentration, and a similar trend was observed in the relationship of fat ratio and insulin resistance. The distribution of body fat essentially influences the metabolic parameters in dogs, but the effects of adiposity differ between humans and dogs. The findings can facilitate a possible extrapolation of results from animal studies to humans with regard to the metabolic consequences of different obesity types. Key words: Leptin, insulin resistance, abdominal fat, computed tomographyObesity is a growing problem in companion animals just like in humans. The development of insulin resistance, dyslipidaemia and other metabolic problems appear to be more closely related to the regional distribution of body fat than simply to adiposity or body weight. Even though the phenotypes of human obesity that represent specific risk factors for metabolic disorders have not been reported in dogs, differences in the metabolic effects of increased visceral or

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Diurnal variations of serum leptin in dogs: effects of fasting and re-feeding

Cited by 35 publications

References 22 publications

Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds

Plasma leptin concentration in dogs: Effects of body condition score, age, gender and breeds

Plasma Leptin Concentration in Dogs with Diabetes Mellitus

Body fat distribution and metabolic consequences — Examination opportunities in dogs

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