Divergence history of the Carpathian and smooth newts modelled in space and time

Zieliński, Piotr; Nadachowska‐Brzyska, Krystyna; Dudek, Katarzyna; Babik, Wiesław

doi:10.1111/mec.13724

Cited by 23 publications

(44 citation statements)

References 98 publications

(218 reference statements)

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“…Previous studies have suggested some spatial, temporal and genomic heterogeneity of introgression Zieliński, Dudek, Stuglik, Liana, & Babik, 2014;Zieliński et al, 2016Zieliński et al, , 2013. Demographic models have suggested asymmetry of historical gene flow, predominantly into Lm, within the IN zone (Zieliński et al, 2016). Heterogeneity and asymmetry of introgression were also suggested by detection of two chromosomal blocks grouping genes exhibiting segregation distortion in F 2 interspecific hybrids (Niedzicka, Dudek, Fijarczyk, Zieliński, & Babik, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Differential introgression across newt hybrid zones: Evidence from replicated transects

et al. 2019

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Genomic heterogeneity of divergence between hybridizing species may reflect heterogeneity of introgression, but also processes unrelated to hybridization. Heterogeneous introgression and its repeatability can be directly tested in natural hybrid zones by examining multiple transects. Here, we studied hybrid zones between the European newts Lissotriton montandoni and two lineages of Lissotriton vulgaris, with replicate transects within each zone. Over 1,000 nuclear genes located on a linkage map and mitochondrial DNA were investigated using geographical and genomic clines. Overall, the five transects were all similar, showing hallmarks of strong reproductive isolation: bimodal distribution of genotypes in central populations and narrow allele frequency clines. However, the extent of introgression differed between the zones, possibly as a consequence of their different ages, as suggested by the analysis of heterozygosity runs in diagnostic markers. In three transects genomic signatures of small‐scale (~2 km) zone movements were detected. We found limited overlap of cline outliers between transects, and only weak evidence of stronger differentiation of introgression between zones than between transects within zones. Introgression was heterogeneous across linkage groups, with patterns of heterogeneity similar between transects and zones. Predefined candidates for increased or reduced introgression exhibited only a subtle tendency in the expected direction, suggesting that interspecific differentiation is not a reliable indicator for the strength of introgression. These hierarchically sampled hybrid zones of apparently different ages show how introgression unfolds with time and offer an excellent opportunity to dissect the dynamics of hybridization and architecture of reproductive isolation at advanced stages of speciation.

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Section: Introductionmentioning

confidence: 99%

“…Previous work on mtDNA phylogeography and nuclear gene genealogies (Babik et al, 2005;Pabijan et al, 2017;Zieliński et al, 2016Zieliński et al, , 2013 has testified to a long history of genetic exchange be-…”

Section: Extent Of Introgression and The Age Of The Zonesmentioning

confidence: 99%

Differential introgression across newt hybrid zones: Evidence from replicated transects

et al. 2019

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“…So far there has been no information about the strength and form of postzygotic reproductive isolation between L. montandoni and L. vulgaris . Despite strong prezygotic isolation, there is evidence for extensive interspecific flow of the mitochondrial DNA (Babik et al 2005; Zieliński et al 2013) as well as for some nuclear gene flow, which is heterogeneous across the genome (Nadachowska-Brzyska et al 2012; Zieliński et al 2014; Stuglik and Babik 2016; Zieliński et al 2016). The linkage map that we report here will facilitate an understanding of the basis of reproductive isolation between these species.…”

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confidence: 99%

Linkage Map ofLissotritonNewts Provides Insight into the Genetic Basis of Reproductive Isolation

Niedzicka

Dudek

Fijarczyk

et al. 2017

G3 Genes|Genomes|Genetics

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Linkage maps are widely used to investigate structure, function, and evolution of genomes. In speciation research, maps facilitate the study of the genetic architecture of reproductive isolation by allowing identification of genomic regions underlying reduced fitness of hybrids. Here we present a linkage map for European newts of the Lissotriton vulgaris species complex, constructed using two families of F2 L. montandoni × L. vulgaris hybrids. The map consists of 1146 protein-coding genes on 12 linkage groups, equal to the haploid chromosome number, with a total length of 1484 cM (1.29 cM per marker). It is notably shorter than two other maps available for salamanders, but the differences in map length are consistent with cytogenetic estimates of the number of chiasmata per chromosomal arm. Thus, large salamander genomes do not necessarily translate into long linkage maps, as previously suggested. Consequently, salamanders are an excellent model to study evolutionary consequences of recombination rate variation in taxa with large genomes and a similar number of chromosomes. A complex pattern of transmission ratio distortion (TRD) was detected: TRD occurred mostly in one family, in one breeding season, and was clustered in two genomic segments. This is consistent with environment-dependent mortality of individuals carrying L. montandoni alleles in these two segments and suggests a role of TRD blocks in reproductive isolation. The reported linkage map will empower studies on the genomic architecture of divergence and interactions between the genomes of hybridizing newts.

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“…The two lineages within L. vulgaris diverged more than 1 Mya (Pabijan et al, 2017;Zieliński et al, 2016), and each of them has experienced a distinct history of hybridization with L. montandoni (Zieliński et al, 2016). In particular, the IN zone appears older .…”

Section: Introductionmentioning

confidence: 99%

Massive introgression of major histocompatibility complex (MHC) genes in newt hybrid zones

et al. 2019

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Variation in the vertebrate major histocompatibility complex (MHC) genes is crucial for fighting pathogen assault. Because new alleles confer a selective advantage, MHC should readily introgress between species, even under limited hybridization. Using replicated transects through two hybrid zones between strongly reproductively isolated European newts, Lissotriton montandoni and L. vulgaris, we demonstrated recent and ongoing MHC class I and II introgression in the Carpathian region. The extent of introgression correlated with the age of contact. In the older zone, MHC similarity between species within transects exceeded similarity between transects within species, implying pervasive introgression ‐ a massive exchange of MHC genes, not limited to specific variants. In simulations, the observed pattern emerged under the combined action of balancing selection and hybridization, but not when these processes acted separately. Thus, massive introgression at advanced stages of divergence can introduce novel and restore previously lost MHC variation, boosting the adaptive potential of hybridizing taxa. In consequence, MHC genes may be the last to stop introgressing between incipient species.

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Divergence history of the Carpathian and smooth newts modelled in space and time

Cited by 23 publications

References 98 publications

Differential introgression across newt hybrid zones: Evidence from replicated transects

Differential introgression across newt hybrid zones: Evidence from replicated transects

Linkage Map ofLissotritonNewts Provides Insight into the Genetic Basis of Reproductive Isolation

Massive introgression of major histocompatibility complex (MHC) genes in newt hybrid zones

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