Divergence of the dengue virus type 2 Cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia, 2008–2014

Kotaki, Tomohiro; Yamanaka, Akira; Mulyatno, Kris Cahyo; Churrotin, Siti; Sucipto, Teguh Hari; Labiqah, Amaliah; Ahwanah, Nur Laila Fitriati; Soegijanto, Soegeng; Kameoka, Masanori; Konishi, Eiji

doi:10.1016/j.meegid.2015.11.002

Cited by 36 publications

(42 citation statements)

References 35 publications

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“…Several shifts in the predominant DENV-4 genotype lineages occurred in the Philippines between 2004-2016. In concurrence with other studies in which genotype and lineage turnover coincide with changes in epidemic activity (19,(35)(36)(37)(38), our study demonstrated an increase in the number of DENV-4 patients during the turnover period. While the GIIa lineage in the Philippines forms a distinct lineage, processes of genotype replacement may have been a result of introductory strains and after that on-going local evolution, with the dominance of lineage L3 from the replacement of lineage L2 and sub-lineages within L3 (L3-1-1b).…”

Section: Discussionsupporting

confidence: 92%

An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines

et al. 2019

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Section: Discussionsupporting

confidence: 92%

An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines

et al. 2019

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“…Using this classification tree, the isolate was grouped together with DENV-2 isolates from other cities in Indonesia (Bali and Palembang). Further analysis of the Cosmopolitan genotype of DENV-2, using sets of sequences from Indonesia from recent years, revealed that the Surabaya 2012 isolate was grouped into the Surabaya lineage of the Cosmopolitan subclade, as proposed by Kotaki, et al [32] (data not shown). The isolate is closely related to an isolate of imported DENV from Indonesia in Taiwan in 2007 [33], and it shares common ancestors with isolates from Bali, Singapore, and Surabaya in 2011.…”

Section: Resultsmentioning

confidence: 72%

“…This genotype is quite commonly found in Southeast Asia, including Indonesia [28]. Further analysis of the Cosmopolitan genotype, using Indonesia DENV isolates from recent years, revealed that the Surabaya 2012 isolate was grouped together into a subclade proposed as the Surabaya lineage, which grouped the majority of isolates from Surabaya during the period of 2008–2014 [32]. The Surabaya 2012 isolate shares common ancestors with the DENV isolate from Taiwan, which was imported from Indonesia.…”

Section: Discussionmentioning

confidence: 99%

Clinical and virological characteristics of dengue in Surabaya, Indonesia

et al. 2017

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Dengue disease is still a major health problem in Indonesia. Surabaya, the second largest city in the country, is endemic for dengue. We report here on dengue disease in Surabaya, investigating the clinical manifestations, the distribution of dengue virus (DENV) serotypes, and the relationships between clinical manifestations and the genetic characteristics of DENV. A total of 148 patients suspected of having dengue were recruited during February-August 2012. One hundred one (68%) of them were children, and 47 (32%) were adults. Dengue fever (DF) and Dengue hemorrhagic fever (DHF) were equally manifested in all of the patients. We performed DENV serotyping on all of the samples using real-time RT-PCR. Of 148, 79 (53%) samples were detected as DENV positive, with DENV-1 as the predominant serotype (73%), followed by DENV-2 (8%), DENV-4 (8%), and DENV-3 (6%), while 5% were mixed infections. Based on the Envelope gene sequences, we performed phylogenetic analyses of 24 isolates to genotype the DENV circulating in Surabaya in 2012, and the analysis revealed that DENV-1 consisted of Genotypes I and IV, DENV-2 was of the Cosmopolitan genotype, the DENV-3 viruses were of Genotype I, and DENV-4 was detected as Genotype II. We correlated the infecting DENV serotypes with clinical manifestations and laboratory parameters; however, no significant correlations were found. Amino acid analysis of Envelope protein did not find any unique mutations related to disease severity.

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“…We also picked up changes in DENV strain circulation, e.g. we isolated a genotype I Asia strain in a traveller returning from Indonesia in 2013 at the same time as local reports describing a shift from the predominantly circulating cosmopolitan genotype strains to Asian genotype strains [33]. …”

Section: Discussionmentioning

confidence: 99%

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

et al. 2017

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We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012–13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014). We were able to characterise dengue viruses imported from regions where currently no virological surveillance data are available. Up to 36% of travellers infected with dengue while travelling returned during the acute phase of the infection (up to 7 days after symptom onset) or became symptomatic after returning to Europe, and 58% of the patients with acute dengue infection were viraemic when seeking medical care. Epidemiological and virological data from dengue-infected international travellers can add an important layer to global surveillance efforts. A considerable number of dengue-infected travellers are viraemic after arrival back home, which poses a risk for dengue introduction and autochthonous transmission in European regions where suitable mosquito vectors are prevalent.

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Divergence of the dengue virus type 2 Cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia, 2008–2014

Cited by 36 publications

References 35 publications

An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines

An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines

Clinical and virological characteristics of dengue in Surabaya, Indonesia

Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative

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