Divergences in Insulin Resistance Between the Different Phenotypes of the Polycystic Ovary Syndrome

Moghetti, Paolo; Tosi, Flavia; Bonin, Cecilia; Sarra, Daniela Di; Fiers, Tom; Kaufman, Jean‐Marc; Giagulli, Vito Angelo; Signori, Chiara; Zambotti, Francesca; Dall'Alda, Marlene; Spiazzi, Giovanna; Zanolin, Maria Elisabetta; Bonora, Enzo

doi:10.1210/jc.2012-3908

Cited by 208 publications

(132 citation statements)

References 68 publications

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“…On the one hand, hyperandrogenemia may predict the metabolic phenotype of these women (16) by increasing the incidence of dysglycemia (16), impaired blood pressure regulation (17), or subclinical atherosclerosis (18), independently of obesity. On the other hand, the classic hyperandrogenic and anovulatory PCOS phenotype that was particularly prevalent in referral patients is associated with insulin resistance and metabolic dysfunction more frequently than with ovulatory phenotypes, even after adjusting by fat mass (19). Furthermore, patients with classic PCOS may show an increased risk for the development of subclinical atherosclerosis compared with patients suffering ovulatory and nonhyperandrogenic PCOS phenotypes (20).…”

Section: Discussionmentioning

confidence: 99%

Referral bias in female functional hyperandrogenism and polycystic ovary syndrome

Luque‐Ramírez

Alpañés

Sanchón

et al. 2015

European Journal of Endocrinology

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Objective: Women with polycystic ovary syndrome (PCOS) seeking health care in the United States may be more obese and hyperandrogenic than those present in the general population. We aimed to assess the impact of referral bias on European women with functional androgen excess disorders. Design: Cross-sectional study. Methods: We studied two groups of patients: i) 368 consecutive patients referred to our clinic for the study of functional hyperandrogenism (FH) (referral patients); ii) 57 consecutive premenopausal patients identified by screening during blood donation (unselected patients). We compared the anthropometric data from the groups of patients with those of two control populations: iii) a group of unselected premenopausal healthy female blood donors (unselected controls); and iv) data available from the local general premenopausal female population. Results: Referral patients with FH were more hirsute, had a higher percentage of hyperandrogenemia, and fulfilled PCOS criteria more frequently than unselected patients. The prevalence of obesity in unselected controls was similar to that observed in the general population, whereas referral patients and unselected patients were more frequently obese. The prevalence of obesity was also higher among referral patients compared to unselected patients. Conclusion: Referral bias influences the phenotype of patients with FH. Patients studied at the clinical setting may show more severe hyperandrogenic and obese phenotypes than patients from the general population, even though PCOS appears to be associated with weight excess also in the general European population. This fact should be considered when establishing reference values and control populations for clinical and research purposes.

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Section: Discussionmentioning

confidence: 99%

Referral bias in female functional hyperandrogenism and polycystic ovary syndrome

Luque‐Ramírez

Alpañés

Sanchón

et al. 2015

European Journal of Endocrinology

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“…During the past years, it has become evident that alterations in insulin action are frequent in women with PCOS (18)(19)(20)(21)(22)(23)(24). About 60%-70% of PCOS patients present central obesity that is well known to be associated with insulin resistance and increased risk of type 2 diabetes mellitus, hypertension, dyslipidemia, endothelial dysfunction and heart disease (25).…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid Concentration in Overweight and Obese Women with Polycystic Ovary Syndrome / Nivelul acidului uric la femeile supraponderale și obeze cu sindromul ovarelor polichistice

Leuștean¹,

Dimitriu²,

Fica³

et al. 2015

Romanian Review of Laboratory Medicine

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“…The Rotterdam criteria also recognize a fourth phenotype, Mild 8 or Normoandrogenic PCOS, 9 which is defined by oligomenorrhea, PCO, and normal androgens. Whether these 4 phenotypes represent a spectrum of the same condition is currently an area of debate.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology: An Assessment of Over 100 Consecutive Women Self-reporting Features of Polycystic Ovary Syndrome

et al. 2014

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The prevalence of polycystic ovary syndrome (PCOS) and its distinct clinical phenotypes were assessed using 3 sets of international diagnostic criteria in women self-reporting concerns over outward features of PCOS. Revised ultrasonographic criteria for polycystic ovaries (PCO) based on modern ultrasound technology were used. Of the participants, 53%, 62%, and 70% were diagnosed with PCOS using National Institutes of Health, Androgen Excess and PCOS Society, and Rotterdam criteria, respectively. Prevalence of Frank, Ovulatory, Normoandrogenic, and Non-PCO PCOS were 66%, 13%, 11%, and 9%, respectively. Frank PCOS was associated with the severest metabolic disturbances whereas metabolic profiles in Normoandrogenic PCOS did not differ from controls, supporting reduced health risks in women without androgen excess. Metabolic disturbances and hyperandrogenism were linked to excess adiposity across all the groups. Using updated criteria for PCO, the prevalence of Non-PCO PCOS and PCO alone in healthy women recruited from the general population was reduced compared to the previous reports.

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Divergences in Insulin Resistance Between the Different Phenotypes of the Polycystic Ovary Syndrome

Cited by 208 publications

References 68 publications

Referral bias in female functional hyperandrogenism and polycystic ovary syndrome

Referral bias in female functional hyperandrogenism and polycystic ovary syndrome

Serum Uric Acid Concentration in Overweight and Obese Women with Polycystic Ovary Syndrome / Nivelul acidului uric la femeile supraponderale și obeze cu sindromul ovarelor polichistice

Prevalence of Polycystic Ovary Syndrome Phenotypes Using Updated Criteria for Polycystic Ovarian Morphology: An Assessment of Over 100 Consecutive Women Self-reporting Features of Polycystic Ovary Syndrome

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