Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection

Sena, Angela A.; Glavan, Tiffany; Jiang, Guochun; Sankaran-Walters, Sumathi; Grishina, Irina; Dandekar, Satya; Goulart, Luiz Ricardo

doi:10.1038/srep31157

Cited by 11 publications

(7 citation statements)

References 72 publications

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“…DCs in the maturational stage were immune-suppressive ( Table 3 ). DCs expressed PD-L1 , Jchain , and Anxa1 , which were correlated with immune tolerance and refrained the secretion of pro-inflammatory cytokines ( Källberg and Leanderson, 2008 ; Sena et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage

Zhang

Long

et al. 2022

Front. Genet.

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Endometrium undergoes repeated repair and regeneration during the menstrual cycle. Previous attempts using gene expression data to define the menstrual cycle failed to come to an agreement. Here we used single-cell RNA sequencing data of C57BL/6J mice uteri to construct a novel integrated cell atlas of mice uteri from the regenerative endometrium to the maturational endometrium at the single-cell level, providing a more accurate cytological-based elucidation for the changes that occurred in the endometrium during the estrus cycle. Based on the expression levels of proliferating cell nuclear antigen, differentially expressed genes, and gene ontology terms, we delineated in detail the transitions of epithelial cells, stromal cells, and immune cells that happened during the estrus cycle. The transcription factors that shaped the differentiation of the mononuclear phagocyte system had been proposed, being Mafb, Irf7, and Nr4a1. The amounts and functions of immune cells varied sharply in two stages, especially NK cells and macrophages. We also found putative uterus tissue-resident macrophages and identified potential endometrial mesenchymal stem cells (high expression of Cd34, Pdgfrb, Aldh1a2) in vivo. The cell atlas of mice uteri presented here would improve our understanding of the transitions that occurred in the endometrium from the regenerative endometrium to the maturational endometrium. With the assistance of a normal cell atlas as a reference, we may identify morphologically unaffected abnormalities in future clinical practice. Cautions would be needed when adopting our conclusions, for the limited number of mice that participated in this study may affect the strength of our conclusions.

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Section: Resultsmentioning

confidence: 99%

Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage

Zhang

Long

et al. 2022

Front. Genet.

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“…MS), Th17 cells exhibited a significant reduction in ANXA1 production, also reflecting how downregulation of this protein is associated with increased inflammation [ 86] . Th17 responses have also been shown to negatively correlate with ANXA1 expression in other models of inflammation, including in studies in primates with simian immunodeficiency virus (SIV) infection [ 87] .…”

Section: Anxa1 In Diseasementioning

confidence: 99%

Annexin‐A1: The culprit or the solution?

et al. 2022

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Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has been implicated in a range of inflammatory conditions and cancers, as well as being found to be overexpressed on the T cells of patients with autoimmune disease. Moreover, the formyl peptide family of receptors, through which annexin‐A1 primarily signals, has also been implicated in these diseases. In contrast, treatment with recombinant annexin‐A1 peptides resulted in suppression of inflammatory processes in murine models of inflammation. This review will focus on what is currently known about annexin‐A1 in health and disease and discuss the potential of this protein as a biomarker and therapeutic target.

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“…DCs in the maturational phase were immune-suppressive ( Figure 4J). DCs expressed PD-L1, Jchain, and Anxa1, which were correlated with immune tolerance and refrained the secretions of pro-in ammatory cytokines [38,39].…”

Section: The Immune Landscape Of Uterus During the Estrus Cyclementioning

confidence: 99%

Digital Cell Atlas of Mouse Uterus: From Regenerative Phase to Maturational Phase

Zhang

2020

Preprint

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Background: Endometria undergo repeated repair and regeneration during the menstrual cycle. Using gene expression to define the menstrual cycle has been seen in a couple of researches, which shares little consistency. The possible reason lies in the fact that the composition of each specimen is different. The objective of this study was to reconstruct an integrated cell atlas of mouse uterus from the regenerative to maturational endometrium at the single-cell level.Methods: We used published single-cell RNA sequencing data of mice uteri to build an integrated cell atlas, including epithelial cells, stromal cells, and immune cells. Principal components analysis, hierarchical clustering, and other data mining procedures were performed with R software. Functional enrichment analyses were performed to identify the potential biological roles of molecular changes in different mice estrus states.Results: Based on the expression level of proliferating cell nuclear antigen and gene ontology terms, we reconstructed the cell atlas and delineated in detail the transitions that happened during the estrus cycle. We also depicted the transition and transcription factors that shaped the differentiation of ESCs and the mononuclear phagocyte system. Besides, the amounts and functions of immune cells varied sharply in two periods. We also found clues about uterus tissue-resident macrophages and Pdgfrb+ Aldh1a2+ Cd34+ endometrial mesenchymal stem cells in vivo.Conclusions: The cell atlas of mouse uterus presented here would improve our understanding of the functional changes that occurred in the endometrium and helped us identify abnormalities that have not been apparent histologically.

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Divergent Annexin A1 expression in periphery and gut is associated with systemic immune activation and impaired gut immune response during SIV infection

Cited by 11 publications

References 72 publications

Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage

Digital Cell Atlas of Mouse Uterus: From Regenerative Stage to Maturational Stage

Annexin‐A1: The culprit or the solution?

Digital Cell Atlas of Mouse Uterus: From Regenerative Phase to Maturational Phase

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